ONTOLOGY REPORT - ANNOTATIONS
Term: histone deacetylase activity
Accession: GO:0004407
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Definition: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
Synonyms: xref: EC:3.5.1.98; MetaCyc:3.5.1.98-RXN; RHEA:58196; Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones"; reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin"; reactome:R-HSA-2545253 "Deacetylation of cohesin"; reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone"; reactome:R-HSA-3782637 "HDAC8 deacetylates histones"; reactome:R-HSA-3782655 "HDAC10 deacetylates histone"; reactome:R-HSA-427514 "eNoSC deacetylates histone H3"; reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3"; reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53"
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Atxn3
ataxin 3
contributes_to
IDA
RGD
PMID:17079677
RGD:5688291
NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
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ENSRNOG00000069033
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
Ensembl chr 7:78,933,181...78,934,754
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Hdac1
histone deacetylase 1
enables
ISS IEA IBA ISO
GO_REF:0000024 GO_REF:0000118 GO_REF:0000033 (PMID:12590135), (PMID:16762839), (PMID:17996965), (PMID:19182791), (PMID:28497810) GO_REF:0000002 (MGI:3687778|PMID:10615135), (MGI:5288521|PMID:21960634), (MGI:6867113|PMID:30279482)
UniProt TreeGrafter GO_Central RGD InterPro
PMID:10615135 PMID:12590135 PMID:16762839 PMID:17996965 PMID:19182791 PMID:21960634 PMID:28497810 PMID:30279482 More...
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:3687778 MGI:5288521 MGI:6867113
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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Hdac10
histone deacetylase 10
enables
ISO IEA
(PMID:11861901) GO_REF:0000107 (PMID:11739383)
RGD Ensembl
PMID:11739383 PMID:11861901
GO_REF:0000107
NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228
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Hdac11
histone deacetylase 11
enables
ISO IBA
(PMID:11948178) GO_REF:0000033
RGD GO_Central
PMID:11948178
GO_REF:0000033
NCBI chr 4:123,645,873...123,667,407
Ensembl chr 4:123,650,157...123,667,405
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Hdac1l
histone deacetylase 1-like
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593
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Hdac2
histone deacetylase 2
enables
ISO IBA
(PMID:16642021), (PMID:28497810) MGI:1916782 (MGI:3811960|PMID:18754010), (MGI:5567917|PMID:15226430), (MGI:6867113|PMID:30279482), (PMID:12975471) GO_REF:0000033
RGD GO_Central
PMID:12975471 PMID:15226430 PMID:16642021 PMID:18754010 PMID:28497810 PMID:30279482 More...
GO_REF:0000033 MGI:3811960 MGI:5567917 MGI:6867113
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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Hdac3
histone deacetylase 3
contributes_to enables
IDA ISO IEA
(MGI:6867113|PMID:30279482), (PMID:15832170), (PMID:17464331) GO_REF:0000118 GO_REF:0000002 (PMID:16924111), (PMID:18326024), (PMID:28497810) GO_REF:0000116 GO_REF:0000003
RGD TreeGrafter InterPro RHEA UniProt
PMID:15832170 PMID:16924111 PMID:17464331 PMID:18326024 PMID:28497810 PMID:30279482 PMID:17079677 More...
GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000118 MGI:6867113 , RGD:5688291
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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Hdac4
histone deacetylase 4
enables
IEA ISO
GO_REF:0000104 (PMID:10220385), (PMID:10869435), (PMID:12590135)
UniProt RGD
PMID:10220385 PMID:10869435 PMID:12590135
GO_REF:0000104
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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Hdac5
histone deacetylase 5
enables
ISO
(PMID:10869435) (MGI:1889866|PMID:10640276)
RGD
PMID:10640276 PMID:10869435
MGI:1889866
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
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Hdac6
histone deacetylase 6
enables
ISO
(PMID:10220385), (PMID:23322205) (MGI:5605128|PMID:24882211), (PMID:11689694), (PMID:9891014)
RGD
PMID:9891014 PMID:10220385 PMID:11689694 PMID:23322205 PMID:24882211
MGI:5605128
NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441
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Hdac7
histone deacetylase 7
enables
TAS ISO ISS IEA
PMID:12711221 (MGI:1889866|PMID:10640276) GO_REF:0000024 GO_REF:0000104 GO_REF:0000116 GO_REF:0000003
RGD UniProt RHEA
PMID:10640276 PMID:12711221
GO_REF:0000003 GO_REF:0000024 GO_REF:0000104 GO_REF:0000116 MGI:1889866 , RGD:8553516
NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
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Hdac8
histone deacetylase 8
enables
ISS IBA IEA ISO
GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 GO_REF:0000107 GO_REF:0000002 (PMID:28497810)
UniProt GO_Central TreeGrafter Ensembl InterPro RGD
PMID:28497810
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
NCBI chr X:67,385,288...67,593,014
Ensembl chr X:67,385,289...67,592,923
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Hdac9
histone deacetylase 9
NOT|enables
ISO
(PMID:10655483) (PMID:11535832), (PMID:12590135)
RGD
PMID:10655483 PMID:11535832 PMID:12590135
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
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Mier1
MIER1 transcriptional regulator
contributes_to
ISO
(PMID:28046085)
RGD
PMID:28046085
NCBI chr 5:117,876,012...117,927,592
Ensembl chr 5:117,870,382...117,927,589
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Mier2
MIER family member 2
contributes_to
ISO
(PMID:28046085)
RGD
PMID:28046085
NCBI chr 7:10,153,501...10,169,381
Ensembl chr 7:10,153,649...10,169,378
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Mier3
MIER family member 3
NOT|contributes_to
ISO
(PMID:28046085)
RGD
PMID:28046085
NCBI chr 2:43,287,546...43,316,422
Ensembl chr 2:43,287,916...43,316,136
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Mta2
metastasis associated 1 family, member 2
enables
ISO
(PMID:10444591)
RGD
PMID:10444591
NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946
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Sirt1
sirtuin 1
enables
ISO
(PMID:18485871)
RGD
PMID:18485871
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Sirt2
sirtuin 2
enables
ISS ISO
GO_REF:0000024 (MGI:5567889|PMID:24334550) (PMID:17488717)
UniProt RGD
PMID:17488717 PMID:24334550
GO_REF:0000024 MGI:5567889
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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Sirt4
sirtuin 4
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439
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Suds3
SDS3 homolog, SIN3A corepressor complex component
contributes_to
ISO
(PMID:21239494)
RGD
PMID:21239494
NCBI chr12:39,477,181...39,499,633
Ensembl chr12:39,477,568...39,499,628
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Sirt1
sirtuin 1
enables
ISO
(PMID:20027304)
RGD
PMID:20027304
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Hdac9
histone deacetylase 9
enables
ISO
(MGI:5287924|PMID:21708950)
RGD
PMID:21708950
MGI:5287924
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
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Hdac9
histone deacetylase 9
enables
ISO
(MGI:5287924|PMID:21708950)
RGD
PMID:21708950
MGI:5287924
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
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Sirt1
sirtuin 1
enables
ISO
(PMID:15469825)
RGD
PMID:15469825
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Hdac2
histone deacetylase 2
enables
ISO
(MGI:5619732|PMID:23516383)
RGD
PMID:23516383
MGI:5619732
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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Hdac9
histone deacetylase 9
enables
ISO
(PMID:28855441)
RGD
PMID:28855441
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
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Sirt1
sirtuin 1
enables
IDA ISO IBA
(PMID:10693811) GO_REF:0000033 (PMID:12006491), (PMID:15469825), (PMID:16079181), (PMID:16959573), (PMID:28497810)
RGD GO_Central
PMID:10693811 PMID:12006491 PMID:15469825 PMID:16079181 PMID:16959573 PMID:28497810 PMID:19356683 More...
