COPS3 (COP9 signalosome subunit 3)

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Gene: COPS3 (COP9 signalosome subunit 3) Canis lupus familiaris

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Symbol:

COPS3

Name:

COP9 signalosome subunit 3

RGD ID:

12098446

Description:

INVOLVED IN in utero embryonic development (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Birt-Hogg-Dube syndrome (ortholog); common variable immunodeficiency 2 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

COP9 constitutive photomorphogenic homolog subunit 3; COP9 signalosome complex subunit 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	COPS3 (COP9 signalosome subunit 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cops3 (COP9 signalosome subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cops3 (COP9 signalosome subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cops3 (COP9 signalosome subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	COPS3 (COP9 signalosome subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cops3 (COP9 signalosome subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	COPS3 (COP9 signalosome subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	COPS3 (COP9 signalosome subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cops3 (COP9 signalosome subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	42,143,397 - 42,169,509 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	42,143,474 - 42,169,517 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	42,283,352 - 42,309,239 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	42,251,785 - 42,277,904 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	42,251,786 - 42,280,691 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	42,218,758 - 42,244,870 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	42,166,098 - 42,192,196 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	42,358,201 - 42,384,316 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Birt-Hogg-Dube syndrome (ISO)

common variable immunodeficiency 2 (ISO)

Hepatomegaly (ISO)

Joubert syndrome 1 (ISO)

Potocki-Lupski syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

in utero embryonic development (IEA,ISO)

protein deneddylation (IEA)

regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (IEA)

Cellular Component

COP9 signalosome (IEA)

cytoplasm (IEA,ISO)

cytosol (IEA)

nucleoplasm (IEA)

nucleus (IEA,ISO)

perinuclear region of cytoplasm (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

COPS3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	42,143,397 - 42,169,509 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	42,143,474 - 42,169,517 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	42,283,352 - 42,309,239 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	42,251,785 - 42,277,904 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	42,251,786 - 42,280,691 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	42,218,758 - 42,244,870 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	42,166,098 - 42,192,196 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	42,358,201 - 42,384,316 (+)	NCBI		UU_Cfam_GSD_1.0

COPS3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	17,246,616 - 17,281,246 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	17,246,616 - 17,281,273 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	17,149,930 - 17,184,560 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	17,090,864 - 17,125,316 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	17,090,865 - 17,125,316	NCBI
Celera	17	18,089,725 - 18,124,196 (-)	NCBI		Celera
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	16,902,830 - 16,937,477 (-)	NCBI		HuRef
CHM1_1	17	17,159,638 - 17,194,346 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	17,192,637 - 17,227,324 (-)	NCBI		T2T-CHM13v2.0

Cops3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	59,708,621 - 59,739,080 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	59,708,621 - 59,730,664 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	59,817,795 - 59,848,245 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	59,817,795 - 59,839,838 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	59,631,306 - 59,653,269 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	60,354,384 - 60,376,347 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	59,633,999 - 59,655,962 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	37.8	NCBI

Cops3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	45,117,664 - 45,151,868 (-)	NCBI		GRCr8
mRatBN7.2	10	44,618,115 - 44,652,807 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	44,618,115 - 44,641,597 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	49,318,474 - 49,341,861 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	48,808,835 - 48,832,218 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	44,312,440 - 44,335,827 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	46,182,680 - 46,206,083 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	46,182,687 - 46,206,135 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	45,938,610 - 45,962,047 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,139,837 - 46,163,246 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	46,153,461 - 46,176,869 (-)	NCBI
Celera	10	43,879,656 - 43,903,024 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

Cops3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955577	638,749 - 664,390 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955577	639,616 - 664,390 (+)	NCBI	ChiLan1.0	ChiLan1.0

COPS3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	51,764,384 - 51,799,287 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	56,476,072 - 56,510,971 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	34,013,180 - 34,047,546 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	38,944,506 - 38,978,514 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	38,944,618 - 38,978,235 (+)	Ensembl	panpan1.1		panPan2

Cops3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	61,936,099 - 61,961,655 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936741	905,252 - 931,408 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936741	905,593 - 931,148 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COPS3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	60,994,310 - 61,024,846 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	61,000,562 - 61,023,920 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	63,034,590 - 63,057,951 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COPS3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	16,280,490 - 16,331,538 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666059	4,596,000 - 4,632,806 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cops3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624849	4,124,586 - 4,150,933 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624849	4,125,188 - 4,150,933 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in COPS3
201 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022418660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022418661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038475937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038475938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038537127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038537128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038601256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038601257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038665820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038665821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_859708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000029331 ⟹ ENSCAFP00000027275

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	5	42,143,474 - 42,169,437 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000061725 ⟹ ENSCAFP00000043260

