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ONTOLOGY REPORT - ANNOTATIONS


Term:glucocorticoid metabolic process
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Accession:GO:0008211 term browser browse the term
Definition:The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
Synonyms:exact_synonym: glucocorticoid metabolism;   glucocorticosteroid metabolic process;   glucocorticosteroid metabolism


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glucocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 acts_upstream_of_or_within ISO MGI:2180783 (MGI:2180727|PMID:8647961) RGD PMID:8647961 MGI:2180727 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 TAS RGD PMID:11796518 RGD:70385 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 IDA RGD PMID:16763064 PMID:11755176 RGD:1625084, RGD:727334 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Mecp2 methyl CpG binding protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2183727 (MGI:3695672|PMID:17108082)
Ensembl
RGD
PMID:17108082 GO_REF:0000107 MGI:3695672 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 acts_upstream_of_or_within ISO MGI:1857745 (MGI:1344888|PMID:10509797) RGD PMID:10509797 MGI:1344888 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Serpina6 serpin family A member 6 acts_upstream_of_or_within ISO MGI:3664470 (MGI:3664152|PMID:16980625) RGD PMID:16980625 MGI:3664152 NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349
JBrowse link
G Star steroidogenic acute regulatory protein acts_upstream_of_or_within ISO MGI:2388706 (MGI:1098076|PMID:9326645) RGD PMID:9326645 MGI:1098076 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IMP
IEA
ISO
PMID:19342457
GO_REF:0000107
(PMID:19342457)
Ensembl
RGD
PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IMP PMID:19342457 UniProt PMID:19342457 RGD:4891166 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 NOT|involved_in ISO (PMID:9703385)
(PMID:19342457)
RGD PMID:9703385 PMID:19342457 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
cortisol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone acts_upstream_of_or_within ISO MGI:1857392 (MGI:1860037|PMID:10861000) RGD PMID:10861000 MGI:1860037 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IDA
IBA
corticosterone
PMID:21873635
RGD
GO_Central
PMID:19665544 PMID:21873635 RGD:4891164, RGD:13792537 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IDA
IBA
corticosterone, 18-hydroxycorticosterone
PMID:21873635
RGD
GO_Central
PMID:11832364 PMID:21873635 RGD:727991, RGD:13792537 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 acts_upstream_of_or_within ISO (MGI:1336546|PMID:10224232), (MGI:50073|PMID:1686470), (MGI:80407|PMID:8645611) RGD PMID:1686470 PMID:8645611 PMID:10224232 MGI:1336546 MGI:50073 MGI:80407 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:77279|PMID:7588219)
GO_REF:0000041
Ensembl
RGD
UniProt
PMID:7588219 GO_REF:0000041 GO_REF:0000107 MGI:77279 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:12460758 RGD:1625060 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
glucocorticoid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:12460758 RGD:1625060 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta involved_in ISO
IEA
(PMID:15790729)
GO_REF:0000107
RGD
Ensembl
PMID:15790729 GO_REF:0000107 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO
IEA
(PMID:19584291)
GO_REF:0000107
RGD
Ensembl
PMID:19584291 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IEA
IMP
(PMID:19342457)
GO_REF:0000107
RGD
Ensembl
PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within ISO MGI:2451290 (MGI:3696486|PMID:17234593) RGD PMID:17234593 MGI:3696486 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16981135)
Ensembl
RGD
PMID:16981135 GO_REF:0000107 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:24369117) RGD PMID:24369117 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in ISO (PMID:18628520), (PMID:23132696)
(MGI:3623644|PMID:16356929)
RGD PMID:16356929 PMID:18628520 PMID:23132696 MGI:3623644 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 acts_upstream_of_or_within ISO MGI:1857745 (MGI:74913|PMID:7628695) RGD PMID:7628695 MGI:74913 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
regulation of glucocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gal galanin and GMAP prepropeptide IMP RGD PMID:17273801 RGD:1624340 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (PMID:11146632) RGD PMID:11146632 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      primary metabolic process 10531
        lipid metabolic process 1364
          steroid metabolic process 334
            glucocorticoid metabolic process 26
              cortisol metabolic process + 12
              glucocorticoid biosynthetic process + 18
              glucocorticoid catabolic process + 2
              negative regulation of glucocorticoid metabolic process + 5
              positive regulation of glucocorticoid metabolic process + 1
              regulation of glucocorticoid metabolic process + 11
paths to the root