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ONTOLOGY REPORT - ANNOTATIONS

Term:COP9 signalosome
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Accession:GO:0008180 term browser browse the term
Definition:A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
Synonyms:exact_synonym: CSN
 narrow_synonym: COP9 complex
 broad_synonym: signalosome


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COP9 signalosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMOT angiomotin located_in
part_of		 ISO
IEA		 (PMID:18850735) UniProt
Ensembl		 PMID:18850735 GO_REF:0000107 NCBI chr  X:85,742,610...85,807,557
Ensembl chr  X:85,745,207...85,807,353 		JBrowse link
G AMOTL1 angiomotin like 1 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr21:6,109,600...6,280,025
Ensembl chr21:6,109,683...6,256,060 		JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha located_in ISO (PMID:18850735) UniProt PMID:18850735 NCBI chr 7:45,118,188...45,127,048
Ensembl chr 7:45,117,657...45,127,048 		JBrowse link
G BASP1 brain abundant membrane attached signal protein 1 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr 4:86,360,641...86,417,408
Ensembl chr 4:86,361,608...86,382,715 		JBrowse link
G COPS2 COP9 signalosome subunit 2 located_in
part_of		 ISO
IEA		 (PMID:25043011) ComplexPortal
Ensembl
TreeGrafter		 PMID:25043011 GO_REF:0000107 GO_REF:0000118 NCBI chr30:15,332,411...15,365,528
Ensembl chr30:15,334,096...15,365,443 		JBrowse link
G COPS3 COP9 signalosome subunit 3 located_in
part_of		 ISO
IEA		 (PMID:25043011) ComplexPortal
Ensembl
UniProt
TreeGrafter		 PMID:25043011 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:42,143,397...42,169,509
Ensembl chr 5:42,143,474...42,169,517 		JBrowse link
G COPS4 COP9 signalosome subunit 4 located_in
part_of		 ISO
IEA		 (PMID:25043011) ComplexPortal
TreeGrafter		 PMID:25043011 GO_REF:0000118 NCBI chr32:6,957,189...6,997,573
Ensembl chr32:6,957,390...6,997,180 		JBrowse link
G COPS5 COP9 signalosome subunit 5 located_in
part_of		 ISO
IEA		 (PMID:25043011) ComplexPortal
UniProt
Ensembl
TreeGrafter		 PMID:25043011 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr29:16,562,234...16,579,082
Ensembl chr29:16,562,234...16,578,847 		JBrowse link
G COPS6 COP9 signalosome subunit 6 located_in
part_of		 ISO
IEA		 (PMID:25043011) ComplexPortal
UniProt
InterPro
Ensembl
TreeGrafter		 PMID:25043011 GO_REF:0000002 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:9,500,715...9,503,481
Ensembl chr 6:9,500,724...9,503,328 		JBrowse link
G COPS7A COP9 signalosome subunit 7A located_in
part_of		 ISO
IEA		 (PMID:25043011) ComplexPortal
InterPro
Ensembl
TreeGrafter		 PMID:25043011 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr27:38,301,608...38,313,801
Ensembl chr27:38,307,316...38,313,166 		JBrowse link
G COPS7B COP9 signalosome subunit 7B part_of IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr25:43,637,170...43,663,218
Ensembl chr25:43,637,335...43,661,654 		JBrowse link
G COPS8 COP9 signalosome subunit 8 located_in
part_of		 ISO
IEA		 (PMID:25043011) ComplexPortal
InterPro
UniProt
TreeGrafter		 PMID:25043011 GO_REF:0000002 GO_REF:0000043 GO_REF:0000117 GO_REF:0000118 NCBI chr25:47,783,241...47,796,806 JBrowse link
G COPS9 COP9 signalosome subunit 9 part_of
located_in		 ISO (PMID:26456823)
(PMID:23776465)		 UniProt PMID:23776465 PMID:26456823
G DCAF1 DDB1 and CUL4 associated factor 1 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr20:38,109,974...38,187,621
Ensembl chr20:38,125,078...38,187,107 		JBrowse link
G DOCK7 dedicator of cytokinesis 7 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr 5:47,435,209...47,653,312
Ensembl chr 5:47,462,224...47,653,163 		JBrowse link
G DYNLL1 dynein light chain LC8-type 1 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr26:16,369,878...16,402,302
Ensembl chr26:16,398,886...16,402,021
