Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of lymphocyte differentiation
go back to main search page
Accession:GO:0045620 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of lymphocyte differentiation;   downregulation of lymphocyte differentiation
 narrow_synonym: inhibition of lymphocyte differentiation
 related_synonym: negative regulation of lymphocyte development

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
negative regulation of lymphocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo7 F-box protein 7 acts_upstream_of_or_within ISO (PMID:21652635) MGI PMID:21652635 NCBI chrNW_004624750:1,977,666...1,997,408
Ensembl chrNW_004624750:1,977,761...1,997,231 		JBrowse link
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli3 GLI family zinc finger 3 involved_in ISO (MGI:4355451|PMID:19667090) BHF-UCL PMID:19667090 MGI:4355451 NCBI chrNW_004624740:18,961,395...19,238,760
Ensembl chrNW_004624740:18,975,596...19,235,900 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624823:5,959,329...5,965,584
Ensembl chrNW_004624823:5,959,448...5,964,769 		JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within ISO (PMID:10981962) MGI PMID:10981962 NCBI chrNW_004624800:2,202,986...2,215,309
Ensembl chrNW_004624800:2,203,393...2,212,068 		JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (PMID:16618805) MGI PMID:16618805 NCBI chrNW_004624776:10,407,083...10,516,350
Ensembl chrNW_004624776:10,435,850...10,517,066 		JBrowse link
G Hmgb3 high mobility group box 3 acts_upstream_of_or_within ISO (PMID:12714519) MGI PMID:12714519 NCBI chrNW_004624923:1,245,898...1,250,571 JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:18523151) MGI PMID:18523151 NCBI chrNW_004624846:2,281,292...2,283,596
Ensembl chrNW_004624846:2,277,961...2,283,571 		JBrowse link
G Sfrp1 secreted frizzled related protein 1 involved_in ISO (MGI:3814493|PMID:18941195)
(PMID:18941195)		 UniProt PMID:18941195 MGI:3814493 NCBI chrNW_004624780:2,133,105...2,172,301
Ensembl chrNW_004624780:2,132,960...2,174,508 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chrNW_004624746:19,204,415...19,264,217
Ensembl chrNW_004624746:19,204,392...19,264,194 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:22473704) UniProt PMID:22473704 NCBI chrNW_004624776:7,858,400...7,862,716
Ensembl chrNW_004624776:7,793,259...7,863,184 		JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chrNW_004624764:9,192,067...9,218,617
Ensembl chrNW_004624764:9,191,556...9,248,252 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc4a2 solute carrier family 4 member 2 involved_in ISO (MGI:6840447|PMID:24515893) UniProt PMID:24515893 MGI:6840447 NCBI chrNW_004624800:5,545,380...5,560,789 JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in ISO (MGI:6140589|PMID:24880459) UniProt PMID:24880459 MGI:6140589 NCBI chrNW_004624824:8,444,877...8,446,628 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:5446998|PMID:22730529), (MGI:6140589|PMID:24880459) UniProt PMID:22730529 PMID:24880459 MGI:5446998 MGI:6140589 NCBI chrNW_004624885:2,474,427...2,489,024
Ensembl chrNW_004624885:2,475,727...2,489,030 		JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:12421925) BHF-UCL PMID:12421925 NCBI chrNW_004624731:15,262,480...15,269,196
Ensembl chrNW_004624731:15,263,274...15,269,743 		JBrowse link
G Clec4g C-type lectin domain family 4 member G involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23487419) Ensembl
MGI		 PMID:23487419 GO_REF:0000107 NCBI chrNW_004624828:775,114...778,526
Ensembl chrNW_004624828:773,569...778,615 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of_or_within ISO (PMID:16230479) MGI PMID:16230479 NCBI chrNW_004624795:3,373,313...3,391,509
Ensembl chrNW_004624795:3,373,000...3,391,602 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624823:5,959,329...5,965,584
Ensembl chrNW_004624823:5,959,448...5,964,769 		JBrowse link
G Tmem131l transmembrane 131 like involved_in ISO (PMID:23690469) UniProt PMID:23690469 NCBI chrNW_004624858:4,772,450...4,931,064
