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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell receptor signaling pathway
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Accession:GO:0050853 term browser browse the term
Definition:The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
Synonyms:exact_synonym: B cell receptor signalling pathway;   B lymphocyte receptor signaling pathway;   B lymphocyte receptor signalling pathway

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B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:11120811), (PMID:19228876) MGI PMID:11120811 PMID:19228876 NCBI chrNW_004624760:4,878,811...5,032,719
Ensembl chrNW_004624760:4,878,556...5,031,491 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO (PMID:9020138) UniProt PMID:9020138 NCBI chrNW_004624746:11,660,859...11,695,991
Ensembl chrNW_004624746:11,660,426...11,695,988 		JBrowse link
G Bcl2 BCL2 apoptosis regulator involved_in ISO (PMID:17875758) UniProt PMID:17875758 NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344 		JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:23555801)
(PMID:876631)		 ARUK-UCL
UniProt		 PMID:876631 PMID:23555801 NCBI chrNW_004624758:25,129,922...25,180,180
Ensembl chrNW_004624758:25,129,853...25,181,761 		JBrowse link
G Blnk B cell linker involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:7,565,169...7,681,102 JBrowse link
G Bmx BMX non-receptor tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624829:297,187...344,555
Ensembl chrNW_004624829:297,351...344,164 		JBrowse link
G Btk Bruton tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G Cd19 CD19 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9254656) TreeGrafter
MGI		 PMID:9254656 GO_REF:0000118 NCBI chrNW_004624782:12,844,148...12,850,770
Ensembl chrNW_004624782:12,845,432...12,850,576 		JBrowse link
G Cd38 CD38 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624755:16,035,412...16,093,610
Ensembl chrNW_004624755:16,034,771...16,093,866 		JBrowse link
G Cd79a CD79a molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1373499), (PMID:8626447) InterPro
MGI
TreeGrafter
Ensembl		 PMID:1373499 PMID:8626447 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624907:803,439...806,879
Ensembl chrNW_004624907:803,359...806,897 		JBrowse link
G Cd79b CD79b molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1373499), (PMID:8626447) InterPro
MGI
TreeGrafter		 PMID:1373499 PMID:8626447 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624849:1,429,446...1,432,835
Ensembl chrNW_004624849:1,429,912...1,432,955 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624765:12,449,205...12,454,324
Ensembl chrNW_004624765:12,449,205...12,454,324 		JBrowse link
G Fcrl5 Fc receptor like 5 acts_upstream_of ISO (PMID:23509253) MGI PMID:23509253 NCBI chrNW_004624794:3,217,505...3,248,486 JBrowse link
G Grb2 growth factor receptor bound protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624801:5,143,239...5,219,136
Ensembl chrNW_004624801:5,143,141...5,219,244 		JBrowse link
G Itk IL2 inducible T cell kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624733:32,125,005...32,198,901
Ensembl chrNW_004624733:32,127,388...32,198,869 		JBrowse link
G Klhl6 kelch like family member 6 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624730:72,916,601...72,972,204 JBrowse link
G Lat2 linker for activation of T cells family member 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624740:13,745,949...13,764,869 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7499277) TreeGrafter
MGI		 PMID:7499277 GO_REF:0000118 NCBI chrNW_004624764:15,469,582...15,495,351
Ensembl chrNW_004624764:15,472,685...15,495,351 		JBrowse link
G Lime1 Lck interacting transmembrane adaptor 1 acts_upstream_of_or_within ISO (PMID:16249387) MGI PMID:16249387 NCBI chrNW_004624741:29,390,743...29,393,457 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO (PMID:23509253)
(PMID:7499277)		 MGI PMID:7499277 PMID:23509253 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 acts_upstream_of_or_within ISO (PMID:9254656) MGI PMID:9254656 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISO (MGI:3829850|PMID:18955699) UniProt PMID:18955699 MGI:3829850 NCBI chrNW_004624743:8,072,871...8,235,174
