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ONTOLOGY REPORT - ANNOTATIONS

Term:siRNA-mediated gene silencing by mRNA destabilization
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Accession:GO:0090625 term browser browse the term
Definition:An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.
Synonyms:exact_synonym: mRNA cleavage involved in gene silencing by siRNA
 broad_synonym: gene silencing by mRNA cleavage


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siRNA-mediated gene silencing by mRNA destabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago1 argonaute RISC component 1 NOT|involved_in ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15260970), (PMID:22795694)		 Ensembl
RGD		 PMID:15260970 PMID:22795694 GO_REF:0000107 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 NOT|involved_in ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Ago4 argonaute RISC component 4 NOT|involved_in ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    biological regulation 13552
      regulation of biological quality 3386
        regulation of RNA stability 271
          regulation of mRNA stability 256
            mRNA destabilization 182
              siRNA-mediated gene silencing by mRNA destabilization 4
                siRNA-mediated long-distance post-transcriptional gene silencing 0
Path 2
Term Annotations click to browse term
  biological_process 20115
    biological regulation 13552
      regulation of biological process 13126
        regulation of metabolic process 6817
          regulation of biosynthetic process 5480
            regulation of cellular biosynthetic process 5384
              regulation of macromolecule biosynthetic process 5283
                regulation of gene expression 5164
                  negative regulation of gene expression 1383
                    mRNA catabolic process 336
                      regulation of mRNA catabolic process 271
                        regulation of mRNA stability 256
                          mRNA destabilization 182
                            siRNA-mediated gene silencing by mRNA destabilization 4
                              siRNA-mediated long-distance post-transcriptional gene silencing 0
paths to the root