Ensembl chrNW_004624858:4,772,457...4,932,593 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen like 2 acts_upstream_of_or_within ISO (PMID:29341118) MGI PMID:29341118 NCBI chrNW_004624739:26,501,149...26,507,305
Ensembl chrNW_004624739:26,503,965...26,507,305 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20709292) Ensembl
MGI		 PMID:20709292 GO_REF:0000107 NCBI chrNW_004624832:7,220,739...7,225,146
Ensembl chrNW_004624832:7,221,064...7,224,615 		JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 acts_upstream_of_or_within ISO (PMID:20709292) MGI PMID:20709292 NCBI chrNW_004624901:2,554,303...2,562,436
Ensembl chrNW_004624901:2,554,048...2,561,826 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:15240705) MGI PMID:15240705 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5320871|PMID:22080863) UniProt PMID:22080863 MGI:5320871 NCBI chrNW_004624770:19,808,400...19,877,494
Ensembl chrNW_004624770:19,808,400...19,876,503 		JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (IN blood group) involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chrNW_004624767:11,938,452...12,024,970
Ensembl chrNW_004624767:11,938,028...12,025,069 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624765:12,449,205...12,454,324
Ensembl chrNW_004624765:12,449,205...12,454,324 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO RGD PMID:30287503 RGD:38549580 NCBI chrNW_004624740:14,940,161...14,941,561
Ensembl chrNW_004624740:14,939,445...14,941,819 		JBrowse link
G Irf1 interferon regulatory factor 1 involved_in ISO (MGI:3803082|PMID:18641303) UniProt PMID:18641303 MGI:3803082 NCBI chrNW_004624733:39,596,565...39,603,428
Ensembl chrNW_004624733:39,596,501...39,603,526 		JBrowse link
G Lag3 lymphocyte activating 3 involved_in ISO (MGI:3510279|PMID:15485628) UniProt PMID:15485628 MGI:3510279 NCBI chrNW_004624860:3,454,587...3,461,649
Ensembl chrNW_004624860:3,456,347...3,461,592 		JBrowse link
G Mdk midkine involved_in ISO (PMID:22323540) UniProt PMID:22323540 NCBI chrNW_004624767:2,171,096...2,173,436
Ensembl chrNW_004624767:2,171,096...2,173,512 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) BHF-UCL PMID:18713990 MGI:3806904 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
negative regulation of T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule acts_upstream_of_or_within ISO (PMID:7679955) MGI PMID:7679955 NCBI chrNW_004624774:9,699,876...9,708,871
Ensembl chrNW_004624774:9,700,393...9,709,514 		JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 acts_upstream_of_or_within ISO (PMID:12794108) MGI PMID:12794108 NCBI chrNW_004624747:19,321,842...19,352,661
Ensembl chrNW_004624747:19,318,465...19,352,473 		JBrowse link
G Ifnb1 interferon beta 1 involved_in ISO (PMID:20554961) UniProt PMID:20554961 NCBI chrNW_004624736:25,099,061...25,099,746 JBrowse link
G Nrarp NOTCH regulated ankyrin repeat protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12794108) Ensembl
MGI		 PMID:12794108 GO_REF:0000107 NCBI chrNW_004624760:670,796...672,679
Ensembl chrNW_004624760:670,837...671,181 		JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO (PMID:16290204) MGI PMID:16290204 NCBI chrNW_004624901:407,240...410,902
Ensembl chrNW_004624901:406,257...410,866 		JBrowse link
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:12421925) BHF-UCL PMID:12421925 NCBI chrNW_004624731:15,262,480...15,269,196
Ensembl chrNW_004624731:15,263,274...15,269,743 		JBrowse link
G Foxj1 forkhead box J1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624801:6,025,756...6,030,487
Ensembl chrNW_004624801:6,025,793...6,030,486 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624823:5,959,329...5,965,584
Ensembl chrNW_004624823:5,959,448...5,964,769 		JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of_or_within ISO (PMID:11931770) MGI PMID:11931770 NCBI chrNW_004624794:10,172,789...10,180,693
Ensembl chrNW_004624794:10,168,792...10,179,510 		JBrowse link
G Rag2 recombination activating 2 ISO RGD PMID:30206106 RGD:38508903 NCBI chrNW_004624767:10,678,547...10,680,130
Ensembl chrNW_004624767:10,678,359...10,680,132 		JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within ISO (PMID:10981962) MGI PMID:10981962 NCBI chrNW_004624800:2,202,986...2,215,309
