Stap1 (signal transducing adaptor family member 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Stap1 (signal transducing adaptor family member 1) Heterocephalus glaber
Analyze
Symbol: Stap1
Name: signal transducing adaptor family member 1
RGD ID: 18905447
Description: ENCODES a protein that exhibits macrophage colony-stimulating factor receptor binding (ortholog); phosphotyrosine residue binding (ortholog); protein tyrosine kinase activator activity (ortholog); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (ortholog); cellular response to lipopolysaccharide (ortholog); negative regulation of macrophage chemotaxis (ortholog); ASSOCIATED WITH familial hypercholesterolemia (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: signal-transducing adaptor protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247611,361,498 - 1,409,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247611,361,271 - 1,409,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Stap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247611,361,498 - 1,409,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247611,361,271 - 1,409,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
STAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38467,558,727 - 67,607,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl467,558,727 - 67,607,337 (+)EnsemblGRCh38hg38GRCh38
GRCh37468,424,445 - 68,473,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36468,107,041 - 68,155,211 (+)NCBINCBI36Build 36hg18NCBI36
Celera465,886,843 - 65,935,009 (+)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef464,337,610 - 64,385,777 (+)NCBIHuRef
CHM1_1468,461,613 - 68,509,764 (+)NCBICHM1_1
T2T-CHM13v2.0471,001,810 - 71,050,419 (+)NCBIT2T-CHM13v2.0
Stap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,219,446 - 86,251,859 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,219,605 - 86,253,984 (+)EnsemblGRCm39 Ensembl
GRCm38586,071,584 - 86,106,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,071,746 - 86,106,125 (+)EnsemblGRCm38mm10GRCm38
MGSCv37586,500,853 - 86,533,018 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36587,146,389 - 87,178,554 (+)NCBIMGSCv36mm8
Celera583,303,792 - 83,335,974 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
Stap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81422,301,278 - 22,336,218 (-)NCBIGRCr8
mRatBN7.21421,950,466 - 21,981,395 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,952,496 - 21,981,245 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1422,309,093 - 22,337,798 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,621,523 - 23,650,227 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01422,152,622 - 22,181,325 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01423,575,400 - 23,604,984 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,576,085 - 23,604,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01423,479,674 - 23,508,287 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41423,734,558 - 23,764,077 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11423,734,558 - 23,764,077 (-)NCBI
Celera1421,426,012 - 21,455,282 (-)NCBICelera
Cytogenetic Map14p21NCBI
Stap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554475,293,227 - 5,330,187 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554475,292,708 - 5,345,214 (-)NCBIChiLan1.0ChiLan1.0
STAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2362,285,361 - 62,338,376 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1462,498,436 - 62,546,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0456,442,773 - 56,491,148 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1462,835,845 - 62,882,222 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl462,836,288 - 62,882,570 (-)Ensemblpanpan1.1panPan2
STAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11358,091,457 - 58,148,902 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1358,091,477 - 58,133,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1358,007,105 - 58,063,908 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01358,702,648 - 58,759,950 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1358,702,657 - 58,746,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11358,428,932 - 58,485,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01357,919,165 - 57,976,003 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01358,929,330 - 58,986,417 (+)NCBIUU_Cfam_GSD_1.0
Stap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528518,314,644 - 18,350,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936582877,474 - 913,770 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936582877,241 - 908,697 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl865,332,522 - 65,392,965 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1865,318,861 - 65,372,838 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2869,756,934 - 69,797,692 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.171,330,761 - 1,380,503 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl71,330,223 - 1,379,820 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660661,417,432 - 1,466,864 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000027407   ⟹   ENSHGLP00000027166
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247611,361,498 - 1,409,674 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000027408   ⟹   ENSHGLP00000027167
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247611,361,498 - 1,409,191 (-)Ensembl
RefSeq Acc Id: XM_004849833   ⟹   XP_004849890
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247611,361,271 - 1,409,548 (-)NCBI
RefSeq Acc Id: XM_021262290   ⟹   XP_021117949
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247611,361,272 - 1,409,544 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004849890 (Get FASTA)   NCBI Sequence Viewer  
  XP_021117949 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000027166
RefSeq Acc Id: XP_004849890   ⟸   XM_004849833
- Peptide Label: isoform X1
- UniProtKB: G5B221 (UniProtKB/TrEMBL),   A0AAX6PE57 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021117949   ⟸   XM_021262290
- Peptide Label: isoform X2
- UniProtKB: G5B221 (UniProtKB/TrEMBL),   A0AAX6TB35 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000027167   ⟸   ENSHGLT00000027408
Ensembl Acc Id: ENSHGLP00000027166   ⟸   ENSHGLT00000027407


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019321 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000027407 ENTREZGENE
Gene3D-CATH Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
  SH2 domain UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAP1/STAP2 UniProtKB/TrEMBL
  STAP1_SH2 UniProtKB/TrEMBL
NCBI Gene Stap1 ENTREZGENE
PANTHER SIGNAL-TRANSDUCING ADAPTOR PROTEIN 1 UniProtKB/TrEMBL
  SIGNAL-TRANSDUCING ADAPTOR PROTEIN-RELATED UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SH2 domain UniProtKB/TrEMBL
UniProt A0AAX6PE57 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TB35 ENTREZGENE, UniProtKB/TrEMBL
  G5B221 ENTREZGENE, UniProtKB/TrEMBL