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ONTOLOGY REPORT - ANNOTATIONS

Term:calcitriol biosynthetic process from calciol
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Accession:GO:0036378 term browser browse the term
Definition:Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
Synonyms:exact_synonym: calcitriol biosynthesis from calciol;   vitamin D3 activation
 broad_synonym: 1alpha,25(OH)2D3 biosynthesis;   1alpha,25-dihydroxycholecalciferol biosynthesis;   1alpha,25-dihydroxyvitamin D3 biosynthesis


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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr37:25,366,475...25,401,978
Ensembl chr37:25,366,472...25,401,509 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 involved_in ISO (PMID:15465040), (PMID:18511070) UniProt PMID:15465040 PMID:18511070 NCBI chr21:37,553,883...37,579,744
Ensembl chr21:37,552,732...37,606,725 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17919
    metabolic process 11001
      small molecule metabolic process 1831
        alcohol metabolic process 357
          secondary alcohol metabolic process 154
            vitamin D3 metabolic process 6
              calcitriol biosynthetic process from calciol 3
Path 2
Term Annotations click to browse term
  biological_process 17919
    metabolic process 11001
      primary metabolic process 9575
        lipid metabolic process 1367
          steroid metabolic process 321
            steroid biosynthetic process 172
              vitamin D biosynthetic process 7
                calcitriol biosynthetic process from calciol 3
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