Ensembl chrNW_004624800:2,203,393...2,212,068 		JBrowse link
G Zc3h8 zinc finger CCCH-type containing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624749:137,599...169,641
Ensembl chrNW_004624749:137,721...169,324 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) UniProt PMID:24463518 MGI:5565031 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chrNW_004624908:1,371,595...1,383,879
Ensembl chrNW_004624908:1,371,595...1,383,879 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) UniProt PMID:24463518 MGI:5565031 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) UniProt PMID:23169781 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Il2 interleukin 2 involved_in ISO (MGI:5634593|PMID:25642768) BHF-UCL PMID:25642768 MGI:5634593 NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) MGI PMID:18792410 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:12,025,206...12,074,548 JBrowse link
G Smad7 SMAD family member 7 involved_in ISO (MGI:5634593|PMID:25642768) BHF-UCL PMID:25642768 MGI:5634593 NCBI chrNW_004624778:12,415,364...12,444,882
Ensembl chrNW_004624778:12,415,282...12,444,835 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO (PMID:23034280) MGI PMID:23034280 NCBI chrNW_004624885:2,474,427...2,489,024
Ensembl chrNW_004624885:2,475,727...2,489,030 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:20,224,919...20,234,108
Ensembl chrNW_004624764:20,224,906...20,234,629 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 CD69 molecule involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004624860:4,345,497...4,364,251
Ensembl chrNW_004624860:4,345,232...4,365,817 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) UniProt PMID:20696842 NCBI chrNW_004624908:1,371,595...1,383,879
Ensembl chrNW_004624908:1,371,595...1,383,879 		JBrowse link
G Lgals1 galectin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624752:10,220,115...10,223,434
Ensembl chrNW_004624752:10,219,872...10,223,317 		JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624749:28,959,682...28,980,428
Ensembl chrNW_004624749:28,960,593...28,980,428 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chrNW_004624771:8,711,093...8,722,518
Ensembl chrNW_004624771:8,711,017...8,722,539 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624811:765,338...782,203
Ensembl chrNW_004624811:764,940...782,198 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) UniProt PMID:24463518 MGI:5565031 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624835:4,223,252...4,227,892
Ensembl chrNW_004624835:4,223,511...4,227,979 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) UniProt PMID:12242343 MGI:3687909 NCBI chrNW_004624738:28,150,004...28,217,850
Ensembl chrNW_004624738:28,150,664...28,216,389 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO (PMID:15917799) MGI PMID:15917799 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15225
    immune system process 2122
      leukocyte activation 908
        lymphocyte activation 737
          lymphocyte differentiation 394
            negative regulation of lymphocyte differentiation 57
              negative regulation of B cell differentiation + 5
              negative regulation of T cell differentiation + 50
              negative regulation of natural killer cell differentiation + 2
Path 2
Term Annotations click to browse term
  biological_process 15225
    developmental process 6175
      cellular developmental process 4138
        cell differentiation 4137
          cell development 2981
            hemopoiesis 931
              leukocyte differentiation 597
                mononuclear cell differentiation 483
                  lymphocyte differentiation 394
                    regulation of lymphocyte differentiation 186
                      negative regulation of lymphocyte differentiation 57
                        negative regulation of B cell differentiation + 5
                        negative regulation of T cell differentiation + 50
                        negative regulation of natural killer cell differentiation + 2
paths to the root