Cd74 (CD74 molecule) - Rat Genome Database

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Gene: Cd74 (CD74 molecule) Ictidomys tridecemlineatus
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Symbol: Cd74
Name: CD74 molecule
RGD ID: 12485129
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); CD4 receptor binding (ortholog); cytokine binding (ortholog); INVOLVED IN antigen processing and presentation (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); cell population proliferation (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Breast Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: CD74 molecule, transcript variant X1; CD74 molecule, transcript variant X2; HLA class II histocompatibility antigen gamma chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,948,591 - 142,958,314 (+)NCBI
SpeTri2.0NW_0049365044,522,576 - 4,532,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation  (ISO)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (ISO)
cell population proliferation  (ISO)
chaperone cofactor-dependent protein refolding  (ISO)
defense response  (ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
immunoglobulin mediated immune response  (ISO)
intracellular protein transport  (ISO)
macrophage migration inhibitory factor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
negative regulation of mature B cell apoptotic process  (ISO)
negative regulation of peptide secretion  (ISO)
negative regulation of T cell differentiation  (ISO)
negative regulation of viral entry into host cell  (ISO)
negative thymic T cell selection  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of cytokine-mediated signaling pathway  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of kinase activity  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of macrophage migration inhibitory factor signaling pathway  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of monocyte differentiation  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of type 2 immune response  (ISO)
positive regulation of viral entry into host cell  (ISO)
positive thymic T cell selection  (ISO)
prostaglandin biosynthetic process  (ISO)
protein stabilization  (ISO)
protein-containing complex assembly  (ISO)
response to interferon-gamma  (ISO)
signal transduction involved in regulation of gene expression  (ISO)

References

Genomics

Comparative Map Data
Cd74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,948,591 - 142,958,314 (+)NCBI
SpeTri2.0NW_0049365044,522,576 - 4,532,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5150,400,041 - 150,412,969 (-)EnsemblGRCh38hg38GRCh38
GRCh385150,401,637 - 150,412,910 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375149,779,604 - 149,792,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,761,393 - 149,772,525 (-)NCBINCBI36hg18NCBI36
Build 345149,761,396 - 149,772,511NCBI
Celera5145,862,277 - 145,873,409 (-)NCBI
Cytogenetic Map5q33.1NCBI
HuRef5144,928,781 - 144,940,080 (-)NCBIHuRef
CHM1_15149,213,619 - 149,224,915 (-)NCBICHM1_1
Cd74
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391860,936,921 - 60,945,724 (+)NCBIGRCm39mm39
GRCm39 Ensembl1860,936,920 - 60,945,724 (+)Ensembl
GRCm381860,803,849 - 60,812,652 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,803,848 - 60,812,652 (+)EnsemblGRCm38mm10GRCm38
MGSCv371860,963,503 - 60,972,306 (+)NCBIGRCm37mm9NCBIm37
MGSCv361860,929,247 - 60,938,021 (+)NCBImm8
Celera1862,088,874 - 62,098,436 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
Cd74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21854,256,757 - 54,266,003 (+)NCBI
Rnor_6.0 Ensembl1856,071,478 - 56,080,849 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01856,071,420 - 56,080,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01855,305,827 - 55,315,246 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,756,511 - 56,765,711 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11856,828,786 - 56,837,940 (+)NCBI
Celera1852,411,586 - 52,420,786 (+)NCBICelera
RH 3.4 Map18525.0RGD
Cytogenetic Map18q12.1NCBI
Cd74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,129,254 - 4,137,826 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,129,151 - 4,138,336 (+)NCBIChiLan1.0ChiLan1.0
CD74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15151,830,311 - 151,841,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,830,311 - 151,841,334 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05145,825,635 - 145,836,916 (-)NCBIMhudiblu_PPA_v0panPan3
CD74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,689,745 - 58,698,421 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,689,752 - 58,698,151 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,456,154 - 58,464,833 (+)NCBI
ROS_Cfam_1.0459,170,613 - 59,179,292 (+)NCBI
UMICH_Zoey_3.1458,959,149 - 58,967,827 (+)NCBI
UNSW_CanFamBas_1.0459,073,563 - 59,082,236 (+)NCBI
UU_Cfam_GSD_1.0459,604,607 - 59,613,287 (+)NCBI
CD74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12151,402,210 - 151,409,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CD74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,008,802 - 53,022,953 (-)NCBI
ChlSab1.1 Ensembl2353,009,394 - 53,022,923 (-)Ensembl
Vero_WHO_p1.0NW_02366603424,695,767 - 24,707,325 (+)NCBI
Cd74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247749,699,876 - 9,708,871 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005324159   ⟹   XP_005324216
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213142,948,591 - 142,958,314 (+)NCBI
SpeTri2.0NW_0049365044,522,576 - 4,532,289 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013358181   ⟹   XP_013213635
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213142,948,595 - 142,958,314 (+)NCBI
SpeTri2.0NW_0049365044,522,580 - 4,532,289 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005324216 (Get FASTA)   NCBI Sequence Viewer  
  XP_013213635 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3265966 (Get FASTA)   NCBI Sequence Viewer  
  KAG3265967 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005324216   ⟸   XM_005324159
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013213635   ⟸   XM_013358181
- Peptide Label: isoform X2
- Sequence:
Protein Domains
Thyroglobulin type-1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009017 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000008077 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009014 UniProtKB/TrEMBL
Gene3D-CATH 1.10.870.10 UniProtKB/TrEMBL
  4.10.800.10 UniProtKB/TrEMBL
InterPro CD74_antigen UniProtKB/TrEMBL
  MHC_II-assoc_invar/CLIP_MHC-bd UniProtKB/TrEMBL
  MHC_II-assoc_invar_chain UniProtKB/TrEMBL
  MHC_II-assoc_invariant_trimer UniProtKB/TrEMBL
  MHCII_invariant_trimer_sf UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/TrEMBL
NCBI Gene Cd74 ENTREZGENE
Pfam MHC2-interact UniProtKB/TrEMBL
  MHCassoc_trimer UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
PIRSF CD74_antigen UniProtKB/TrEMBL
PRINTS CD74ANTIGEN UniProtKB/TrEMBL
PROSITE THYROGLOBULIN_1_1 UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/TrEMBL
SMART SM00211 UniProtKB/TrEMBL
Superfamily-SCOP SSF48305 UniProtKB/TrEMBL
  SSF57610 UniProtKB/TrEMBL
UniProt I3MCR9_ICTTR UniProtKB/TrEMBL