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ONTOLOGY REPORT - ANNOTATIONS

Term:glucocorticoid biosynthetic process
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Accession:GO:0006704 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: glucocorticoid anabolism;   glucocorticoid biosynthesis;   glucocorticoid formation;   glucocorticoid synthesis

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glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10861000) Ensembl
MGI		 PMID:10861000 GO_REF:0000107 NCBI chrNW_004936496:7,759,656...7,761,555
Ensembl chrNW_004936496:7,760,532...7,761,122 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chrNW_004936557:3,358,809...3,403,461
Ensembl chrNW_004936557:3,357,016...3,403,714 		JBrowse link
G LOC101957714 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936514:1,467,460...1,480,185
Ensembl chrNW_004936514:1,467,261...1,480,185 		JBrowse link
G LOC101968373 cytochrome P450 11B3, mitochondrial-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:9,034,177...9,039,486 JBrowse link
G LOC101970767 steroid 17-alpha-hydroxylase/17,20 lyase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7588219) Ensembl
MGI		 PMID:7588219 GO_REF:0000107 NCBI chrNW_004936600:3,097,620...3,102,713
Ensembl chrNW_004936600:3,097,638...3,102,713 		JBrowse link
G LOC101975820 cholesterol side-chain cleavage enzyme, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:33,367,810...33,380,764
Ensembl chrNW_004936471:33,367,810...33,380,764 		JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO PMID:19342457
(PMID:19342457)		 UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:12,428,765...12,439,570
Ensembl chrNW_004936485:12,428,710...12,439,454 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:5,350,870...5,464,561
Ensembl chrNW_004936476:5,350,870...5,464,354 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:6,428,824...6,477,007
Ensembl chrNW_004936528:6,429,973...6,477,218 		JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004936482:19,018,454...19,040,438 JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17234593) Ensembl
MGI		 PMID:17234593 GO_REF:0000107 NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638 		JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:7,623,462...7,635,416
Ensembl chrNW_004936474:7,623,463...7,635,664 		JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:22,225,624...22,238,825
Ensembl chrNW_004936477:22,225,618...22,238,803 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936623:3,359,624...3,376,598
Ensembl chrNW_004936623:3,351,716...3,375,146 		JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3 group C member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7628695) Ensembl
MGI		 PMID:7628695 GO_REF:0000107 NCBI chrNW_004936504:10,960,069...11,056,834
Ensembl chrNW_004936504:10,959,192...11,056,856 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15910
    metabolic process 9595
      primary metabolic process 8373
        lipid metabolic process 1256
          steroid metabolic process 291
            glucocorticoid metabolic process 25
              glucocorticoid biosynthetic process 16
                cortisol biosynthetic process + 8
                negative regulation of glucocorticoid biosynthetic process + 5
                positive regulation of glucocorticoid biosynthetic process + 1
                regulation of glucocorticoid biosynthetic process + 9
Path 2
Term Annotations click to browse term
  biological_process 15910
    metabolic process 9595
      primary metabolic process 8373
        lipid metabolic process 1256
          steroid metabolic process 291
            steroid biosynthetic process 153
              steroid hormone biosynthetic process 35
                glucocorticoid biosynthetic process 16
                  cortisol biosynthetic process + 8
                  negative regulation of glucocorticoid biosynthetic process + 5
                  positive regulation of glucocorticoid biosynthetic process + 1
                  regulation of glucocorticoid biosynthetic process + 9
paths to the root