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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway in response to hydrogen peroxide
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Accession:GO:0036481 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2).
Synonyms:exact_synonym: hydrogen peroxide-induced intrinsic apoptotic signaling pathway;   intrinsic apoptotic signaling pathway in response to H2O2
 broad_synonym: hydrogen peroxide-induced apoptosis
 related_synonym: H2O2-induced intrinsic apoptotic signaling pathway

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intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP2K4 mitogen-activated protein kinase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:11,366,610...11,485,411
Ensembl chr16:11,366,751...11,486,125 		JBrowse link
G PDCD10 programmed cell death 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:21,697,366...21,748,760
Ensembl chr15:21,706,675...21,749,470 		JBrowse link
G STK25 serine/threonine kinase 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:127,571,024...127,580,628
Ensembl chr10:127,571,665...127,580,071 		JBrowse link
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in ISO (PMID:21177249) ParkinsonsUK-UCL PMID:21177249 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:111,902,135...111,919,082
Ensembl chr20:111,902,765...111,919,069 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CA3 carbonic anhydrase 3 ISO RGD PMID:29559661 RGD:408427357 NCBI chr 8:80,805,296...80,816,127
Ensembl chr 8:80,805,134...80,816,190 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:111,902,135...111,919,082
Ensembl chr20:111,902,765...111,919,069 		JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:82,800,211...82,805,769
Ensembl chr23:82,798,085...82,805,936 		JBrowse link
G TRAP1 TNF receptor associated protein 1 involved_in ISO PMID:17579517 ParkinsonsUK-UCL PMID:17579517 RGD:8693356 NCBI chr 5:3,339,954...3,405,218
Ensembl chr 5:3,340,040...3,405,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19803
    cellular process 19325
      signal transduction 5636
        intracellular signal transduction 3027
          intrinsic apoptotic signaling pathway 365
            intrinsic apoptotic signaling pathway in response to oxidative stress 84
              intrinsic apoptotic signaling pathway in response to hydrogen peroxide 9
                negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 6
                neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 3
                positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 0
                regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 6
Path 2
Term Annotations click to browse term
  biological_process 19803
    response to stimulus 8821
      response to stress 4090
        cellular response to stress 1976
          cellular response to chemical stress 408
            cellular response to oxidative stress 328
              cellular response to reactive oxygen species 199
                programmed cell death in response to reactive oxygen species 21
                  hydrogen peroxide-mediated programmed cell death 20
                    intrinsic apoptotic signaling pathway in response to hydrogen peroxide 9
                      negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 6
                      neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 3
                      positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 0
                      regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 6
paths to the root