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ONTOLOGY REPORT - ANNOTATIONS

Term:store-operated calcium channel activity
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Accession:GO:0015279 term browser browse the term
Definition:A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
Synonyms:xref: reactome:R-HSA-434798 "CRAC translocates calcium from the extracellular region to the cytosol"


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store-operated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Orai1 ORAI calcium release-activated calcium modulator 1 enables IMP
IEA
ISS
IBA
ISO		 GO_REF:0000107
GO_REF:0000024
GO_REF:0000033
(PMID:16645049), (PMID:16733527), (PMID:16766533), (PMID:16807233), (PMID:16921383), (PMID:17442569), (PMID:19182790), (PMID:23307288), (PMID:28219928), (PMID:32415068)
(PMID:26221052)
(PMID:33941685)
(PMID:31664108)		 Ensembl
UniProt
GO_Central
RGD		 PMID:16645049 PMID:16733527 PMID:16766533 PMID:16807233 PMID:16921383 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:7175077 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405 		JBrowse link
G Orai2 ORAI calcium release-activated calcium modulator 2 enables IBA
ISO		 GO_REF:0000033
(PMID:17442569), (PMID:19182790), (PMID:32415068)		 GO_Central
RGD		 PMID:17442569 PMID:19182790 PMID:32415068 GO_REF:0000033 NCBI chr12:20,500,308...20,520,428
Ensembl chr12:20,497,317...20,520,428 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 enables IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:17442569), (PMID:19182790), (PMID:32415068)		 GO_Central
Ensembl
RGD		 PMID:17442569 PMID:19182790 PMID:32415068 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052 		JBrowse link
G Stim1 stromal interaction molecule 1 IMP RGD PMID:21389210 RGD:7175077 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363 		JBrowse link
G Stim2 stromal interaction molecule 2 enables ISO (PMID:16860747) RGD PMID:16860747 NCBI chr14:56,878,428...57,004,405
Ensembl chr14:56,878,645...57,004,179 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 enables IBA
ISO		 GO_REF:0000033
MGI:3764882 (PMID:17956991)		 GO_Central
RGD		 PMID:17956991 GO_REF:0000033 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 enables
NOT|enables		 IBA
ISO		 GO_REF:0000033
(PMID:10051594)
(PMID:10998353)		 GO_Central
RGD		 PMID:10051594 PMID:10998353 GO_REF:0000033 NCBI chr 1:156,460,009...156,473,039
Ensembl chr 1:156,440,305...156,473,073 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855 		JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 enables ISO
IEA
IBA		 (PMID:16254212)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:16254212 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:107,946,163...108,230,991
Ensembl chr  X:107,939,131...108,230,991 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 enables IBA
ISO		 GO_REF:0000033
(PMID:8646775)		 GO_Central
RGD		 PMID:8646775 GO_REF:0000033 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:7,708,911...7,833,435
Ensembl chr17:7,709,583...7,833,435 		JBrowse link
G Xndc1 Xrcc1 N-terminal domain containing 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:156,440,284...156,460,609 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        monoatomic ion transmembrane transporter activity 759
          monoatomic ion channel activity 448
            monoatomic cation channel activity 337
              calcium channel activity 126
                store-operated calcium channel activity 13
Path 2
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        monoatomic ion transmembrane transporter activity 759
          monoatomic cation transmembrane transporter activity 637
            metal ion transmembrane transporter activity 452
              calcium ion transmembrane transporter activity 147
                calcium channel activity 126
                  store-operated calcium channel activity 13
paths to the root