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ONTOLOGY REPORT - ANNOTATIONS

Term:histone deacetylase activity, NAD-dependent
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Accession:GO:0017136 term browser browse the term
Definition:Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide.
Comment:Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7); and the Class IV protein (HDAC11 in human). Except for Class III enzymes, the mechanism is a metal-dependent hydrolysis of the acetylated substrate. The Class III HDACs use NAD+ as a reactant to deacetylate acetyl lysine residues of protein substrates forming nicotinamide, the deacetylated product, and the metabolite 2'-O-acetyl-ADP-ribose. Therefore, Class III are classified as transferases (EC:2) and others are hydrolases (EC:3).
Synonyms:exact_synonym: NAD-dependent histone lysine deacetylase activity
 narrow_synonym: sirtuin
 broad_synonym: histone deacetylase activity
 related_synonym: SIR2


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histone deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT1 sirtuin 1 enables ISO
IBA
IDA
IEA		 (PMID:12006491), (PMID:15469825), (PMID:16079181), (PMID:16959573), (PMID:28497810) RGD
GO_Central
BHF-UCL
Ensembl		 PMID:12006491 PMID:15469825 PMID:16079181 PMID:16959573 PMID:19356683 More... GO_REF:0000033 GO_REF:0000107 RGD:2316170 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables
NOT|enables		 IEA
IBA
IDA		 (PMID:11427894), (PMID:12697818), (PMID:24177535)
(PMID:24177535)		 InterPro
GO_Central
UniProt		 PMID:11427894 PMID:12697818 PMID:24177535 GO_REF:0000002 GO_REF:0000033 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT4 sirtuin 4 enables IBA GO_Central GO_REF:0000033 NCBI chr12:120,291,780...120,313,249
Ensembl chr12:120,302,316...120,313,249 		JBrowse link
G SIRT5 sirtuin 5 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:13,574,274...13,615,158
Ensembl chr 6:13,574,227...13,615,158 		JBrowse link
G SIRT6 sirtuin 6 enables ISS
IDA		 (PMID:24043303), (PMID:27912097) UniProt PMID:24043303 PMID:27912097 GO_REF:0000024 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
histone H3K14 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT1 sirtuin 1 enables IDA
IEA		 (PMID:15469825) BHF-UCL
UniProt		 PMID:15469825 GO_REF:0000003 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables IEA UniProt GO_REF:0000003 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 enables IEA UniProt GO_REF:0000003 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT6 sirtuin 6 enables IEA UniProt GO_REF:0000003 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G SIRT7 sirtuin 7 enables IEA UniProt GO_REF:0000003 NCBI chr17:81,911,939...81,918,176
Ensembl chr17:81,911,939...81,921,323 		JBrowse link
histone H3K18 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT1 sirtuin 1 enables IEA UniProt GO_REF:0000003 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables IEA UniProt GO_REF:0000003 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 enables IEA UniProt GO_REF:0000003 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT6 sirtuin 6 enables IDA
IEA		 (PMID:27043296) UniProt
Ensembl		 PMID:27043296 GO_REF:0000003 GO_REF:0000107 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G SIRT7 sirtuin 7 enables IEA
IBA
IMP
IDA		 (PMID:28655758)
(PMID:22722849), (PMID:26907567), (PMID:30420520), (PMID:30653310), (PMID:35939806)		 Ensembl
UniProt
GO_Central		 PMID:22722849 PMID:26907567 PMID:28655758 PMID:30420520 PMID:30653310 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr17:81,911,939...81,918,176
Ensembl chr17:81,911,939...81,921,323 		JBrowse link
histone H3K4 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT1 sirtuin 1 enables IEA UniProt GO_REF:0000003 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables IEA UniProt GO_REF:0000003 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 enables IEA UniProt GO_REF:0000003 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT6 sirtuin 6 enables IEA UniProt GO_REF:0000003 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G SIRT7 sirtuin 7 enables IEA UniProt GO_REF:0000003 NCBI chr17:81,911,939...81,918,176
