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ONTOLOGY REPORT - ANNOTATIONS

Term:nitric oxide mediated signal transduction
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Accession:GO:0007263 term browser browse the term
Definition:An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
Synonyms:exact_synonym: NO mediated signal transduction;   nitric oxide signaling

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nitric oxide mediated signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase involved_in ISO PMID:19607794 UniProt PMID:19607794 RGD:8553565 NCBI chrNW_004936709:1,243,149...1,247,782
Ensembl chrNW_004936709:1,243,147...1,247,903 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16614755) Ensembl
MGI		 PMID:16614755 GO_REF:0000107 NCBI chrNW_004936576:2,353,874...2,411,747
Ensembl chrNW_004936576:2,353,761...2,411,425 		JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16614755) Ensembl
MGI		 PMID:16614755 GO_REF:0000107 NCBI chrNW_004936551:1,573,930...1,814,685
Ensembl chrNW_004936551:1,575,356...1,814,697 		JBrowse link
G Ndnf neuron derived neurotrophic factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:593,848...624,974
Ensembl chrNW_004936662:594,331...624,980 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO nitric oxide stimulation of GnRH release RGD PMID:11711887 RGD:1642593 NCBI chrNW_004936576:1,932,526...1,939,560
Ensembl chrNW_004936576:1,932,870...1,938,703 		JBrowse link
G Rasd1 ras related dexamethasone induced 1 ISO RGD PMID:11086993 RGD:633891 NCBI chrNW_004936741:1,120,527...1,123,326
Ensembl chrNW_004936741:1,121,303...1,123,386 		JBrowse link
G Rilpl1 Rab interacting lysosomal protein like 1 involved_in ISO PMID:19607794 UniProt PMID:19607794 RGD:8553565 NCBI chrNW_004936558:1,261,103...1,294,397
Ensembl chrNW_004936558:1,261,103...1,296,606 		JBrowse link
G Spink1 serine peptidase inhibitor Kazal type 1 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:22228629) Ensembl
MGI		 PMID:22228629 GO_REF:0000107 NCBI chrNW_004936504:6,975,044...6,981,304
Ensembl chrNW_004936504:6,975,044...6,981,304 		JBrowse link
negative regulation of nitric oxide mediated signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spink1 serine peptidase inhibitor Kazal type 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22228629) Ensembl
MGI		 PMID:22228629 GO_REF:0000107 NCBI chrNW_004936504:6,975,044...6,981,304
Ensembl chrNW_004936504:6,975,044...6,981,304 		JBrowse link
G Thbs1 thrombospondin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16150726) MGI
Ensembl		 PMID:16150726 GO_REF:0000107 NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949 		JBrowse link
nitric oxide-cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:8995232) BHF-UCL PMID:8995232 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in
acts_upstream_of_negative_effect		 IEA
ISO		 (PMID:19278978) Ensembl
BHF-UCL		 PMID:19278978 GO_REF:0000107 NCBI chrNW_004936567:944,825...1,039,920
Ensembl chrNW_004936567:950,797...993,245 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936576:2,353,874...2,411,747
Ensembl chrNW_004936576:2,353,761...2,411,425 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936576:2,427,451...2,469,946
Ensembl chrNW_004936576:2,427,416...2,470,072 		JBrowse link
G Ins insulin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936816:1,002,137...1,003,357
Ensembl chrNW_004936816:1,002,137...1,003,357 		JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 involved_in ISO PMID:11281123 UniProt PMID:11281123 RGD:10047322 NCBI chrNW_004936568:3,508,212...3,694,459
Ensembl chrNW_004936568:3,511,244...3,694,781 		JBrowse link
G Nos1 nitric oxide synthase 1 involved_in ISO PMID:19278978 BHF-UCL PMID:19278978 RGD:10047220 NCBI chrNW_004936558:5,162,471...5,302,488
Ensembl chrNW_004936558:5,233,459...5,301,414 		JBrowse link
G Thbs1 thrombospondin 1 involved_in
acts_upstream_of_negative_effect		 IEA
ISO		 (PMID:17416590) Ensembl
BHF-UCL		 PMID:17416590 GO_REF:0000107 NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949 		JBrowse link
positive regulation of nitric oxide mediated signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16614755) Ensembl
MGI		 PMID:16614755 GO_REF:0000107 NCBI chrNW_004936576:2,353,874...2,411,747
Ensembl chrNW_004936576:2,353,761...2,411,425 		JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16614755) Ensembl
MGI		 PMID:16614755 GO_REF:0000107 NCBI chrNW_004936551:1,573,930...1,814,685
Ensembl chrNW_004936551:1,575,356...1,814,697 		JBrowse link
G Ins insulin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936816:1,002,137...1,003,357
Ensembl chrNW_004936816:1,002,137...1,003,357 		JBrowse link
regulation of nitric oxide mediated signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta-synthase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10953023) Ensembl
MGI		 PMID:10953023 GO_REF:0000107 NCBI chrNW_004936500:976,043...1,003,559
Ensembl chrNW_004936500:987,128...1,003,388 		JBrowse link
G Pde2a phosphodiesterase 2A acts_upstream_of_or_within ISO (PMID:16150726) MGI PMID:16150726 NCBI chrNW_004936498:1,856,256...1,944,405
Ensembl chrNW_004936498:1,856,144...1,944,412 		JBrowse link
G Pde5a phosphodiesterase 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16150726) Ensembl
MGI		 PMID:16150726 GO_REF:0000107 NCBI chrNW_004936869:24,265...117,120
Ensembl chrNW_004936869:39,122...117,127 		JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16150726) MGI
Ensembl		 PMID:16150726 GO_REF:0000107 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15975
    cellular process 15075
      signal transduction 5706
        intracellular signal transduction 2556
          intracellular signaling cassette 1777
            nitric oxide mediated signal transduction 21
              negative regulation of nitric oxide mediated signal transduction + 2
              nitric oxide-cGMP-mediated signaling + 10
              positive regulation of nitric oxide mediated signal transduction + 3
              regulation of nitric oxide mediated signal transduction + 9
Path 2
Term Annotations click to browse term
  biological_process 15975
    biological regulation 11165
      regulation of biological process 10825
        signaling 6194
          signal transduction 5706
            intracellular signal transduction 2556
              intracellular signaling cassette 1777
                nitric oxide mediated signal transduction 21
                  negative regulation of nitric oxide mediated signal transduction + 2
                  nitric oxide-cGMP-mediated signaling + 10
                  positive regulation of nitric oxide mediated signal transduction + 3
                  regulation of nitric oxide mediated signal transduction + 9
paths to the root