GO_REF:0000033, RGD:2316170
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Sirt2
sirtuin 2
NOT|enables
ISO IEA IBA
(PMID:24177535) GO_REF:0000118 GO_REF:0000033 GO_REF:0000002 (PMID:11427894), (PMID:12697818)
RGD TreeGrafter GO_Central InterPro
PMID:11427894 PMID:12697818 PMID:24177535
GO_REF:0000002 GO_REF:0000033 GO_REF:0000118
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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Sirt3
sirtuin 3
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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Sirt5
sirtuin 5
enables
IEA
GO_REF:0000118
TreeGrafter
GO_REF:0000118
NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101
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Sirt6
sirtuin 6
enables
ISO
(PMID:24043303), (PMID:27912097)
RGD
PMID:24043303 PMID:27912097
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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Sirt1
sirtuin 1
enables
ISO
(PMID:15469825)
RGD
PMID:15469825
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Sirt6
sirtuin 6
enables
ISO
(PMID:27043296) (MGI:7258357|PMID:31002797)
RGD
PMID:27043296 PMID:31002797
MGI:7258357
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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Sirt7
sirtuin 7
enables
ISS IEA IBA ISO
GO_REF:0000024 GO_REF:0000118 GO_REF:0000033 (MGI:5789069|PMID:27225932), (MGI:6377981|PMID:31226208), (MGI:6378020|PMID:31256246) (PMID:22722849), (PMID:26907567), (PMID:28655758), (PMID:30420520), (PMID:30653310), (PMID:35939806)
UniProt TreeGrafter GO_Central RGD
PMID:22722849 PMID:26907567 PMID:27225932 PMID:28655758 PMID:30420520 PMID:30653310 PMID:31226208 PMID:31256246 PMID:35939806 More...
GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:5789069 MGI:6377981 MGI:6378020
NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172
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Sirt6
sirtuin 6
enables
ISO
(PMID:23911928), (PMID:26456828), (PMID:26898756), (PMID:27912097), (PMID:30374165) (MGI:4867348|PMID:21098266), (MGI:6103696|PMID:28355567), (MGI:6757299|PMID:25915124), (MGI:7258357|PMID:31002797), (PMID:31399344)
RGD
PMID:21098266 PMID:23911928 PMID:25915124 PMID:26456828 PMID:26898756 PMID:27912097 PMID:28355567 PMID:30374165 PMID:31002797 PMID:31399344 More...
MGI:4867348 MGI:6103696 MGI:6757299 MGI:7258357
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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Sirt1
sirtuin 1
enables
ISO IEA
(MGI:4887284|PMID:20972425) (PMID:15469825) GO_REF:0000107
RGD Ensembl
PMID:15469825 PMID:20972425
GO_REF:0000107 MGI:4887284
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Sirt6
sirtuin 6
enables
ISO IBA
(MGI:4867348|PMID:21098266), (MGI:4881401|PMID:20141841), (MGI:6103696|PMID:28355567), (MGI:6284084|PMID:29555651), (MGI:6357632|PMID:31399344), (MGI:6757299|PMID:25915124), (MGI:7258357|PMID:31002797), (PMID:31399344) GO_REF:0000033 (PMID:18337721), (PMID:23892288), (PMID:26456828), (PMID:29555651), (PMID:30374165), (PMID:33067423)
RGD GO_Central
PMID:18337721 PMID:20141841 PMID:21098266 PMID:23892288 PMID:25915124 PMID:26456828 PMID:28355567 PMID:29555651 PMID:30374165 PMID:31002797 PMID:31399344 PMID:33067423 More...
GO_REF:0000033 MGI:4867348 MGI:4881401 MGI:6103696 MGI:6284084 MGI:6357632 MGI:6757299 MGI:7258357
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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Sirt1
sirtuin 1
enables
ISO IEA
(PMID:15469825) GO_REF:0000118
RGD TreeGrafter
PMID:15469825
GO_REF:0000118
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Sirt2
sirtuin 2
enables
ISO ISS IEA
(PMID:16648462) GO_REF:0000024 GO_REF:0000107
RGD UniProt Ensembl
PMID:16648462
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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