Ensembl chr17:81,911,939...81,921,323 		JBrowse link
histone H3K56 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT1 sirtuin 1 enables IEA UniProt GO_REF:0000003 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables IEA UniProt GO_REF:0000003 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 enables IEA UniProt GO_REF:0000003 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT6 sirtuin 6 enables IDA
IEA		 (PMID:23911928), (PMID:26456828), (PMID:26898756), (PMID:27912097), (PMID:30374165) UniProt
Ensembl		 PMID:23911928 PMID:26456828 PMID:26898756 PMID:27912097 PMID:30374165 GO_REF:0000003 GO_REF:0000107 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G SIRT7 sirtuin 7 enables IEA UniProt GO_REF:0000003 NCBI chr17:81,911,939...81,918,176
Ensembl chr17:81,911,939...81,921,323 		JBrowse link
histone H3K9 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT1 sirtuin 1 enables IEA
IDA
ISS		 (PMID:15469825) Ensembl
UniProt
BHF-UCL		 PMID:15469825 GO_REF:0000003 GO_REF:0000024 GO_REF:0000107 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables IEA UniProt GO_REF:0000003 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 enables IEA UniProt GO_REF:0000003 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT6 sirtuin 6 enables IEA
IBA
IMP
IDA		 (PMID:29555651)
(PMID:18337721), (PMID:23892288), (PMID:26456828), (PMID:30374165), (PMID:33067423)		 Ensembl
UniProt
GO_Central		 PMID:18337721 PMID:23892288 PMID:26456828 PMID:29555651 PMID:30374165 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G SIRT7 sirtuin 7 enables IEA UniProt GO_REF:0000003 NCBI chr17:81,911,939...81,918,176
Ensembl chr17:81,911,939...81,921,323 		JBrowse link
histone H4K16 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT1 sirtuin 1 enables IDA
IEA		 (PMID:15469825) BHF-UCL
UniProt		 PMID:15469825 GO_REF:0000003 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SIRT2 sirtuin 2 enables IDA
IEA		 (PMID:16648462) UniProt PMID:16648462 GO_REF:0000003 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SIRT3 sirtuin 3 enables IEA UniProt GO_REF:0000003 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SIRT6 sirtuin 6 enables IEA UniProt GO_REF:0000003 NCBI chr19:4,174,109...4,182,563
Ensembl chr19:4,174,109...4,182,566 		JBrowse link
G SIRT7 sirtuin 7 enables IEA UniProt GO_REF:0000003 NCBI chr17:81,911,939...81,918,176
Ensembl chr17:81,911,939...81,921,323 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19683
    catalytic activity 6024
      catalytic activity, acting on a protein 2462
        protein lysine deacetylase activity 25
          histone deacetylase activity 25
            histone deacetylase activity, NAD-dependent 7
              histone H3K14 deacetylase activity, NAD-dependent 5
              histone H3K18 deacetylase activity, NAD-dependent 5
              histone H3K4 deacetylase activity, NAD-dependent 5
              histone H3K56 deacetylase activity, NAD-dependent 5
              histone H3K9 deacetylase activity, NAD-dependent 5
              histone H4K16 deacetylase activity, NAD-dependent 5
Path 2
Term Annotations click to browse term
  molecular_function 19683
    catalytic activity 6024
      deacylase activity 71
        deacetylase activity 40
          protein lysine deacetylase activity 25
            histone deacetylase activity 25
              histone deacetylase activity, NAD-dependent 7
                histone H3K14 deacetylase activity, NAD-dependent 5
                histone H3K18 deacetylase activity, NAD-dependent 5
                histone H3K4 deacetylase activity, NAD-dependent 5
                histone H3K56 deacetylase activity, NAD-dependent 5
                histone H3K9 deacetylase activity, NAD-dependent 5
                histone H4K16 deacetylase activity, NAD-dependent 5
paths to the root