Ensembl chr26:16,398,886...16,402,021 		JBrowse link
G EPB41L2 erythrocyte membrane protein band 4.1 like 2 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr 1:69,120,583...69,274,433
Ensembl chr 1:69,121,139...69,286,381 		JBrowse link
G FLOT1 flotillin 1 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr12:517,941...528,677
Ensembl chr12:516,032...528,637 		JBrowse link
G GPS1 G protein pathway suppressor 1 located_in
part_of		 ISO
IEA		 (PMID:25043011) ComplexPortal
Ensembl
TreeGrafter		 PMID:25043011 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:261,835...265,757
Ensembl chr 9:262,047...265,706 		JBrowse link
G GRAP GRB2 related adaptor protein part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 5:41,014,193...41,038,965 JBrowse link
G GRB2 growth factor receptor bound protein 2 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:5,108,128...5,182,091
Ensembl chr 9:5,117,164...5,180,296 		JBrowse link
G HSP70 heat shock protein 70 located_in ISO (PMID:18850735) UniProt PMID:18850735 NCBI chr12:1,285,282...1,287,670 JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 located_in
part_of		 ISO
IEA		 (PMID:18850735) UniProt
Ensembl		 PMID:18850735 GO_REF:0000107 NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G LAT linker for activation of T cells part_of IEA Ensembl GO_REF:0000107 NCBI chr 6:18,458,985...18,462,463
Ensembl chr 6:18,459,061...18,462,694 		JBrowse link
G LOC100687242 heat shock protein HSP 90-beta-like part_of IEA Ensembl GO_REF:0000107 NCBI chr11:7,591,965...7,594,265 JBrowse link
G LOC474850 heat shock 70 kDa protein 1-like part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr12:1,281,164...1,285,010
Ensembl chr12:1,281,472...1,285,440 		JBrowse link
G MYH9 myosin heavy chain 9 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr10:28,063,626...28,122,953
Ensembl chr10:28,063,624...28,122,953 		JBrowse link
G NCKIPSD NCK interacting protein with SH3 domain part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr20:40,443,245...40,449,859
Ensembl chr20:40,442,386...40,449,542 		JBrowse link
G PLCG1 phospholipase C gamma 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
G SLA Src like adaptor part_of IEA TreeGrafter GO_REF:0000118 NCBI chr13:29,503,304...29,590,679
Ensembl chr13:29,504,867...29,569,773 		JBrowse link
G SLA2 Src like adaptor 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr24:25,396,187...25,426,789
Ensembl chr24:25,396,900...25,422,467 		JBrowse link
G TESPA1 thymocyte expressed, positive selection associated 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr27:424,836...460,114
Ensembl chr27:424,715...460,097 		JBrowse link
G THAP9 THAP domain containing 9 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr32:6,852,057...6,875,660
Ensembl chr32:6,852,116...6,870,696 		JBrowse link
G THEMIS thymocyte selection associated part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:66,363,172...66,540,272
Ensembl chr 1:66,363,125...66,540,327 		JBrowse link
G TMOD1 tropomodulin 1 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr11:54,853,205...54,914,236
Ensembl chr11:54,853,204...54,912,773 		JBrowse link
G WDR6 WD repeat domain 6 part_of
located_in		 IEA
ISO		 (PMID:18850735) Ensembl
UniProt		 PMID:18850735 GO_REF:0000107 NCBI chr20:40,148,262...40,157,770
Ensembl chr20:40,148,928...40,157,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18906
    protein-containing complex 6503
      nuclear protein-containing complex 1341
        COP9 signalosome 37
Path 2
Term Annotations click to browse term
  cellular_component 18906
    cellular anatomical entity 18654
      organelle 13269
        membrane-bounded organelle 12054
          intracellular membrane-bounded organelle 11490
            nucleus 7273
              nuclear protein-containing complex 1341
                COP9 signalosome 37
paths to the root