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ONTOLOGY REPORT - ANNOTATIONS


Term:ammonia assimilation cycle
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Accession:GO:0019676 term browser browse the term
Definition:The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
Synonyms:exact_synonym: glutamate metabolic process via glutamine and ammonia;   glutamate metabolism via glutamine and ammonia
 xref: MetaCyc:AMMASSIM-PWY;   MetaCyc:PWY-3282



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ammonia assimilation cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asl argininosuccinate lyase acts_upstream_of_or_within ISO MGI:3604881 (MGI:3604426|PMID:12559843) RGD PMID:12559843 MGI:3604426 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Glul glutamate-ammonia ligase TAS
IDA
RGD PMID:1674354 PMID:28323 RGD:632694, RGD:2301547 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
positive regulation of ammonia assimilation cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA
(MGI:5306122|PMID:21757002)
GO_REF:0000107
RGD
Ensembl
PMID:21757002 GO_REF:0000107 MGI:5306122 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    response to stimulus 10542
      response to external stimulus 3276
        response to extracellular stimulus 814
          response to nutrient levels 783
            nitrogen utilization 6
              ammonia assimilation cycle 3
                negative regulation of ammonia assimilation cycle 0
                positive regulation of ammonia assimilation cycle 1
                regulation of ammonia assimilation cycle + 1
Path 2
Term Annotations click to browse term
  biological_process 20099
    cellular process 18695
      cellular metabolic process 10470
        organic acid metabolic process 1058
          oxoacid metabolic process 1044
            carboxylic acid metabolic process 1030
              cellular amino acid metabolic process 310
                alpha-amino acid metabolic process 227
                  glutamine family amino acid metabolic process 83
                    glutamine metabolic process 23
                      ammonia assimilation cycle 3
                        negative regulation of ammonia assimilation cycle 0
                        positive regulation of ammonia assimilation cycle 1
                        regulation of ammonia assimilation cycle + 1
paths to the root