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ONTOLOGY REPORT - ANNOTATIONS

Term:AP-2 adaptor complex
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Accession:GO:0030122 term browser browse the term
Definition:A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
Synonyms:exact_synonym: HA2;   HA2 clathrin adaptor


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AP-2 adaptor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 part_of ISO
IBA		 (PMID:23676497)
GO_REF:0000033		 RGD
GO_Central		 PMID:23676497 GO_REF:0000033 NCBI chr 1:95,384,306...95,414,170
Ensembl chr 1:95,384,309...95,414,147 		JBrowse link
G Ap2a2 adaptor related protein complex 2 subunit alpha 2 part_of ISO
IMP
IEA
IBA		 (PMID:23676497)
PMID:12086608
GO_REF:0000117
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:23676497 PMID:12086608 GO_REF:0000033 GO_REF:0000117, RGD:12793054 NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603 		JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 part_of ISO (PMID:12086608), (PMID:23676497)
(PMID:23676497)		 RGD PMID:12086608 PMID:23676497 NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 part_of IDA
ISO
IBA		 PMID:12086608
(PMID:23676497)
GO_REF:0000033		 RGD
GO_Central		 PMID:23676497 PMID:12086608 GO_REF:0000033, RGD:12793054 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140 		JBrowse link
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 part_of IDA
IEA
ISO		 PMID:2040623
GO_REF:0000002
GO_REF:0000107
(PMID:12086608)		 InterPro
Ensembl
RGD		 PMID:12086608 PMID:7593184 PMID:2040623 GO_REF:0000002 GO_REF:0000107, RGD:2306270, RGD:727584 NCBI chr 1:77,417,496...77,428,903
Ensembl chr 1:77,417,477...77,428,905 		JBrowse link
G Btbd8 BTB domain containing 8 located_in IDA PMID:29262337 UniProt PMID:29262337 RGD:13601995 NCBI chr14:2,265,187...2,338,426
Ensembl chr14:2,266,454...2,334,393 		JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 part_of ISO (PMID:17626015) RGD PMID:17626015 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221 		JBrowse link
G Sgip1 SH3GL interacting endocytic adaptor 1 part_of ISS
IEA
ISO		 PMID:17626015
GO_REF:0000107
(PMID:17626015)		 Ensembl
RGD		 PMID:17626015 PMID:17626015 GO_REF:0000107, RGD:8554282 NCBI chr 5:117,536,752...117,734,593
Ensembl chr 5:117,537,746...117,734,575 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 part_of IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:14724281 GO_REF:0000033, RGD:2317430 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Ston1 stonin 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:5,843,186...5,892,557
Ensembl chr 6:5,843,185...5,892,449 		JBrowse link
G Ston2 stonin 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376 		JBrowse link
G Tbc1d5 TBC1 domain family, member 5 located_in ISO (PMID:24603492) RGD PMID:24603492 NCBI chr 9:3,503,328...4,017,131
Ensembl chr 9:3,513,623...4,016,913 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20827
    protein-containing complex 6555
      membrane protein complex 1410
        plasma membrane protein complex 670
          AP-2 adaptor complex 12
Path 2
Term Annotations click to browse term
  cellular_component 20827
    cellular anatomical structure 20627
      organelle 13970
        membrane-bounded organelle 12557
          vesicle 2242
            intracellular vesicle 2058
              cytoplasmic vesicle 2049
                coated vesicle 237
                  coated vesicle membrane 112
                    vesicle coat 61
                      clathrin vesicle coat 30
                        clathrin coat of endocytic vesicle 13
                          AP-2 adaptor complex 12
paths to the root