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ONTOLOGY REPORT - ANNOTATIONS


Term:glucocorticoid metabolic process
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Accession:GO:0008211 term browser browse the term
Definition:The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
Synonyms:exact_synonym: glucocorticoid metabolism;   glucocorticosteroid metabolic process;   glucocorticosteroid metabolism


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glucocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 ISO MGI:MGI:2180783 (MGI:MGI:2180727|PMID:8647961) RGD PMID:8647961 MGI:MGI:2180727 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 TAS RGD PMID:11796518 RGD:70385
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 IDA RGD PMID:16763064 RGD:1625084 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO
IEA
MGI:MGI:2183727 (MGI:MGI:3695672|PMID:17108082)
GO_REF:0000107
RGD
Ensembl
PMID:17108082 GO_REF:0000107, MGI:MGI:3695672 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO MGI:MGI:1857745 (MGI:MGI:1344888|PMID:10509797) RGD PMID:10509797 MGI:MGI:1344888 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Serpina6 serpin family A member 6 ISO MGI:MGI:3664470 (MGI:MGI:3664152|PMID:16980625) RGD PMID:16980625 MGI:MGI:3664152 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
JBrowse link
G Star steroidogenic acute regulatory protein ISO MGI:MGI:2388706 (MGI:MGI:1098076|PMID:9326645) RGD PMID:9326645 MGI:MGI:1098076 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H IMP
IEA
ISO
PMID:19342457
GO_REF:0000107
(PMID:19342457)
Ensembl
RGD
PMID:19342457, PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 IMP PMID:19342457 UniProt PMID:19342457 RGD:4891166
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 ISO (PMID:19342457), (PMID:2022736), (PMID:8506298) RGD PMID:2022736, PMID:8506298, PMID:19342457 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 NOT ISO (PMID:9703385)
(PMID:19342457)
RGD PMID:9703385, PMID:19342457 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
cortisol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone ISO MGI:MGI:1857392 (MGI:MGI:1860037|PMID:10861000) RGD PMID:10861000 MGI:MGI:1860037 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 IDA
IBA
corticosterone
PMID:21873635
RGD
GO_Central
PMID:19665544, PMID:21873635 RGD:4891164, RGD:13792537
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 IDA
IBA
corticosterone, 18-hydroxycorticosterone
PMID:21873635
RGD
GO_Central
PMID:11832364, PMID:21873635 RGD:727991, RGD:13792537 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 ISO (MGI:MGI:1336546|PMID:10224232), (MGI:MGI:50073|PMID:1686470), (MGI:MGI:80407|PMID:8645611) RGD PMID:1686470, PMID:8645611, PMID:10224232 MGI:MGI:1336546, MGI:MGI:50073, MGI:MGI:80407 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 ISO
IEA
(MGI:MGI:77279|PMID:7588219)
GO_REF:0000041
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:7588219 GO_REF:0000041, GO_REF:0000107, MGI:MGI:77279 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:12460758 RGD:1625060 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
glucocorticoid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:12460758 RGD:1625060 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta IEA
ISO
GO_REF:0000107
(PMID:15790729)
Ensembl
RGD
PMID:15790729 GO_REF:0000107 NCBI chr14:83,053,041...83,062,424
Ensembl chr14:83,053,041...83,062,424
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 ISO
IEA
(PMID:19584291)
GO_REF:0000107
RGD
Ensembl
PMID:19584291 GO_REF:0000107 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp5 bone morphogenetic protein 5 ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Rest RE1-silencing transcription factor IMP
ISO
PMID:19342457
(PMID:19342457)
RGD PMID:19342457, PMID:19342457 RGD:4891166 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO MGI:MGI:2451290 (MGI:MGI:3696486|PMID:17234593) RGD PMID:17234593 MGI:MGI:3696486 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 IEA
ISO
GO_REF:0000107
(PMID:16981135)
Ensembl
RGD
PMID:16981135 GO_REF:0000107 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta ISO (PMID:24369117) RGD PMID:24369117 NCBI chr14:2,069,409...2,083,370
Ensembl chr14:2,069,409...2,083,370
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) ISO (PMID:18628520), (PMID:23132696)
(MGI:MGI:3623644|PMID:16356929)
RGD PMID:16356929, PMID:18628520, PMID:23132696 MGI:MGI:3623644 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO MGI:MGI:1857745 (MGI:MGI:74913|PMID:7628695) RGD PMID:7628695 MGI:MGI:74913 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
regulation of glucocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gal galanin and GMAP prepropeptide IMP RGD PMID:17273801 RGD:1624340 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 ISO (PMID:11146632) RGD PMID:11146632 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      primary metabolic process 10901
        lipid metabolic process 1378
          steroid metabolic process 323
            glucocorticoid metabolic process 26
              cortisol metabolic process + 12
              glucocorticoid biosynthetic process + 18
              glucocorticoid catabolic process + 2
              negative regulation of glucocorticoid metabolic process + 5
              positive regulation of glucocorticoid metabolic process + 1
              regulation of glucocorticoid metabolic process + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.