Cd74 (CD74 molecule) - Rat Genome Database

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Gene: Cd74 (CD74 molecule) Heterocephalus glaber
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Symbol: Cd74
Name: CD74 molecule
RGD ID: 18921363
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); CD4 receptor binding (ortholog); cytokine binding (ortholog); INVOLVED IN antigen processing and presentation (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); blocking of symbiont entry into host cell (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN endoplasmic reticulum (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HLA class II histocompatibility antigen gamma chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,700,393 - 9,709,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,699,876 - 9,708,871 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation  (IEA,ISO)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (ISO)
blocking of symbiont entry into host cell  (ISO)
canonical NF-kappaB signal transduction  (ISO)
chaperone cofactor-dependent protein refolding  (ISO)
cytokine-mediated signaling pathway  (IEA)
defense response  (ISO)
immune response  (IEA)
immunoglobulin mediated immune response  (ISO)
intracellular protein transport  (IEA,ISO)
macrophage migration inhibitory factor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA)
negative regulation of mature B cell apoptotic process  (ISO)
negative regulation of peptide secretion  (ISO)
negative regulation of T cell differentiation  (ISO)
negative thymic T cell selection  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of cytokine-mediated signaling pathway  (IEA)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of kinase activity  (ISO)
positive regulation of macrophage cytokine production  (IEA)
positive regulation of macrophage migration inhibitory factor signaling pathway  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of monocyte differentiation  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of type 2 immune response  (IEA)
positive regulation of viral entry into host cell  (ISO)
positive thymic T cell selection  (ISO)
prostaglandin biosynthetic process  (ISO)
protein stabilization  (ISO)
protein trimerization  (IEA)
protein-containing complex assembly  (ISO)
response to type II interferon  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
T cell activation involved in immune response  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cd74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,700,393 - 9,709,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,699,876 - 9,708,871 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CD74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,401,639 - 150,412,910 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,401,637 - 150,412,969 (-)EnsemblGRCh38hg38GRCh38
GRCh375149,781,202 - 149,792,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,761,393 - 149,772,525 (-)NCBINCBI36Build 36hg18NCBI36
Build 345149,761,396 - 149,772,511NCBI
Celera5145,862,277 - 145,873,409 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5144,928,781 - 144,940,080 (-)NCBIHuRef
CHM1_15149,213,619 - 149,224,915 (-)NCBICHM1_1
T2T-CHM13v2.05150,938,180 - 150,949,451 (-)NCBIT2T-CHM13v2.0
Cd74
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391860,936,921 - 60,945,724 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1860,936,920 - 60,945,724 (+)EnsemblGRCm39 Ensembl
GRCm381860,803,849 - 60,812,652 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,803,848 - 60,812,652 (+)EnsemblGRCm38mm10GRCm38
MGSCv371860,963,503 - 60,972,306 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361860,929,247 - 60,938,021 (+)NCBIMGSCv36mm8
Celera1862,088,874 - 62,098,436 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
Cd74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,527,071 - 56,536,406 (+)NCBIGRCr8
mRatBN7.21854,256,757 - 54,266,003 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,256,778 - 54,266,003 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,345,511 - 56,354,694 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,060,123 - 57,069,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01854,880,697 - 54,889,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,071,420 - 56,080,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,071,478 - 56,080,849 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,305,827 - 55,315,246 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,756,511 - 56,765,711 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,828,786 - 56,837,940 (+)NCBI
Celera1852,411,586 - 52,420,786 (+)NCBICelera
RH 3.4 Map18525.0RGD
Cytogenetic Map18q12.1NCBI
Cd74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,129,254 - 4,137,826 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,129,151 - 4,138,336 (+)NCBIChiLan1.0ChiLan1.0
CD74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,629,969 - 145,641,243 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,769,515 - 143,780,789 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,825,635 - 145,836,916 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,830,311 - 151,841,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,830,311 - 151,841,334 (-)Ensemblpanpan1.1panPan2
CD74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,689,745 - 58,698,421 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,689,752 - 58,698,151 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,456,154 - 58,464,833 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,170,613 - 59,179,292 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,170,623 - 59,198,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,959,149 - 58,967,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,073,563 - 59,082,236 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,604,607 - 59,613,287 (+)NCBIUU_Cfam_GSD_1.0
Cd74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,948,591 - 142,958,314 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,522,751 - 4,531,750 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,522,576 - 4,532,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,402,211 - 151,409,833 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,402,210 - 151,409,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CD74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,008,802 - 53,022,953 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2353,009,394 - 53,022,923 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,695,767 - 24,707,325 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000005398   ⟹   ENSHGLP00000005329
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247749,700,393 - 9,709,514 (-)Ensembl
RefSeq Acc Id: XM_013075754   ⟹   XP_012931208
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247749,699,876 - 9,708,871 (-)NCBI
RefSeq Acc Id: XM_013075755   ⟹   XP_012931209
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247749,699,876 - 9,708,867 (-)NCBI
Protein Sequences
Protein RefSeqs XP_012931208 (Get FASTA)   NCBI Sequence Viewer  
  XP_012931209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000005329
RefSeq Acc Id: XP_012931208   ⟸   XM_013075754
- Peptide Label: isoform X1
- UniProtKB: G5C391 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012931209   ⟸   XM_013075755
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000005329   ⟸   ENSHGLT00000005398


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003902 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000005398 ENTREZGENE
Gene3D-CATH MHC class II-associated invariant chain, trimerisation domain UniProtKB/TrEMBL
  Thyroglobulin type-1 UniProtKB/TrEMBL
InterPro CD74_antigen UniProtKB/TrEMBL
  MHC-II_Gamma/Thyroglobulin UniProtKB/TrEMBL
  MHC_II-assoc_invar/CLIP_MHC-bd UniProtKB/TrEMBL
  MHC_II-assoc_invar_chain UniProtKB/TrEMBL
  MHC_II-assoc_invariant_trimer UniProtKB/TrEMBL
  MHCII_invariant_trimer_sf UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/TrEMBL
NCBI Gene Cd74 ENTREZGENE
PANTHER HLA CLASS II GAMMA CHAIN UniProtKB/TrEMBL
  HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN UniProtKB/TrEMBL
Pfam MHC2-interact UniProtKB/TrEMBL
  MHCassoc_trimer UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
PIRSF CD74_antigen UniProtKB/TrEMBL
PRINTS CD74ANTIGEN UniProtKB/TrEMBL
PROSITE THYROGLOBULIN_1_1 UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/TrEMBL
SMART SM00211 UniProtKB/TrEMBL
Superfamily-SCOP Class II MHC-associated invariant chain ectoplasmic trimerization domain UniProtKB/TrEMBL
  Thyroglobulin type-1 domain UniProtKB/TrEMBL
UniProt G5C391 ENTREZGENE, UniProtKB/TrEMBL