Ensembl chrNW_004624743:8,072,673...8,235,252 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624904:2,508,576...2,575,505
Ensembl chrNW_004624904:2,508,799...2,578,609 		JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15143214) TreeGrafter
MGI		 PMID:15143214 GO_REF:0000118 NCBI chrNW_004624752:6,298,251...6,356,562
Ensembl chrNW_004624752:6,324,181...6,357,066 		JBrowse link
G Nfatc2 nuclear factor of activated T cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624790:4,366,440...4,484,279
Ensembl chrNW_004624790:4,366,406...4,484,432 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:17367755) MGI PMID:17367755 NCBI chrNW_004624830:5,334,273...5,430,887
Ensembl chrNW_004624830:5,333,616...5,408,723 		JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624838:1,384,337...1,387,602
Ensembl chrNW_004624838:1,384,204...1,390,205 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:17367755) MGI PMID:17367755 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Plcg2 phospholipase C gamma 2 involved_in ISO (PMID:15509800)
(MGI:1861532|PMID:10925250)
(PMID:11606584)		 ARUK-UCL
UniProt		 PMID:10925250 PMID:11606584 PMID:15509800 MGI:1861532 NCBI chrNW_004624746:5,678,057...5,824,663
Ensembl chrNW_004624746:5,682,666...5,821,855 		JBrowse link
G Plekha1 pleckstrin homology domain containing A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:24,299,199...24,365,459 JBrowse link
G Prkcb protein kinase C beta involved_in ISO (MGI:3626015|PMID:12118249) UniProt PMID:12118249 MGI:3626015 NCBI chrNW_004624782:8,974,995...9,287,609
Ensembl chrNW_004624782:8,974,765...9,287,702 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9254656)
(PMID:23509253)		 Ensembl
MGI		 PMID:9254656 PMID:23509253 GO_REF:0000107 NCBI chrNW_004624860:3,580,225...3,595,403
Ensembl chrNW_004624860:3,580,560...3,595,090 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 ISO (MGI:3687418|PMID:8692271)
(PMID:9254656)
(PMID:7499277)		 UniProt
MGI		 PMID:7499277 PMID:8692271 PMID:9254656 MGI:3687418 NCBI chrNW_004624798:1,700,732...1,814,603
Ensembl chrNW_004624798:1,699,541...1,814,656 		JBrowse link
G Rftn1 raftlin, lipid raft linker 1 involved_in ISO (PMID:12805216) UniProt PMID:12805216 NCBI chrNW_004624821:1,561,845...1,763,654
Ensembl chrNW_004624821:1,562,778...1,751,345 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:9233773)
(PMID:10872802)		 UniProt
MGI		 PMID:9233773 PMID:10872802 NCBI chrNW_004624740:15,266,759...15,289,420
Ensembl chrNW_004624740:15,266,653...15,278,165 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 involved_in ISO (PMID:24043312) MGI PMID:24043312 NCBI chrNW_004624738:20,466,120...20,591,966
Ensembl chrNW_004624738:20,466,117...20,591,910 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7499277), (PMID:8626447) Ensembl
MGI
TreeGrafter		 PMID:7499277 PMID:8626447 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624868:1,654,079...1,738,648
Ensembl chrNW_004624868:1,653,997...1,701,391 		JBrowse link
G Tec tec protein tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624761:18,695,168...18,824,045
Ensembl chrNW_004624761:18,695,177...18,822,078 		JBrowse link
G Txk TXK tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624761:18,841,795...18,897,564
Ensembl chrNW_004624761:18,841,795...18,897,458 		JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 involved_in ISO (PMID:17875758) UniProt PMID:17875758 NCBI chrNW_004624772:3,604,553...4,022,986
Ensembl chrNW_004624772:3,604,165...4,022,990 		JBrowse link
B cell receptor apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:15214043) BHF-UCL PMID:15214043 NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:23728777) MGI PMID:23728777 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd22 CD22 molecule involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624794:8,211,232...8,224,020
Ensembl chrNW_004624794:8,211,094...8,221,866 		JBrowse link
G Cd300a CD300a molecule involved_in ISO (PMID:21482706) UniProt PMID:21482706 NCBI chrNW_004624801:4,404,376...4,420,836
Ensembl chrNW_004624801:4,404,262...4,421,097 		JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb involved_in ISO (PMID:24169826) ARUK-UCL PMID:24169826 NCBI chrNW_004624826:97,605...112,101 JBrowse link
