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ONTOLOGY REPORT - ANNOTATIONS

Term:NMDA glutamate receptor activity
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Accession:GO:0004972 term browser browse the term
Definition:A cation channel that opens in response to binding by extracellular glutmate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.
Comment:The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product.
Synonyms:exact_synonym: N-methyl-D-aspartate selective glutamate receptor activity;   NMDA receptor
 xref: Wikipedia:NMDA_receptor


show annotations for term's descendants           Sort by:
NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 contributes_to
enables		 TAS
IDA
IMP
ISO
IGI		 (PMID:7679115), (PMID:7685113)
PMID:28384476
PMID:24876489
PMID:18177891
PMID:7929101
PMID:8428958
PMID:1834949
PMID:1388270
PMID:1350383
MGI:1928270|MGI:1928279|MGI:1928327|MGI:2387441|MGI:2448952|MGI:3611337|MGI:95820|MGI:95821|MGI:95822 (PMID:10963597), (PMID:12008020), (PMID:12040087), (PMID:12832526), (PMID:1374164), (PMID:1377365), (PMID:1385220), (PMID:14602821), (PMID:1532151), (PMID:15745956), (PMID:17313573), (PMID:7531804), (PMID:8060614), (PMID:8313466)
(PMID:24272827), (PMID:26875626), (PMID:26919761), (PMID:27164704), (PMID:28095420), (PMID:28105280), (PMID:28126851), (PMID:28228639), (PMID:38538865), (PMID:7681588), (PMID:7685113), (PMID:9489750)		 RGD PMID:1374164 PMID:1377365 PMID:1385220 PMID:1532151 PMID:7531804 More... RGD:727495, RGD:1642190, RGD:1642380, RGD:7241434, RGD:13432313, RGD:13432263, RGD:13432252, RGD:8553485, RGD:728651, RGD:407430007, RGD:407430004, RGD:727540 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A enables
contributes_to		 IDA
IMP
IEA
IBA
ISO		 PMID:28384476
PMID:23625947
GO_REF:0000117
GO_REF:0000033
MGI:1928285|MGI:1928506|MGI:95819 (PMID:11487658), (PMID:12754515), (PMID:1377365), (PMID:7816096), (PMID:8699248), (PMID:9427357), (PMID:9512392)
MGI:95819|RGD:2736 (PMID:1374164), (PMID:7929101)
(PMID:20890276), (PMID:23933819), (PMID:23933820), (PMID:24504326), (PMID:26875626), (PMID:26919761), (PMID:27288002), (PMID:28095420), (PMID:28126851), (PMID:28242877), (PMID:29644724), (PMID:36117210), (PMID:38307912), (PMID:38538865)		 UniProt
GO_Central
RGD		 PMID:1374164 PMID:1377365 PMID:7816096 PMID:7929101 PMID:8699248 More... GO_REF:0000033 GO_REF:0000117, RGD:728651, RGD:1642190, RGD:1642380, RGD:7241434, RGD:13432313, RGD:13432339 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B enables IDA
IEA
IBA
ISO		 PMID:24876489
PMID:28384476
GO_REF:0000117
GO_REF:0000033
MGI:1928293|MGI:1928295|MGI:95819|MGI:95823 (PMID:10634899), (PMID:12816890), (PMID:12832518), (PMID:1377365), (PMID:7531804), (PMID:9458051)
(PMID:24272827), (PMID:26919761), (PMID:38538865)		 UniProt
GO_Central
RGD		 PMID:1377365 PMID:7531804 PMID:9458051 PMID:10634899 PMID:12816890 More... GO_REF:0000033 GO_REF:0000117, RGD:727540, RGD:1642190, RGD:13432263, RGD:13432313 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C enables
contributes_to		 IDA
IEA
IBA
ISO		 GO_REF:0000117
GO_REF:0000033
RGD:2736 (PMID:7929101)
MGI:1928301|MGI:1928510|MGI:95819 (PMID:1377365), (PMID:8756432), (PMID:9427357), (PMID:9512392)
(PMID:26875626), (PMID:26919761)
PMID:1350383		 UniProt
GO_Central
RGD		 PMID:1377365 PMID:7929101 PMID:8756432 PMID:9427357 PMID:9512392 More... GO_REF:0000033 GO_REF:0000117, RGD:728651, RGD:727540 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D enables IDA
IMP
IBA
ISO		 PMID:23625947
GO_REF:0000033
MGI:1928298 (PMID:12832518), (PMID:1385220)
(PMID:26875626), (PMID:26919761), (PMID:9489750)		 GO_Central
RGD		 PMID:1385220 PMID:9489750 PMID:12832518 PMID:26875626 PMID:26919761 More... GO_REF:0000033, RGD:728580, RGD:1642380, RGD:1642397, RGD:13432339 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A contributes_to
enables		 TAS
IDA
ISO
IEA
IBA		 PMID:17182766
(PMID:17502428)
GO_REF:0000107
GO_REF:0000033
MGI:2387963|PR:P35438 (PMID:14507892), (PMID:9620802)		 RGD
Ensembl
GO_Central		 PMID:9620802 PMID:14507892 PMID:17502428 PMID:9891978 PMID:16477151 More... GO_REF:0000033 GO_REF:0000107, RGD:632837, RGD:1642190, RGD:8553928 NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20626
    transporter activity 1253
      transmembrane transporter activity 1153
        amino acid transmembrane transporter activity 103
          glutamate-gated receptor activity 16
            NMDA glutamate receptor activity 7
Path 2
Term Annotations click to browse term
  molecular_function 20626
    transporter activity 1253
      transmembrane transporter activity 1153
        passive transmembrane transporter activity 511
          channel activity 511
            gated channel activity 334
              ligand-gated channel activity 190
                ligand-gated monoatomic ion channel activity 185
                  extracellular ligand-gated monoatomic ion channel activity 70
                    transmitter-gated monoatomic ion channel activity 60
                      glutamate-gated receptor activity 16
                        NMDA glutamate receptor activity 7
paths to the root