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Gene: Flna (filamin, alpha) Mus musculus
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Symbol: Flna
Name: filamin, alpha
Description: Exhibits potassium channel regulator activity and protein kinase C binding activity. Involved in several processes, including circulatory system development; early endosome to late endosome transport; and regulation of ion transmembrane transport. Localizes to several cellular components, including the Z disc; brush border; and trans-Golgi network. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in FG syndrome; craniosynostosis; mitral valve prolapse; osteochondrodysplasia; and periventricular nodular heterotopia. Is expressed in several structures, including brain; gut; lung; sternum; and tail dermomyotome. Orthologous to human FLNA (filamin A); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; Rho/Rac/Cdc42 mediated signaling pathway; integrin mediated signaling pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ABP-280; actin-binding protein 280; alpha-filamin; dilated pupils 2; Dilp2; endothelial actin-binding protein; F730004A14Rik; filamin A; filamin-1; filamin-A; FLN-A; Fln1; GENA 379; non-muscle filamin
Orthologs:
Homo sapiens (human) : FLNA (filamin A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flna (filamin A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flna (filamin A)
Pan paniscus (bonobo/pygmy chimpanzee) : FLNA (filamin A)
Canis lupus familiaris (dog) : FLNA (filamin A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flna (filamin A)
Sus scrofa (pig) : FLNA (filamin A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 EnsemblX74,223,461 - 74,249,820 (-)Ensembl
GRCm38X74,223,461 - 74,249,854 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X71,468,800 - 71,491,873 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X71,468,800 - 71,491,873 (-)NCBImm8
CeleraX65,477,570 - 65,500,684 (-)NCBICelera
Cytogenetic MapX A7.3NCBI
cM MapX37.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Flna
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558370
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.