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	5	42,143,474 - 42,169,517 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000063211 ⟹ ENSCAFP00000045503

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	5	42,145,665 - 42,169,437 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845043215 ⟹ ENSCAFP00845033879

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	5	42,251,786 - 42,280,691 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845043331 ⟹ ENSCAFP00845033957

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	5	42,251,786 - 42,280,691 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845043434 ⟹ ENSCAFP00845034029

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	5	42,254,869 - 42,280,691 (+)	Ensembl

RefSeq Acc Id:

XM_022418661 ⟹ XP_022274369

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	42,149,620 - 42,169,509 (+)	NCBI
Dog10K_Boxer_Tasha	5	42,289,195 - 42,309,239 (+)	NCBI

Sequence:

show sequence

CTCTAGTTGCTGGGCTTTGCCATCAGCTGACAAACGCGCTTGTGGAAAGGAAACAGTGACAACC
TAAGATCCAATGTGCTGCCATCTTTGAGAACTTATCTGAAAGAGATGTCATTTCTGACAGCCCC
TGCGAGGAATCAGCATCCTTAAGCAAGCCATAGACAAGATGCAGATGAATACAAACCAGCTGAC
CTCAATACATGCCGATCTCTGCCAGCTTTGTTTGCTGGCAAAATGCTTTAAGCCTGCCCTCCCG
TATCTTGATGTAGACATGATGGATATCTGTAAAGAGAATGGAGCCTATGATGCAAAGCACTTTT
TATGTTACTATTATTATGGAGGGATGATCTATACCGGGCTGAAGAACTTTGAAAGAGCGCTGTA
CTTTTATGAACAGGCTATAACTACTCCTGCCATGGCGGTCAGTCACATCATGTTGGAATCATAT
AAAAAGTATATTCTAGTTTCTTTGATATTACTTGGAAAAGTACAACAGCTACCGAAATACACGT
CTCAAATTGTGGGTAGATTCATTAAGCCTCTTAGCAACGCGTACCATGAGTTAGCACAAGTTTA
TTCAACCAATAATCCCTCAGAACTCCGCAACCTGGTCAACAAGCACAGTGAAACTTTTACTCGC
GATAACAACATGGGGCTGGTGAAGCAATGCCTGTCTTCTCTTTATAAGAAGAATATTCAGAGGC
TAACCAAGACCTTTTTAACATTATCGTTACAAGATATGGCAAGTCGTGTGCAGTTATCTGGACC
TCAGGAGGCAGAGAAATATGTCCTACACATGATAGAGGATGGTGAAATTTTTGCAAGTATTAAT
CAGAAGGATGGAATGGTCAGTTTCCATGATAACCCTGAAAAATATAATAACCCAGCCATGCTTC
ATAACATCGATCAAGAGATGCTGAAGTGCATAGAGCTGGATGAGCGACTGAAGGCCATGGACCA
GGAGATCACAGTGAACCCCCAGTTCGTACAGAAGAGCATGGGATCACAAGAAGATGATTCTGGA
AACAAACCATCTAGTTACTCTTGAAACTAACATCCATCCTGAGTTAGATGGAATTTATCACCTT
GGCCAGTGGCAAGTGTTAGGAGGGCAGCAGGGAGGACCAAGCCTGTGTGACCTGGACATTAAGA
AATTACATTTTGTTTTGACATCTTCAGTCCTATGTGCTTTAAGAAAACCATTCTCTCTGCAAAG
AAAGGAAAAAAAATTCAAACTTTAAAGTCTGTTGTGGATTTATTTATCCTGAGATTAATGTTGT
TGCATTAAATCTACATTTTTGTTTTAAATTA

hide sequence

RefSeq Acc Id:

XM_038475937 ⟹ XP_038331865

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	42,218,758 - 42,244,870 (+)	NCBI

RefSeq Acc Id:

XM_038475938 ⟹ XP_038331866

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	5	42,224,827 - 42,244,870 (+)	NCBI

RefSeq Acc Id:

XM_038537127 ⟹ XP_038393055

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	42,358,201 - 42,384,316 (+)	NCBI

RefSeq Acc Id:

XM_038537128 ⟹ XP_038393056

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	5	42,364,272 - 42,384,316 (+)	NCBI

RefSeq Acc Id:

XM_038601256 ⟹ XP_038457184

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	42,166,098 - 42,192,196 (+)	NCBI

RefSeq Acc Id:

XM_038601257 ⟹ XP_038457185

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	5	42,172,165 - 42,192,196 (+)	NCBI

RefSeq Acc Id:

XM_038665820 ⟹ XP_038521748

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	42,251,785 - 42,277,904 (+)	NCBI

RefSeq Acc Id:

XM_038665821 ⟹ XP_038521749

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	5	42,257,864 - 42,277,904 (+)	NCBI

