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ONTOLOGY REPORT - ANNOTATIONS

Term:epidermal growth factor catabolic process
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Accession:GO:0007174 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.
Comment:This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.
Synonyms:exact_synonym: EGF breakdown;   EGF catabolism;   epidermal growth factor breakdown;   epidermal growth factor catabolism
 related_synonym: EGF receptor ligand processing;   epidermal growth factor ligand processing;   intracellular EGF processing;   receptor-mediated EGF processing


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epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB7A RAB7A, member RAS oncogene family involved_in IMP (PMID:18272684) BHF-UCL PMID:18272684 NCBI chr 3:128,726,183...128,814,798
Ensembl chr 3:128,693,669...128,825,942 		JBrowse link
G SNX5 sorting nexin 5 involved_in ISO
IEA		 RGD
Ensembl		 PMID:16487940 GO_REF:0000107 RGD:13508623 NCBI chr20:17,941,600...17,968,794
Ensembl chr20:17,941,597...17,968,980 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19613
    metabolic process 12439
      primary metabolic process 10668
        protein metabolic process 4395
          protein catabolic process 1082
            epidermal growth factor catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 19613
    biological regulation 13363
      regulation of biological process 12979
        signaling 7170
          signal transduction 6565
            cell surface receptor signaling pathway 3200
              enzyme-linked receptor protein signaling pathway 1161
                cell surface receptor protein tyrosine kinase signaling pathway 718
                  ERBB signaling pathway 139
                    epidermal growth factor receptor signaling pathway 119
                      regulation of epidermal growth factor receptor signaling pathway 66
                        negative regulation of epidermal growth factor receptor signaling pathway 24
                          epidermal growth factor catabolic process 2
paths to the root