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ONTOLOGY REPORT - ANNOTATIONS

Term:vitamin D biosynthetic process
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Accession:GO:0042368 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
Synonyms:exact_synonym: vitamin D anabolism;   vitamin D biosynthesis;   vitamin D formation;   vitamin D synthesis
 narrow_synonym: calciferol biosynthesis;   calciferol biosynthetic process;   cholecalciferol biosynthesis;   cholecalciferol biosynthetic process;   ergocalciferol biosynthesis;   ergocalciferol biosynthetic process


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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
(PMID:15465040)		 Ensembl
RGD		 PMID:15465040 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in ISO
IEA
IBA		 (PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
GO_REF:0000107
(MGI:3590419|PMID:15972816)
PMID:21873635		 RGD
Ensembl		 PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 PMID:17023519 More... GO_REF:0000107 MGI:3590419, RGD:13792537 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:15465040), (PMID:18511070)
(MGI:2677973|PMID:12867411)		 RGD PMID:12867411 PMID:15465040 PMID:18511070 MGI:2677973 NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in ISO
IEA		 (PMID:16549446)
GO_REF:0000107		 RGD
Ensembl		 PMID:16549446 GO_REF:0000107 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor involved_in ISO (PMID:15947108) RGD PMID:15947108 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) RGD PMID:15243130 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:19502595) RGD PMID:19502595 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:18485278), (PMID:19502595) RGD PMID:18485278 PMID:19502595 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
positive regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:9282826) RGD PMID:9282826 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:1690216) RGD PMID:1690216 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19896
    metabolic process 12209
      organic substance metabolic process 11750
        organic substance biosynthetic process 6193
          organic hydroxy compound biosynthetic process 254
            vitamin D biosynthetic process 10
              calcitriol biosynthetic process from calciol 4
              negative regulation of vitamin D biosynthetic process + 5
              positive regulation of vitamin D biosynthetic process 2
              regulation of vitamin D biosynthetic process + 7
              vitamin D3 biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 19896
    metabolic process 12209
      primary metabolic process 10965
        lipid metabolic process 1456
          steroid metabolic process 352
            steroid biosynthetic process 179
              vitamin D biosynthetic process 10
                calcitriol biosynthetic process from calciol 4
                negative regulation of vitamin D biosynthetic process + 5
                positive regulation of vitamin D biosynthetic process 2
                regulation of vitamin D biosynthetic process + 7
                vitamin D3 biosynthetic process 0
paths to the root