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ONTOLOGY REPORT - ANNOTATIONS


Term:glucocorticoid biosynthetic process
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Accession:GO:0006704 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: glucocorticoid anabolism;   glucocorticoid biosynthesis;   glucocorticoid formation;   glucocorticoid synthesis


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glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1860037|PMID:10861000) MGI
Ensembl
PMID:10861000 GO_REF:0000107 MGI:1860037 NCBI chrNW_004936496:7,759,656...7,761,555
Ensembl chrNW_004936496:7,760,532...7,761,122
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chrNW_004936557:3,358,809...3,403,461
Ensembl chrNW_004936557:3,357,016...3,403,714
JBrowse link
G LOC101957714 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936514:1,467,460...1,480,185
Ensembl chrNW_004936514:1,467,261...1,480,185
JBrowse link
G LOC101963150 sterol 26-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936569:1,213,700...1,250,181
Ensembl chrNW_004936569:1,213,573...1,250,589
JBrowse link
G LOC101968373 cytochrome P450 11B3, mitochondrial-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:9,034,177...9,039,486 JBrowse link
G LOC101970767 steroid 17-alpha-hydroxylase/17,20 lyase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:77279|PMID:7588219) MGI
Ensembl
PMID:7588219 GO_REF:0000107 MGI:77279 NCBI chrNW_004936600:3,097,620...3,102,713
Ensembl chrNW_004936600:3,097,638...3,102,713
JBrowse link
G LOC101975820 cholesterol side-chain cleavage enzyme, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:33,367,810...33,380,764
Ensembl chrNW_004936471:33,367,810...33,380,764
JBrowse link
G LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936646:1,899,686...1,904,104
Ensembl chrNW_004936646:1,900,259...1,904,104
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO PMID:19342457
(PMID:19342457)
UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:12,428,765...12,439,570
Ensembl chrNW_004936485:12,428,710...12,439,454
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:5,350,870...5,464,561
Ensembl chrNW_004936476:5,350,870...5,464,354
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:6,428,824...6,477,007
Ensembl chrNW_004936528:6,429,973...6,477,218
JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004936482:19,018,454...19,040,438 JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3696486|PMID:17234593) MGI
Ensembl
PMID:17234593 GO_REF:0000107 MGI:3696486 NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:7,623,462...7,635,416
Ensembl chrNW_004936474:7,623,463...7,635,664
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:22,225,624...22,238,825
Ensembl chrNW_004936477:22,225,618...22,238,803
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936623:3,359,624...3,376,598
Ensembl chrNW_004936623:3,351,716...3,375,146
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3 group C member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:74913|PMID:7628695) MGI
Ensembl
PMID:7628695 GO_REF:0000107 MGI:74913 NCBI chrNW_004936504:10,960,069...11,056,834
Ensembl chrNW_004936504:10,959,192...11,056,856
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15863
    metabolic process 9515
      organic substance metabolic process 9078
        organic cyclic compound metabolic process 5101
          steroid metabolic process 295
            glucocorticoid metabolic process 27
              glucocorticoid biosynthetic process 18
                cortisol biosynthetic process + 8
                negative regulation of glucocorticoid biosynthetic process + 5
                positive regulation of glucocorticoid biosynthetic process + 1
                regulation of glucocorticoid biosynthetic process + 9
Path 2
Term Annotations click to browse term
  biological_process 15863
    metabolic process 9515
      primary metabolic process 8307
        lipid metabolic process 1278
          lipid biosynthetic process 642
            steroid biosynthetic process 154
              steroid hormone biosynthetic process 37
                glucocorticoid biosynthetic process 18
                  cortisol biosynthetic process + 8
                  negative regulation of glucocorticoid biosynthetic process + 5
                  positive regulation of glucocorticoid biosynthetic process + 1
                  regulation of glucocorticoid biosynthetic process + 9
paths to the root