G Fcrl5 Fc receptor like 5 acts_upstream_of_or_within ISO (PMID:23509253) MGI PMID:23509253 NCBI chrNW_004624794:3,217,505...3,248,486 JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:5896692|PMID:28039360) UniProt PMID:28039360 MGI:5896692 NCBI chrNW_004624786:9,938,384...9,941,210
Ensembl chrNW_004624786:9,938,384...9,941,235 		JBrowse link
G Lpxn leupaxin involved_in ISO (MGI:3722965|PMID:17640867)
(PMID:17640867)		 UniProt PMID:17640867 MGI:3722965 NCBI chrNW_004624864:1,815,056...1,852,041
Ensembl chrNW_004624864:1,818,614...1,852,503 		JBrowse link
G Plcl2 phospholipase C like 2 acts_upstream_of_or_within ISO (PMID:14517301) MGI PMID:14517301 NCBI chrNW_004624821:2,132,075...2,316,624
Ensembl chrNW_004624821:2,131,851...2,315,934 		JBrowse link
positive regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:15,192,446...15,210,923
Ensembl chrNW_004624767:15,192,452...15,210,922 		JBrowse link
G Cmtm3 CKLF like MARVEL transmembrane domain containing 3 acts_upstream_of_or_within ISO (PMID:15196959) MGI PMID:15196959 NCBI chrNW_004624746:19,830,839...19,840,350
Ensembl chrNW_004624746:19,830,839...19,839,430 		JBrowse link
G Foxp1 forkhead box P1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624773:5,543,529...6,076,522
Ensembl chrNW_004624773:5,543,536...5,883,131 		JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624752:6,298,251...6,356,562
Ensembl chrNW_004624752:6,324,181...6,357,066 		JBrowse link
G Prkcb protein kinase C beta involved_in ISO (MGI:3700457|PMID:16301747) UniProt PMID:16301747 MGI:3700457 NCBI chrNW_004624782:8,974,995...9,287,609
Ensembl chrNW_004624782:8,974,765...9,287,702 		JBrowse link
G Prkch protein kinase C eta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:39,620,690...39,830,281
Ensembl chrNW_004624734:39,619,273...39,830,353 		JBrowse link
G Slc39a10 solute carrier family 39 member 10 acts_upstream_of_or_within ISO (PMID:25074919) MGI PMID:25074919 NCBI chrNW_004624854:1,163,025...1,280,717 JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624761:1,361,271...1,409,548
Ensembl chrNW_004624761:1,361,498...1,409,674 		JBrowse link
regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd19 CD19 molecule involved_in ISO (MGI:1100180|PMID:9382888)
(PMID:9382888)		 UniProt PMID:9382888 MGI:1100180 NCBI chrNW_004624782:12,844,148...12,850,770
Ensembl chrNW_004624782:12,845,432...12,850,576 		JBrowse link
G Fcmr Fc mu receptor involved_in ISO (MGI:5888941|PMID:28135254) UniProt PMID:28135254 MGI:5888941 NCBI chrNW_004624807:4,567,240...4,581,406 JBrowse link
G Gcsam germinal center associated signaling and motility involved_in ISO (PMID:23299888) UniProt PMID:23299888 NCBI chrNW_004624731:36,444,290...36,451,195 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      activation of immune response 460
        immune response-activating signaling pathway 405
          immune response-activating cell surface receptor signaling pathway 247
            antigen receptor-mediated signaling pathway 159
              B cell receptor signaling pathway 55
                B cell receptor apoptotic signaling pathway 2
                negative regulation of B cell receptor signaling pathway 7
                positive regulation of B cell receptor signaling pathway 8
                regulation of B cell receptor signaling pathway + 19
Path 2
Term Annotations click to browse term
  biological_process 15093
    biological regulation 10618
      regulation of biological process 10301
        regulation of immune system process 1351
          positive regulation of immune system process 948
            positive regulation of immune response 617
              activation of immune response 460
                immune response-activating signaling pathway 405
                  immune response-activating cell surface receptor signaling pathway 247
                    antigen receptor-mediated signaling pathway 159
                      B cell receptor signaling pathway 55
                        B cell receptor apoptotic signaling pathway 2
                        negative regulation of B cell receptor signaling pathway 7
                        positive regulation of B cell receptor signaling pathway 8
                        regulation of B cell receptor signaling pathway + 19
paths to the root