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beta-catenin destruction complex - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:beta-catenin destruction complex
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Accession:GO:0030877 term browser browse the term
Definition:A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
Comment:Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Synonyms:exact_synonym: APC-Axin-1-beta-catenin complex;   Axin-APC-beta-catenin-GSK3B complex;   BDC;   beta-catenin degradation complex
 narrow_synonym: 23S APC complex
 alt_id: GO:0034742;   GO:0034747

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beta-catenin destruction complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway part_of ISO
ISS
IBA 		(PMID:16188939), (PMID:8638126), (PMID:9601641)
GO_REF:0000024
GO_REF:0000033 		RGD
UniProt
GO_Central		 PMID:8638126 PMID:9601641 PMID:16188939 GO_REF:0000024 GO_REF:0000033 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:10,043,010...10,065,037
Ensembl chr 7:9,392,336...9,414,310 		JBrowse link
G Axin1 axin 1 part_of IDA
IEA
IBA
ISO 		PMID:10228155
GO_REF:0000107
GO_REF:0000033
(PMID:16188939), (PMID:18593713), (PMID:19759537), (PMID:9601641)
(PMID:10318824), (PMID:11955436) 		Ensembl
GO_Central
RGD		 PMID:9601641 PMID:10318824 PMID:11955436 PMID:16188939 PMID:18593713 More... GO_REF:0000033 GO_REF:0000107, RGD:8553327 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axin2 axin 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Cacybp calcyclin binding protein part_of ISO (PMID:16085652) RGD PMID:16085652 NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 part_of ISO
ISS 		(PMID:11955436)
GO_REF:0000024 		RGD
ParkinsonsUK-UCL		 PMID:11955436 GO_REF:0000024 NCBI chr18:57,285,156...57,320,540
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Ctnnb1 catenin beta 1 part_of ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:10318824)
(PMID:16188939), (PMID:18593713), (PMID:8638126) 		UniProt
Ensembl
RGD		 PMID:8638126 PMID:10318824 PMID:16188939 PMID:18593713 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 part_of ISO
IBA
IEA 		(PMID:16188939)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:16188939 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:165,245,019...165,293,994
Ensembl chr 5:159,961,928...160,010,939 		JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 located_in ISO (PMID:22470507) RGD PMID:22470507 NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta part_of IDA
IEA
IBA
ISO 		PMID:10228155
GO_REF:0000107
GO_REF:0000033
(PMID:10318824)
(PMID:16188939), (PMID:18593713), (PMID:8638126), (PMID:9601641) 		Ensembl
GO_Central
RGD		 PMID:8638126 PMID:9601641 PMID:10318824 PMID:16188939 PMID:18593713 More... GO_REF:0000033 GO_REF:0000107, RGD:8553327 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 part_of ISS
ISO
IEA 		GO_REF:0000024
(PMID:16085652)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:16085652 GO_REF:0000024 GO_REF:0000107 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21349
    protein-containing complex 6834
      catalytic complex 1961
        beta-catenin destruction complex 11
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