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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of insulin receptor signaling pathway
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Accession:GO:0046627 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
Synonyms:exact_synonym: down regulation of insulin receptor signaling pathway;   downregulation of insulin receptor signaling pathway;   negative regulation of insulin receptor signalling pathway
 narrow_synonym: inhibition of insulin receptor signaling pathway

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negative regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHSG alpha 2-HS glycoprotein ISO RGD PMID:2766355 RGD:632173 NCBI chr15:2,809,234...2,818,382
Ensembl chr15:2,809,028...2,817,514 		JBrowse link
G ANKRD26 ankyrin repeat domain containing 26 acts_upstream_of_or_within ISO (PMID:21842266) MGI PMID:21842266 NCBI chr 9:26,601,072...26,693,238
Ensembl chr 9:26,599,966...26,693,217 		JBrowse link
G BLVRB biliverdin reductase B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:34,902,632...34,925,105
Ensembl chr 6:34,902,598...34,925,100 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:17849011), (PMID:7830796) BHF-UCL PMID:7830796 PMID:17849011 NCBI chr13:41,670,416...41,755,549 JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr13:41,681,213...41,755,382 JBrowse link
G GPR21 G protein-coupled receptor 21 acts_upstream_of_or_within ISO (PMID:22653059) MGI PMID:22653059 NCBI chr12:15,093,969...15,101,088 JBrowse link
G GRB10 growth factor receptor bound protein 10 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr21:8,022,483...8,225,339
Ensembl chr21:8,063,238...8,225,664 		JBrowse link
G GRB14 growth factor receptor bound protein 14 involved_in ISO
IEA		 RGD
Ensembl
TreeGrafter		 PMID:9748281 PMID:18657188 GO_REF:0000107 GO_REF:0000118 RGD:2307023 RGD:61620 NCBI chr10:49,952,835...50,085,274
Ensembl chr10:49,953,059...50,084,869 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:36,434,966...36,447,676
Ensembl chr 6:36,435,578...36,447,633 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in ISO PMID:8524413 BHF-UCL PMID:8524413 RGD:8554844 NCBI chr22:60,732,449...61,002,735
Ensembl chr22:60,733,465...60,997,239 		JBrowse link
G IL1B interleukin 1 beta involved_in ISO (PMID:16865359) BHF-UCL PMID:16865359 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G INPP5K inositol polyphosphate-5-phosphatase K involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:1,171,059...1,192,241
Ensembl chr16:1,170,899...1,191,965 		JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:11692174 RGD:2312443 NCBI chr 1:63,443,819...63,459,067
Ensembl chr 1:63,444,713...63,459,776 		JBrowse link
G IRS1 insulin receptor substrate 1 involved_in ISO PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr10:112,748,283...112,812,368 JBrowse link
G KANK1 KN motif and ankyrin repeat domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:78,775,214...79,015,538
Ensembl chr12:78,774,788...78,973,851 		JBrowse link
G LEP leptin involved_in ISO (PMID:14677856) CACAO PMID:14677856 NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220 		JBrowse link
G LONP1 lon peptidase 1, mitochondrial acts_upstream_of_or_within ISO (PMID:9813005) MGI PMID:9813005 NCBI chr 6:5,348,968...5,371,521
Ensembl chr 6:5,346,426...5,371,507 		JBrowse link
G MSTN myostatin involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:75,564,816...75,570,956
Ensembl chr10:75,565,152...75,570,528 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:53,501,152...53,595,500
Ensembl chr15:53,500,623...53,523,576 		JBrowse link
G NCL nucleolin acts_upstream_of_or_within ISO (PMID:9813005) MGI PMID:9813005 NCBI chr10:117,478,279...117,487,810 JBrowse link
G NCL nucleolin involved_in IEA Ensembl GO_REF:0000107 Ensembl chr10:117,477,904...117,486,774 JBrowse link
G NCOA5 nuclear receptor coactivator 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24332041) Ensembl
MGI		 PMID:24332041 GO_REF:0000107 NCBI chr 2:17,791,969...17,822,298
Ensembl chr 2:17,791,813...17,820,974 		JBrowse link
G NUCB2 nucleobindin 2 ISO RGD PMID:22486620 RGD:9831186 NCBI chr 1:47,634,425...47,690,723
Ensembl chr 1:47,634,531...47,689,011 		JBrowse link
G PID1 phosphotyrosine interaction domain containing 1 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr10:115,012,225...115,268,843
Ensembl chr10:115,012,168...115,268,884 		JBrowse link
G PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:22,306,307...22,482,074
Ensembl chr 9:22,306,312...22,481,954 		JBrowse link
G PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:67,391,786...67,429,560
Ensembl chr16:67,406,981...67,427,691 		JBrowse link
G PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:53,499,360...53,511,610
