Lpxn (leupaxin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Lpxn (leupaxin) Heterocephalus glaber
Analyze
Symbol: Lpxn
Name: leupaxin
RGD ID: 18931313
Description: ENCODES a protein that exhibits transcription coregulator activity (ortholog); INVOLVED IN negative regulation of B cell receptor signaling pathway (ortholog); negative regulation of cell adhesion (ortholog); regulation of cell adhesion mediated by integrin (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); focal adhesion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248641,818,614 - 1,852,503 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248641,815,056 - 1,852,041 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Lpxn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248641,818,614 - 1,852,503 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248641,815,056 - 1,852,041 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
LPXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381158,526,871 - 58,578,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1158,526,871 - 58,578,220 (-)EnsemblGRCh38hg38GRCh38
GRCh371158,294,344 - 58,345,606 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,050,920 - 58,099,910 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,050,921 - 58,099,910NCBI
Celera1155,653,452 - 55,704,742 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1154,641,808 - 54,693,302 (-)NCBIHuRef
CHM1_11158,159,892 - 58,211,172 (-)NCBICHM1_1
T2T-CHM13v2.01158,476,376 - 58,527,888 (-)NCBIT2T-CHM13v2.0
Lpxn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391912,773,251 - 12,811,177 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1912,773,557 - 12,811,171 (+)EnsemblGRCm39 Ensembl
GRCm381912,795,887 - 12,833,813 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1912,796,193 - 12,833,807 (+)EnsemblGRCm38mm10GRCm38
MGSCv371912,873,099 - 12,908,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361912,865,628 - 12,900,827 (+)NCBIMGSCv36mm8
Celera1913,465,696 - 13,499,415 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.73NCBI
Lpxn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81219,353,319 - 219,387,743 (+)NCBIGRCr8
mRatBN7.21209,928,297 - 209,963,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1209,929,202 - 209,963,084 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1218,305,584 - 218,337,659 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01225,223,403 - 225,254,264 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01218,060,059 - 218,092,132 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01229,642,437 - 229,674,129 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1229,642,412 - 229,674,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01236,794,159 - 236,827,490 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,885,954 - 215,920,253 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11216,044,383 - 216,078,682 (+)NCBI
Celera1207,341,102 - 207,373,177 (+)NCBICelera
Cytogenetic Map1q43NCBI
Lpxn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555113,459,378 - 3,497,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555113,459,521 - 3,500,181 (-)NCBIChiLan1.0ChiLan1.0
LPXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2959,658,352 - 59,742,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11160,714,690 - 60,769,418 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01153,781,270 - 53,832,785 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11157,242,445 - 57,294,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1157,243,028 - 57,293,442 (-)Ensemblpanpan1.1panPan2
LPXN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11837,809,612 - 37,847,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1837,810,007 - 37,847,306 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1837,348,848 - 37,384,216 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01838,465,063 - 38,506,898 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11838,064,684 - 38,100,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01837,635,355 - 37,670,733 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01838,257,644 - 38,293,024 (+)NCBIUU_Cfam_GSD_1.0
Lpxn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494713,634,695 - 13,670,669 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365813,751,277 - 3,784,503 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365813,750,819 - 3,784,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl212,540,098 - 12,582,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1212,534,780 - 12,582,756 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2212,200,883 - 12,213,285 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LPXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,776,434 - 14,827,095 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,779,606 - 14,827,301 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038112,105,999 - 112,152,203 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000007572   ⟹   ENSHGLP00000007487
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248641,818,614 - 1,852,503 (+)Ensembl
RefSeq Acc Id: XM_004869741   ⟹   XP_004869798
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248641,818,248 - 1,852,041 (+)NCBI
RefSeq Acc Id: XM_013067493   ⟹   XP_012922947
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248641,817,530 - 1,852,041 (+)NCBI
RefSeq Acc Id: XM_021248348   ⟹   XP_021104007
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248641,821,638 - 1,852,041 (+)NCBI
RefSeq Acc Id: XM_021248349   ⟹   XP_021104008
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248641,815,056 - 1,852,041 (+)NCBI
RefSeq Acc Id: XM_021248350   ⟹   XP_021104009
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248641,823,805 - 1,852,041 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004869798 (Get FASTA)   NCBI Sequence Viewer  
  XP_012922947 (Get FASTA)   NCBI Sequence Viewer  
  XP_021104007 (Get FASTA)   NCBI Sequence Viewer  
  XP_021104008 (Get FASTA)   NCBI Sequence Viewer  
  XP_021104009 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA98808 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007487
Reference Protein Sequences
RefSeq Acc Id: XP_021104008   ⟸   XM_021248349
- Peptide Label: isoform X3
- UniProtKB: G5AP48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012922947   ⟸   XM_013067493
- Peptide Label: isoform X3
- UniProtKB: G5AP48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004869798   ⟸   XM_004869741
- Peptide Label: isoform X2
- UniProtKB: G5AP48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104007   ⟸   XM_021248348
- Peptide Label: isoform X1
- UniProtKB: G5AP48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104009   ⟸   XM_021248350
- Peptide Label: isoform X4
- UniProtKB: G5AP48 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000007487   ⟸   ENSHGLT00000007572


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005443 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007572 ENTREZGENE
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
InterPro Znf_LIM UniProtKB/TrEMBL
NCBI Gene Lpxn ENTREZGENE
PANTHER PDZ AND LIM DOMAIN PROTEIN ZASP UniProtKB/TrEMBL
  PDZ AND LIM DOMAIN PROTEIN ZASP UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt G5AP48 ENTREZGENE, UniProtKB/TrEMBL