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ONTOLOGY REPORT - ANNOTATIONS

Term:histone deacetylase activity
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Accession:GO:0004407 term browser browse the term
Definition:Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
Synonyms:xref: EC:3.5.1.98;   MetaCyc:3.5.1.98-RXN;   RHEA:58196;   Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones";   reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin";   reactome:R-HSA-2545253 "Deacetylation of cohesin";   reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone";   reactome:R-HSA-3782637 "HDAC8 deacetylates histones";   reactome:R-HSA-3782655 "HDAC10 deacetylates histone";   reactome:R-HSA-427514 "eNoSC deacetylates histone H3";   reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3";   reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53"


show annotations for term's descendants           Sort by:
histone deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 contributes_to IDA RGD PMID:17079677 RGD:5688291 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G ENSRNOG00000069033 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 7:78,933,181...78,934,754 JBrowse link
G Hdac1 histone deacetylase 1 enables ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000118
GO_REF:0000033
(PMID:12590135), (PMID:16762839), (PMID:17996965), (PMID:19182791), (PMID:28497810)
GO_REF:0000002
(MGI:3687778|PMID:10615135), (MGI:5288521|PMID:21960634), (MGI:6867113|PMID:30279482)		 UniProt
TreeGrafter
GO_Central
RGD
InterPro		 PMID:10615135 PMID:12590135 PMID:16762839 PMID:17996965 PMID:19182791 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:3687778 MGI:5288521 MGI:6867113 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac10 histone deacetylase 10 enables ISO
IEA		 (PMID:11861901)
GO_REF:0000107
(PMID:11739383)		 RGD
Ensembl		 PMID:11739383 PMID:11861901 GO_REF:0000107 NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228 		JBrowse link
G Hdac11 histone deacetylase 11 enables ISO
IBA		 (PMID:11948178)
GO_REF:0000033		 RGD
GO_Central		 PMID:11948178 GO_REF:0000033 NCBI chr 4:123,645,873...123,667,407
Ensembl chr 4:123,650,157...123,667,405 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables ISO
IBA		 (PMID:16642021), (PMID:28497810)
MGI:1916782 (MGI:3811960|PMID:18754010), (MGI:5567917|PMID:15226430), (MGI:6867113|PMID:30279482), (PMID:12975471)
GO_REF:0000033		 RGD
GO_Central		 PMID:12975471 PMID:15226430 PMID:16642021 PMID:18754010 PMID:28497810 More... GO_REF:0000033 MGI:3811960 MGI:5567917 MGI:6867113 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 contributes_to
enables		 IDA
ISO
IEA		 (MGI:6867113|PMID:30279482), (PMID:15832170), (PMID:17464331)
GO_REF:0000118
GO_REF:0000002
(PMID:16924111), (PMID:18326024), (PMID:28497810)
GO_REF:0000116
GO_REF:0000003		 RGD
TreeGrafter
InterPro
RHEA
UniProt		 PMID:15832170 PMID:16924111 PMID:17464331 PMID:18326024 PMID:28497810 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000118 MGI:6867113, RGD:5688291 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA
ISO		 GO_REF:0000104
(PMID:10220385), (PMID:10869435), (PMID:12590135)		 UniProt
RGD		 PMID:10220385 PMID:10869435 PMID:12590135 GO_REF:0000104 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables ISO (PMID:10869435)
(MGI:1889866|PMID:10640276)		 RGD PMID:10640276 PMID:10869435 MGI:1889866 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac6 histone deacetylase 6 enables ISO (PMID:10220385), (PMID:23322205)
(MGI:5605128|PMID:24882211), (PMID:11689694), (PMID:9891014)		 RGD PMID:9891014 PMID:10220385 PMID:11689694 PMID:23322205 PMID:24882211 MGI:5605128 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Hdac7 histone deacetylase 7 enables TAS
ISO
ISS
IEA		 PMID:12711221
(MGI:1889866|PMID:10640276)
GO_REF:0000024
GO_REF:0000104
GO_REF:0000116
GO_REF:0000003		 RGD
UniProt
RHEA		 PMID:10640276 PMID:12711221 GO_REF:0000003 GO_REF:0000024 GO_REF:0000104 GO_REF:0000116 MGI:1889866, RGD:8553516 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
GO_REF:0000002
(PMID:28497810)		 UniProt
GO_Central
TreeGrafter
Ensembl
InterPro
RGD		 PMID:28497810 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 NOT|enables ISO (PMID:10655483)
(PMID:11535832), (PMID:12590135)		 RGD PMID:10655483 PMID:11535832 PMID:12590135 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Mier1 MIER1 transcriptional regulator contributes_to ISO (PMID:28046085) RGD PMID:28046085 NCBI chr 5:117,876,012...117,927,592
Ensembl chr 5:117,870,382...117,927,589 		JBrowse link
G Mier2 MIER family member 2 contributes_to ISO (PMID:28046085) RGD PMID:28046085 NCBI chr 7:10,153,501...10,169,381
Ensembl chr 7:10,153,649...10,169,378 		JBrowse link
G Mier3 MIER family member 3 NOT|contributes_to ISO (PMID:28046085) RGD PMID:28046085 NCBI chr 2:43,287,546...43,316,422
Ensembl chr 2:43,287,916...43,316,136 		JBrowse link
G Mta2 metastasis associated 1 family, member 2 enables ISO (PMID:10444591) RGD PMID:10444591 NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946 		JBrowse link
G Sirt1 sirtuin 1 enables ISO (PMID:18485871) RGD PMID:18485871 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables ISS
ISO		 GO_REF:0000024
(MGI:5567889|PMID:24334550)
(PMID:17488717)		 UniProt
RGD		 PMID:17488717 PMID:24334550 GO_REF:0000024 MGI:5567889 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt4 sirtuin 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439 		JBrowse link
G Suds3 SDS3 homolog, SIN3A corepressor complex component contributes_to ISO (PMID:21239494) RGD PMID:21239494 NCBI chr12:39,477,181...39,499,633
