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ONTOLOGY REPORT - ANNOTATIONS

Term:megakaryocyte development
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Accession:GO:0035855 term browser browse the term
Definition:The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
Synonyms:exact_synonym: megakaryocyte cell development


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megakaryocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi1 abl interactor 1 acts_upstream_of_or_within IMP (PMID:17664349) MGI PMID:17664349 NCBI chr 2:22,830,085...22,930,207
Ensembl chr 2:22,830,085...22,930,253 		JBrowse link
G Ep300 E1A binding protein p300 acts_upstream_of_or_within IMP (PMID:18684867) MGI PMID:18684867 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Fli1 Friend leukemia integration 1 acts_upstream_of_or_within IMP (PMID:16757682) MGI PMID:16757682 NCBI chr 9:32,333,500...32,454,292
Ensembl chr 9:32,333,500...32,454,157 		JBrowse link
G Flna filamin, alpha involved_in NAS (PMID:23336709) ComplexPortal PMID:23336709 NCBI chr  X:73,267,067...73,293,787
Ensembl chr  X:73,267,067...73,293,426 		JBrowse link
G Gp1ba glycoprotein 1b, alpha polypeptide involved_in NAS
IMP		 (PMID:23336709)
(PMID:18187573)		 ComplexPortal PMID:18187573 PMID:23336709 NCBI chr11:70,529,928...70,534,812
Ensembl chr11:70,529,948...70,532,862 		JBrowse link
G Gp1bb glycoprotein Ib, beta polypeptide involved_in NAS
IMP		 (PMID:23336709)
(PMID:18187573)		 ComplexPortal PMID:18187573 PMID:23336709 NCBI chr16:18,439,069...18,441,153
Ensembl chr16:18,439,067...18,441,153 		JBrowse link
G Gp5 glycoprotein 5 platelet involved_in IMP
NAS		 (PMID:18187573)
(PMID:23336709)		 ComplexPortal PMID:18187573 PMID:23336709 NCBI chr16:30,126,503...30,129,599
Ensembl chr16:30,126,503...30,129,597 		JBrowse link
G Gp9 glycoprotein 9 platelet involved_in IMP
NAS		 (PMID:18187573)
(PMID:23336709)		 ComplexPortal PMID:18187573 PMID:23336709 NCBI chr 6:87,753,115...87,756,768
Ensembl chr 6:87,755,054...87,756,750 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase involved_in IMP (PMID:15067126) UniProt PMID:15067126 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382 		JBrowse link
G Med1 mediator complex subunit 1 involved_in IMP (PMID:11724781) BHF-UCL PMID:11724781 NCBI chr11:98,042,980...98,084,121
Ensembl chr11:98,042,980...98,084,119 		JBrowse link
G Meis1 Meis homeobox 1 acts_upstream_of_or_within IMP (PMID:20203303) MGI PMID:20203303 NCBI chr11:18,830,428...18,968,992
Ensembl chr11:18,829,817...18,968,985 		JBrowse link
G Mpig6b megakaryocyte and platelet inhibitory receptor G6b acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:23112346) MGI
GO_Central		 PMID:23112346 GO_REF:0000033 NCBI chr17:35,281,669...35,285,761
Ensembl chr17:35,281,669...35,285,160 		JBrowse link
G Nbeal2 neurobeachin-like 2 acts_upstream_of_or_within IMP (PMID:23861251)
(PMID:25258341)		 MGI PMID:23861251 PMID:25258341 NCBI chr 9:110,453,857...110,483,229
Ensembl chr 9:110,453,857...110,483,229 		JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha involved_in IMP (PMID:16434494) UniProt PMID:16434494 NCBI chr 2:18,847,066...19,003,101
Ensembl chr 2:18,847,066...19,002,937 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within IMP (PMID:23509158) MGI PMID:23509158 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 acts_upstream_of_or_within IMP (PMID:23509158) MGI PMID:23509158 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Rabgap1l RAB GTPase activating protein 1-like involved_in NAS (PMID:10585558) BHF-UCL PMID:10585558 NCBI chr 1:160,046,744...160,621,046
Ensembl chr 1:160,046,744...160,620,781 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in IMP (PMID:15337790) ARUK-UCL PMID:15337790 NCBI chr 5:121,953,544...121,975,706
Ensembl chr 5:121,953,551...121,975,709 		JBrowse link
G Srf serum response factor acts_upstream_of_or_within IMP (PMID:20525922)
(PMID:20709909)		 MGI PMID:20525922 PMID:20709909 NCBI chr17:46,857,764...46,869,194
Ensembl chr17:46,859,255...46,867,101 		JBrowse link
G Tal1 T cell acute lymphocytic leukemia 1 acts_upstream_of_or_within IMP (PMID:16763211) MGI PMID:16763211 NCBI chr 4:114,913,623...114,928,952
Ensembl chr 4:114,913,623...114,928,952 		JBrowse link
G Tesc tescalcin NOT|involved_in IMP (PMID:22285131) UniProt PMID:22285131 NCBI chr 5:118,165,808...118,199,943
Ensembl chr 5:118,165,808...118,199,943 		JBrowse link
G Thpo thrombopoietin involved_in ISO GO_Central GO_REF:0000119 NCBI chr16:20,543,204...20,553,261
Ensembl chr16:20,543,204...20,553,261 		JBrowse link
G Vps33b vacuolar protein sorting 33B involved_in IMP (PMID:25947942) UniProt PMID:25947942 NCBI chr 7:79,919,369...79,941,323
Ensembl chr 7:79,919,397...79,941,502 		JBrowse link
G Wasf2 WASP family, member 2 acts_upstream_of_or_within IMP (PMID:17664349) MGI PMID:17664349 NCBI chr 4:132,857,843...132,927,067
Ensembl chr 4:132,857,816...132,927,067 		JBrowse link
G Zfp385a zinc finger protein 385A acts_upstream_of_or_within
involved_in		 IMP
NAS		 (PMID:11927637)
(PMID:10585558)		 MGI
BHF-UCL		 PMID:10585558 PMID:11927637 NCBI chr15:103,222,322...103,248,537
Ensembl chr15:103,222,322...103,248,520 		JBrowse link
G Zfpm1 zinc finger protein, multitype 1 acts_upstream_of_or_within IMP (PMID:20010697) MGI PMID:20010697 NCBI chr 8:123,008,595...123,064,601
Ensembl chr 8:123,008,880...123,063,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    developmental process 7491
      anatomical structure development 6960
        cell development 3504
          hemopoiesis 1173
            myeloid cell development 109
              megakaryocyte development 26
Path 2
Term Annotations click to browse term
  biological_process 28635
    cellular process 18389
      cellular developmental process 5146
        cell differentiation 5145
          cell development 3504
            hemopoiesis 1173
              myeloid cell differentiation 552
                megakaryocyte differentiation 66
                  megakaryocyte development 26
paths to the root