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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:erythropoietin signaling pathway
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Accession:PW:0000987 term browser browse the term
Definition:Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade.
Synonyms:exact_synonym: EPO signaling pathway
 related_synonym: PID:200183


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erythropoietin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator ISO PID PID:200183 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BCL2L1 BCL2 like 1 ISO PID PID:200183 NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585 		JBrowse link
G BTK Bruton tyrosine kinase ISO PID PID:200183 NCBI chr  X:90,551,874...90,588,786
Ensembl chr  X:100,684,017...100,725,187 		JBrowse link
G CBL Cbl proto-oncogene ISO PID PID:200183 NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671 		JBrowse link
G CRKL CRK like proto-oncogene, adaptor protein ISO PID PID:200183 NCBI chr22:3,141,147...3,177,448
Ensembl chr22:19,632,359...19,668,858 		JBrowse link
G EPO erythropoietin ISO PID PID:200183 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974 		JBrowse link
G EPOR erythropoietin receptor ISO PID PID:200183 NCBI chr19:10,925,148...10,931,955
Ensembl chr19:11,635,248...11,642,383 		JBrowse link
G GAB1 GRB2 associated binding protein 1 ISO PID PID:200183 NCBI chr 4:135,697,939...135,834,755
Ensembl chr 4:146,996,936...147,133,672 		JBrowse link
G GRB2 growth factor receptor bound protein 2 ISO PID PID:200183 NCBI chr17:69,265,307...69,352,835
Ensembl chr17:74,817,471...74,903,796 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO PID PID:200183 NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D ISO PID PID:200183 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G IRS2 insulin receptor substrate 2 ISO PID PID:200183 NCBI chr13:90,886,095...90,917,724 JBrowse link
G JAK2 Janus kinase 2 ISO PID PID:200183 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A ISO PID PID:200183 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOC100989105 signal transducer and activator of transcription 5B ISO PID PID:200183 NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200183 NCBI chr 8:52,318,497...52,455,741
Ensembl chr 8:49,755,708...49,825,287 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 ISO PID PID:200183 NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO PID PID:200183 NCBI chr10:45,806,748...45,936,362 JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO PID PID:200183 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200183 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G PLCG1 phospholipase C gamma 1 ISO PID PID:200183 NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145 		JBrowse link
G PLCG2 phospholipase C gamma 2 ISO PID PID:200183 NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO PID PID:200183 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO PID PID:200183 NCBI chr12:7,075,879...7,093,041
Ensembl chr12:6,991,099...7,008,830 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family ISO PID PID:200183 NCBI chr 1:114,279,255...114,376,977
Ensembl chr 1:125,971,598...125,994,813 		JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 ISO PID PID:200183 NCBI chr 9:102,698,970...102,861,482
Ensembl chr 9:131,337,001...131,495,664 		JBrowse link
G SH2B3 SH2B adaptor protein 3 ISO PID PID:200183 NCBI chr12:108,977,344...109,024,029 JBrowse link
G SHC1 SHC adaptor protein 1 ISO PID PID:200183 NCBI chr 1:130,310,778...130,323,001
Ensembl chr 1:133,920,532...133,929,008 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO PID PID:200183 NCBI chr17:72,433,206...72,436,500
Ensembl chr17:77,983,389...77,984,066 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200183 NCBI chr2A:39,019,046...39,162,248
Ensembl chr2A:39,773,760...39,911,961 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO PID PID:200183 NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280 		JBrowse link
G TEC tec protein tyrosine kinase ISO PID PID:200183 NCBI chr 4:73,885,588...74,018,061
Ensembl chr 4:84,618,088...84,750,319 		JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 ISO PID PID:200183 NCBI chr11:96,414,498...96,551,670
Ensembl chr11:99,919,410...100,050,685 		JBrowse link
G VAV2 vav guanine nucleotide exchange factor 2 ISO PID PID:200183 NCBI chr 9:104,883,197...105,115,143
Ensembl chr 9:133,494,481...133,668,036 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    signaling pathway 1930
      hormone signaling pathway 380
        peptide and protein hormone signaling pathway 273
          erythropoietin signaling pathway 34
paths to the root