RefSeq Acc Id:

XM_859708 ⟹ XP_864801

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	42,143,397 - 42,169,509 (+)	NCBI
Dog10K_Boxer_Tasha	5	42,283,352 - 42,309,239 (+)	NCBI

Sequence:

show sequence

GAAGTGACGTCGGGCCGCTGTTGAGGCCCTGTGGAGGATAGCCGCGGCCCCTCCTCCCAGAGCA
GCCGCCTTTTCCCGCGTGAGCTGCCTCTGCTGCTTGGGCCGCCGCGGGGAAATATGGCGTCTGC
CCTGGAGCAATTCGTGAACAGTGTCCGACAGCTCTCGGCTCAAGGGCAAATGACTCAGCTTTGT
GAACTGATCAACAAGAGTGGGGAACTCCTTGCAAAGAACTTATCCCATCTGGACACCGTGCTGG
GGGCTCTGGATGTACAAGAGCATTCCTTAGGCGTCCTTGCTGTTTTGTTTGTGAAGTTTTCCAT
GCCTAGCGTTCCTGACTTCGAAACATTATTCTCACAGGTTCAGCTTTTCATCAGCACTTGTAAT
GGGGAGCACATCCGATACGCAACAGACACTTTTGCTGGGCTTTGCCATCAGCTGACAAACGCGC
TTGTGGAAAGGAAACAGCCCCTGCGAGGAATCAGCATCCTTAAGCAAGCCATAGACAAGATGCA
GATGAATACAAACCAGCTGACCTCAATACATGCCGATCTCTGCCAGCTTTGTTTGCTGGCAAAA
TGCTTTAAGCCTGCCCTCCCGTATCTTGATGTAGACATGATGGATATCTGTAAAGAGAATGGAG
CCTATGATGCAAAGCACTTTTTATGTTACTATTATTATGGAGGGATGATCTATACCGGGCTGAA
GAACTTTGAAAGAGCGCTGTACTTTTATGAACAGGCTATAACTACTCCTGCCATGGCGGTCAGT
CACATCATGTTGGAATCATATAAAAAGTATATTCTAGTTTCTTTGATATTACTTGGAAAAGTAC
AACAGCTACCGAAATACACGTCTCAAATTGTGGGTAGATTCATTAAGCCTCTTAGCAACGCGTA
CCATGAGTTAGCACAAGTTTATTCAACCAATAATCCCTCAGAACTCCGCAACCTGGTCAACAAG
CACAGTGAAACTTTTACTCGCGATAACAACATGGGGCTGGTGAAGCAATGCCTGTCTTCTCTTT
ATAAGAAGAATATTCAGAGGCTAACCAAGACCTTTTTAACATTATCGTTACAAGATATGGCAAG
TCGTGTGCAGTTATCTGGACCTCAGGAGGCAGAGAAATATGTCCTACACATGATAGAGGATGGT
GAAATTTTTGCAAGTATTAATCAGAAGGATGGAATGGTCAGTTTCCATGATAACCCTGAAAAAT
ATAATAACCCAGCCATGCTTCATAACATCGATCAAGAGATGCTGAAGTGCATAGAGCTGGATGA
GCGACTGAAGGCCATGGACCAGGAGATCACAGTGAACCCCCAGTTCGTACAGAAGAGCATGGGA
TCACAAGAAGATGATTCTGGAAACAAACCATCTAGTTACTCTTGAAACTAACATCCATCCTGAG
TTAGATGGAATTTATCACCTTGGCCAGTGGCAAGTGTTAGGAGGGCAGCAGGGAGGACCAAGCC
TGTGTGACCTGGACATTAAGAAATTACATTTTGTTTTGACATCTTCAGTCCTATGTGCTTTAAG
AAAACCATTCTCTCTGCAAAGAAAGGAAAAAAAATTCAAACTTTAAAGTCTGTTGTGGATTTAT
TTATCCTGAGATTAATGTTGTTGCATTAAATCTACATTTTTGTTTTAAATTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_022274369	(Get FASTA)	NCBI Sequence Viewer
	XP_038331865	(Get FASTA)	NCBI Sequence Viewer
	XP_038331866	(Get FASTA)	NCBI Sequence Viewer
	XP_038393055	(Get FASTA)	NCBI Sequence Viewer
	XP_038393056	(Get FASTA)	NCBI Sequence Viewer
	XP_038457184	(Get FASTA)	NCBI Sequence Viewer
	XP_038457185	(Get FASTA)	NCBI Sequence Viewer
	XP_038521748	(Get FASTA)	NCBI Sequence Viewer
	XP_038521749	(Get FASTA)	NCBI Sequence Viewer
	XP_864801	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000027275.3
	ENSCAFP00000043260.1
	ENSCAFP00000045503.1
	ENSCAFP00030003175.1
	ENSCAFP00030003200.1
	ENSCAFP00030003240.1
	ENSCAFP00040006124.1
	ENSCAFP00040006136.1
	ENSCAFP00040006155.1
	ENSCAFP00845033879
	ENSCAFP00845033879.1
	ENSCAFP00845033957.1
	ENSCAFP00845034029.1

