PRKCB (protein kinase C beta) - Rat Genome Database

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Gene: PRKCB (protein kinase C beta) Chlorocebus sabaeus
Analyze
Symbol: PRKCB
Name: protein kinase C beta
RGD ID: 18778638
Description: ENCODES a protein that exhibits ATP binding (inferred); calcium channel regulator activity (inferred); calcium,diacylglycerol-dependent serine/threonine kinase activity (inferred); INVOLVED IN calcium ion transport (ortholog); cellular response to carbohydrate stimulus (ortholog); dibenzo-p-dioxin metabolic process (ortholog); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); Alzheimer's disease (ortholog); autistic disorder (ortholog); FOUND IN brush border membrane (ortholog); calyx of Held (ortholog); centrosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein kinase C beta type
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,558,608 - 21,940,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,558,441 - 21,943,864 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660687,834,678 - 8,241,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
apoptotic process  (IEA)
B cell activation  (IEA)
B cell receptor signaling pathway  (IEA)
calcium ion transport  (IEA,ISO)
cellular response to carbohydrate stimulus  (IEA,ISO)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
dibenzo-p-dioxin metabolic process  (ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
negative regulation of D-glucose transmembrane transport  (IEA)
negative regulation of insulin receptor signaling pathway  (ISO)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of insulin secretion  (IEA)
positive regulation of odontogenesis of dentin-containing tooth  (ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IEA)
presynaptic modulation of chemical synaptic transmission  (IEA)
protein kinase C signaling  (IEA)
protein phosphorylation  (ISO)
regulation of D-glucose transmembrane transport  (IEA)
regulation of dopamine secretion  (ISO)
regulation of growth  (ISO)
regulation of primary metabolic process  (IEA)
regulation of synaptic vesicle exocytosis  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to angiotensin  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component
brush border membrane  (ISO)
calyx of Held  (IEA,ISO)
centrosome  (ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
membrane  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)
plasma membrane  (IEA,ISO)
presynaptic cytosol  (IEA,ISO)
spectrin  (IEA)

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PRKCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,558,608 - 21,940,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,558,441 - 21,943,864 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660687,834,678 - 8,241,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PRKCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,835,983 - 24,220,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,835,983 - 24,220,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371623,847,304 - 24,231,932 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,754,823 - 24,139,063 (+)NCBINCBI36Build 36hg18NCBI36
Build 341623,754,822 - 24,139,063NCBI
Celera1622,625,642 - 23,009,889 (+)NCBICelera
Cytogenetic Map16p12.2-p12.1NCBI
HuRef1621,938,281 - 22,322,666 (+)NCBIHuRef
CHM1_11624,859,040 - 25,244,985 (+)NCBICHM1_1
T2T-CHM13v2.01624,111,361 - 24,497,130 (+)NCBIT2T-CHM13v2.0
Prkcb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,888,327 - 122,233,625 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,887,974 - 122,233,625 (+)EnsemblGRCm39 Ensembl
GRCm387122,289,104 - 122,634,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,288,751 - 122,634,402 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,432,639 - 129,777,916 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367122,080,445 - 122,419,795 (+)NCBIMGSCv36mm8
Celera7122,177,656 - 122,520,472 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.75NCBI
Prkcb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,263,397 - 186,594,743 (+)NCBIGRCr8
mRatBN7.21176,832,173 - 177,163,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,160,371 - 185,491,641 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,346,335 - 192,677,604 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,030,688 - 185,362,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,233,569 - 192,575,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,295,067 - 199,639,140 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,117,512 - 181,459,856 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,257,931 - 181,599,763 (+)NCBI
Celera1174,677,501 - 174,871,327 (+)NCBICelera
Cytogenetic Map1q36NCBI
Prkcb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,395,109 - 2,710,934 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,395,494 - 2,710,522 (+)NCBIChiLan1.0ChiLan1.0
PRKCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21825,253,309 - 25,633,275 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11629,772,855 - 30,153,604 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01613,888,936 - 14,268,759 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11624,091,284 - 24,466,701 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1624,091,289 - 24,466,203 (+)Ensemblpanpan1.1panPan2
PRKCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1621,742,970 - 22,064,360 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl621,742,973 - 22,065,185 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,304,828 - 23,630,068 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0621,880,650 - 22,206,417 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl621,880,653 - 22,206,393 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1621,685,773 - 22,010,753 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0621,587,647 - 21,912,745 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0621,982,425 - 22,308,075 (-)NCBIUU_Cfam_GSD_1.0
Prkcb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,339,861 - 120,631,378 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,437,715 - 8,728,716 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365018,410,273 - 8,729,238 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl321,995,231 - 22,383,264 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1321,995,227 - 22,383,628 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2322,949,682 - 23,174,763 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Prkcb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,974,765 - 9,287,702 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,974,995 - 9,287,609 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRKCB
10519 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000004677   ⟹   ENSCSAP00000002926
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl521,558,441 - 21,943,864 (+)Ensembl
RefSeq Acc Id: XM_007988069   ⟹   XP_007986260
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1521,558,608 - 21,936,647 (+)NCBI
Vero_WHO_p1.0NW_0236660687,834,678 - 8,241,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988070   ⟹   XP_007986261
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1521,558,608 - 21,940,536 (+)NCBI
Vero_WHO_p1.0NW_0236660687,834,678 - 8,241,859 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007986260 (Get FASTA)   NCBI Sequence Viewer  
  XP_007986261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002926
  ENSCSAP00000002926.1
RefSeq Acc Id: XP_007986261   ⟸   XM_007988070
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R2T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007986260   ⟸   XM_007988069
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCSAP00000002926   ⟸   ENSCSAT00000004677


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006641 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004677.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  cPKC_beta UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Protein_kinase_C_a/b/g UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene PRKCB ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF PKC_alpha UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/TrEMBL
  DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A0D9R2T7 ENTREZGENE, UniProtKB/TrEMBL