Ensembl chr11:53,499,432...53,509,799 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO RGD PMID:20501641 RGD:6484547 NCBI chr 4:39,516,307...39,553,627 JBrowse link
G PRKCA protein kinase C alpha acts_upstream_of_or_within ISO (PMID:11923480) MGI PMID:11923480 NCBI chr16:54,638,548...55,144,372
Ensembl chr16:54,642,729...54,948,256 		JBrowse link
G PRKCB protein kinase C beta involved_in ISO PMID:11714718 UniProt PMID:11714718 RGD:8553365 NCBI chr 5:21,558,608...21,940,536
Ensembl chr 5:21,558,441...21,943,864 		JBrowse link
G PRKCD protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:14,561,401...14,592,877
Ensembl chr22:14,565,282...14,592,873 		JBrowse link
G PRKCQ protein kinase C theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:6,532,438...6,675,708
Ensembl chr 9:6,532,319...6,621,487 		JBrowse link
G PRKCZ protein kinase C zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:129,367,309...129,502,681
Ensembl chr20:129,365,679...129,485,818 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:71,302,082...71,400,201
Ensembl chr18:71,310,577...71,345,960 		JBrowse link
G PTPRE protein tyrosine phosphatase receptor type E involved_in ISO PMID:15738637
(PMID:18006633)		 UniProt PMID:15738637 PMID:18006633 RGD:8553759 NCBI chr 9:120,511,812...120,691,820
Ensembl chr 9:120,646,898...120,690,230 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO RGD PMID:8557682 RGD:1642757 NCBI chr20:89,192,426...89,284,989
Ensembl chr20:89,191,660...89,284,970 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:17,137,896...17,328,836
Ensembl chr 1:17,135,907...17,328,590 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO RGD PMID:18073321 RGD:2298860 NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15249583) Ensembl
MGI		 PMID:15249583 GO_REF:0000107 NCBI chr16:33,498,098...33,556,553
Ensembl chr16:33,497,392...33,556,453 		JBrowse link
G RPS6KB2 ribosomal protein S6 kinase B2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15249583) MGI
Ensembl		 PMID:15249583 GO_REF:0000107 NCBI chr 1:6,828,413...6,836,176
Ensembl chr 1:6,828,682...6,836,143 		JBrowse link
G SLC27A4 solute carrier family 27 member 4 involved_in ISO (PMID:25603556) ARUK-UCL PMID:25603556 NCBI chr12:9,769,242...9,788,214 JBrowse link
G SLC27A4 solute carrier family 27 member 4 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:9,769,974...9,786,464 JBrowse link
G SOCS1 suppressor of cytokine signaling 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15169905) Ensembl
MGI		 PMID:15169905 GO_REF:0000107 NCBI chr 5:10,731,866...10,733,745
Ensembl chr 5:10,732,350...10,732,991 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15169905) Ensembl
MGI		 PMID:15169905 GO_REF:0000107 NCBI chr16:70,353,099...70,356,401
Ensembl chr16:70,354,746...70,355,423 		JBrowse link
G TNS2 tensin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:49,163,217...49,183,110
Ensembl chr11:49,169,060...49,182,611 		JBrowse link
G TRIM72 tripartite motif containing 72 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23965929) Ensembl
MGI		 PMID:23965929 GO_REF:0000107 NCBI chr 5:27,903,202...27,915,950
Ensembl chr 5:27,903,479...27,918,527 		JBrowse link
G TSC2 TSC complex subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:1,946,534...1,985,168
Ensembl chr 5:1,946,927...1,987,682 		JBrowse link
G YBX1 Y-box binding protein 1 ISO RGD PMID:12554649 RGD:727501 NCBI chr20:90,229,927...90,250,213 JBrowse link
G ZNF592 zinc finger protein 592 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9813005) Ensembl
MGI		 PMID:9813005 GO_REF:0000107 NCBI chr29:3,554,095...3,611,845
Ensembl chr29:3,553,618...3,611,834 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17042
    cellular process 16559
      signal transduction 5610
        negative regulation of signal transduction 1451
          negative regulation of insulin receptor signaling pathway 49
            negative regulation of insulin receptor signaling pathway by insulin receptor internalization 0
Path 2
Term Annotations click to browse term
  biological_process 17042
    biological regulation 11829
      regulation of biological process 11439
        signaling 6120
          signal transduction 5610
            cell surface receptor signaling pathway 2755
              enzyme-linked receptor protein signaling pathway 977
                cell surface receptor protein tyrosine kinase signaling pathway 628
                  insulin receptor signaling pathway 181
                    regulation of insulin receptor signaling pathway 84
                      negative regulation of insulin receptor signaling pathway 49
                        negative regulation of insulin receptor signaling pathway by insulin receptor internalization 0
paths to the root