RefSeq Acc Id:	XP_864801 ⟸ XM_859708
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0M0T8 (UniProtKB/TrEMBL), A0A8C0L8V6 (UniProtKB/TrEMBL), A0A8I3PRS1 (UniProtKB/TrEMBL), A0A8C0LXI9 (UniProtKB/TrEMBL), A0A8I3PQT2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFV KFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGISILKQAI DKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIY TGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPL SNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQ DMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCI ELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS hide sequence

RefSeq Acc Id:

XP_022274369 ⟸ XM_022418661

- Peptide Label:

isoform X2

- Sequence:

show sequence

MQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTG
LKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSN
AYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDM
ASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIEL
DERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS

hide sequence

Ensembl Acc Id:

ENSCAFP00000027275 ⟸ ENSCAFT00000029331

Ensembl Acc Id:

ENSCAFP00000045503 ⟸ ENSCAFT00000063211

Ensembl Acc Id:

ENSCAFP00000043260 ⟸ ENSCAFT00000061725

RefSeq Acc Id:	XP_038331865 ⟸ XM_038475937
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038331866 ⟸ XM_038475938
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038457184 ⟸ XM_038601256
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038457185 ⟸ XM_038601257
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038521748 ⟸ XM_038665820
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0M0T8 (UniProtKB/TrEMBL), A0A8C0L8V6 (UniProtKB/TrEMBL), A0A8I3PRS1 (UniProtKB/TrEMBL), A0A8C0LXI9 (UniProtKB/TrEMBL), A0A8I3PQT2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038521749 ⟸ XM_038665821
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038393055 ⟸ XM_038537127
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0L8V6 (UniProtKB/TrEMBL), A0A8C0LXI9 (UniProtKB/TrEMBL), A0A8C0M0T8 (UniProtKB/TrEMBL), A0A8I3PQT2 (UniProtKB/TrEMBL), A0A8I3PRS1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038393056 ⟸ XM_038537128
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSCAFP00845033957 ⟸ ENSCAFT00845043331

Ensembl Acc Id:

ENSCAFP00845033879 ⟸ ENSCAFT00845043215

Ensembl Acc Id:

ENSCAFP00845034029 ⟸ ENSCAFT00845043434

Protein Domains

PCI

Promoters

RGD ID:

13683288

Promoter ID:

EPDNEW_C1356

Type:

initiation region

Name:

COPS3_1

Description:

COP9 signalosome subunit 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	5	42,143,455 - 42,143,515	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000018463	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030001979	UniProtKB/TrEMBL
	ENSCAFG00040003697	UniProtKB/TrEMBL
	ENSCAFG00845024449	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000029331.5	UniProtKB/TrEMBL
	ENSCAFT00000061725.2	UniProtKB/TrEMBL
	ENSCAFT00000063211.2	UniProtKB/TrEMBL
	ENSCAFT00030003585.1	UniProtKB/TrEMBL
	ENSCAFT00030003614.1	UniProtKB/TrEMBL
	ENSCAFT00030003656.1	UniProtKB/TrEMBL
	ENSCAFT00040007047.1	UniProtKB/TrEMBL
	ENSCAFT00040007059.1	UniProtKB/TrEMBL
	ENSCAFT00040007079.1	UniProtKB/TrEMBL
	ENSCAFT00845043215	ENTREZGENE
	ENSCAFT00845043215.1	UniProtKB/TrEMBL
	ENSCAFT00845043331.1	UniProtKB/TrEMBL
	ENSCAFT00845043434.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	1.25.40.570	UniProtKB/TrEMBL
InterPro	CSN3	UniProtKB/TrEMBL
	CSN3_C	UniProtKB/TrEMBL
	PCI_dom	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	COPS3	ENTREZGENE
PANTHER	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3	UniProtKB/TrEMBL
	PTHR10758:SF1	UniProtKB/TrEMBL
Pfam	COP9_hel_rpt	UniProtKB/TrEMBL
	CSN3-like_C	UniProtKB/TrEMBL
	PCI	UniProtKB/TrEMBL
PROSITE	PCI	UniProtKB/TrEMBL
SMART	PINT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A0A8C0L8V6	ENTREZGENE
	A0A8C0LXI9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0M0T8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0M353_CANLF	UniProtKB/TrEMBL
	A0A8I3PQT2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PR04_CANLF	UniProtKB/TrEMBL
	A0A8I3PRS1	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:39510	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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