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ONTOLOGY REPORT - ANNOTATIONS

Term:tRNA splicing, via endonucleolytic cleavage and ligation
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Accession:GO:0006388 term browser browse the term
Definition:Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
Comment:Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
Synonyms:narrow_synonym: tRNA-Y splicing

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tRNA splicing, via endonucleolytic cleavage and ligation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 involved_in ISO (PMID:24766809), (PMID:24766810)
(PMID:17495927)		 UniProt PMID:17495927 PMID:24766809 PMID:24766810 NCBI chrNW_004955511:2,588,825...2,592,108
Ensembl chrNW_004955511:2,588,825...2,593,192 		JBrowse link
G Ddx1 DEAD-box helicase 1 involved_in ISO (PMID:24870230) UniProt PMID:24870230 NCBI chrNW_004955487:9,085,950...9,117,599
Ensembl chrNW_004955487:9,085,918...9,119,979 		JBrowse link
G Rtcb RNA 2',3'-cyclic phosphate and 5'-OH ligase involved_in ISO (PMID:21311021), (PMID:24870230) UniProt PMID:21311021 PMID:24870230 NCBI chrNW_004955405:41,360,370...41,375,215
Ensembl chrNW_004955405:41,360,370...41,375,215 		JBrowse link
G Rtraf RNA transcription, translation and transport factor involved_in ISO (PMID:24870230) UniProt PMID:24870230 NCBI chrNW_004955409:11,034,815...11,049,400
Ensembl chrNW_004955409:11,034,815...11,049,878 		JBrowse link
G Trpt1 tRNA phosphotransferase 1 acts_upstream_of_or_within ISO (PMID:9826666) MGI PMID:9826666 NCBI chrNW_004955422:20,851,806...20,854,349
Ensembl chrNW_004955422:20,851,972...20,857,881 		JBrowse link
G Tsen2 tRNA splicing endonuclease subunit 2 involved_in ISO (PMID:17495927) UniProt PMID:17495927 NCBI chrNW_004955429:14,970,105...14,997,459
Ensembl chrNW_004955429:14,969,289...14,997,220 		JBrowse link
G Tsen54 tRNA splicing endonuclease subunit 54 involved_in ISO (PMID:17495927) UniProt PMID:17495927 NCBI chrNW_004955553:2,367,476...2,376,704
Ensembl chrNW_004955553:2,367,480...2,376,704 		JBrowse link
G Zbtb8os zinc finger and BTB domain containing 8 opposite strand involved_in ISO (PMID:24870230) UniProt PMID:24870230 NCBI chrNW_004955452:10,944,281...10,955,250
Ensembl chrNW_004955452:10,944,281...10,955,631 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7488
      primary metabolic process 6455
        RNA processing 583
          tRNA processing 86
            tRNA splicing, via endonucleolytic cleavage and ligation 8
              tRNA exon ligation 0
              tRNA-type intron splice site recognition and cleavage 0
Path 2
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7488
      primary metabolic process 6455
        nucleobase-containing compound metabolic process 3737
          nucleic acid metabolic process 3370
            RNA metabolic process 2899
              RNA biosynthetic process 2744
                RNA processing 583
                  RNA splicing 276
                    RNA splicing, via endonucleolytic cleavage and ligation 9
                      tRNA splicing, via endonucleolytic cleavage and ligation 8
                        tRNA exon ligation 0
                        tRNA-type intron splice site recognition and cleavage 0
paths to the root