Ensembl chr12:39,477,568...39,499,628 		JBrowse link
histone H3K deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO (PMID:20027304) RGD PMID:20027304 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
histone H3K14 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac9 histone deacetylase 9 enables ISO (MGI:5287924|PMID:21708950) RGD PMID:21708950 MGI:5287924 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
histone H3K9 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac9 histone deacetylase 9 enables ISO (MGI:5287924|PMID:21708950) RGD PMID:21708950 MGI:5287924 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
histone H4K12 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO (PMID:15469825) RGD PMID:15469825 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
histone H4K16 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac2 histone deacetylase 2 enables ISO (MGI:5619732|PMID:23516383) RGD PMID:23516383 MGI:5619732 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac9 histone deacetylase 9 enables ISO (PMID:28855441) RGD PMID:28855441 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
NAD-dependent histone deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables IDA
ISO
IBA		 (PMID:10693811)
GO_REF:0000033
(PMID:12006491), (PMID:15469825), (PMID:16079181), (PMID:16959573), (PMID:28497810)		 RGD
GO_Central		 PMID:10693811 PMID:12006491 PMID:15469825 PMID:16079181 PMID:16959573 More... GO_REF:0000033, RGD:2316170 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 NOT|enables ISO
IEA
IBA		 (PMID:24177535)
GO_REF:0000118
GO_REF:0000033
GO_REF:0000002
(PMID:11427894), (PMID:12697818)		 RGD
TreeGrafter
GO_Central
InterPro		 PMID:11427894 PMID:12697818 PMID:24177535 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt3 sirtuin 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Sirt5 sirtuin 5 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101 		JBrowse link
G Sirt6 sirtuin 6 enables ISO (PMID:24043303), (PMID:27912097) RGD PMID:24043303 PMID:27912097 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
NAD-dependent histone H3K14 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO (PMID:15469825) RGD PMID:15469825 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
NAD-dependent histone H3K18 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt6 sirtuin 6 enables ISO (PMID:27043296)
(MGI:7258357|PMID:31002797)		 RGD PMID:27043296 PMID:31002797 MGI:7258357 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Sirt7 sirtuin 7 enables ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000118
GO_REF:0000033
(MGI:5789069|PMID:27225932), (MGI:6377981|PMID:31226208), (MGI:6378020|PMID:31256246)
(PMID:22722849), (PMID:26907567), (PMID:28655758), (PMID:30420520), (PMID:30653310), (PMID:35939806)		 UniProt
TreeGrafter
GO_Central
RGD		 PMID:22722849 PMID:26907567 PMID:27225932 PMID:28655758 PMID:30420520 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:5789069 MGI:6377981 MGI:6378020 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
NAD-dependent histone H3K56 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt6 sirtuin 6 enables ISO (PMID:23911928), (PMID:26456828), (PMID:26898756), (PMID:27912097), (PMID:30374165)
(MGI:4867348|PMID:21098266), (MGI:6103696|PMID:28355567), (MGI:6757299|PMID:25915124), (MGI:7258357|PMID:31002797), (PMID:31399344)		 RGD PMID:21098266 PMID:23911928 PMID:25915124 PMID:26456828 PMID:26898756 More... MGI:4867348 MGI:6103696 MGI:6757299 MGI:7258357 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
NAD-dependent histone H3K9 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO
IEA		 (MGI:4887284|PMID:20972425)
(PMID:15469825)
GO_REF:0000107		 RGD
Ensembl		 PMID:15469825 PMID:20972425 GO_REF:0000107 MGI:4887284 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 enables ISO
IBA		 (MGI:4867348|PMID:21098266), (MGI:4881401|PMID:20141841), (MGI:6103696|PMID:28355567), (MGI:6284084|PMID:29555651), (MGI:6357632|PMID:31399344), (MGI:6757299|PMID:25915124), (MGI:7258357|PMID:31002797), (PMID:31399344)
GO_REF:0000033
(PMID:18337721), (PMID:23892288), (PMID:26456828), (PMID:29555651), (PMID:30374165), (PMID:33067423)		 RGD
GO_Central		 PMID:18337721 PMID:20141841 PMID:21098266 PMID:23892288 PMID:25915124 More... GO_REF:0000033 MGI:4867348 MGI:4881401 MGI:6103696 MGI:6284084 MGI:6357632 MGI:6757299 MGI:7258357 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
NAD-dependent histone H4K16 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO
IEA		 (PMID:15469825)
GO_REF:0000118		 RGD
TreeGrafter		 PMID:15469825 GO_REF:0000118 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables ISO
ISS
IEA		 (PMID:16648462)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:16648462 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      catalytic activity, acting on a protein 2496
        protein lysine deacetylase activity 26
          histone deacetylase activity 26
            NAD-dependent histone deacetylase activity + 6
            NAD-independent histone deacetylase activity 0
            histone H3K deacetylase activity + 4
            histone H4K deacetylase activity + 4
Path 2
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      hydrolase activity 2630
        hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 135
          hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 77
            histone deacetylase activity 26
              NAD-dependent histone deacetylase activity + 6
              NAD-independent histone deacetylase activity 0
              histone H3K deacetylase activity + 4
              histone H4K deacetylase activity + 4
paths to the root