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ONTOLOGY REPORT - ANNOTATIONS

Term:glucosylceramidase activity
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Accession:GO:0004348 term browser browse the term
Definition:Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
Synonyms:related_synonym: D-glucosyl-N-acylsphingosine glucohydrolase activity;   GlcCer-beta-glucosidase activity;   acid beta-glucosidase activity;   beta-D-glucocerebrosidase activity;   beta-glucocerebrosidase activity;   beta-glucosylceramidase activity;   ceramide glucosidase activity;   glucocerebrosidase activity;   glucosphingosine glucosylhydrolase activity;   glucosylcerebrosidase activity;   glucosylsphingosine beta-D-glucosidase activity;   glucosylsphingosine beta-glucosidase activity;   psychosine hydrolase activity
 xref: EC:3.2.1.45;   MetaCyc:GLUCOSYLCERAMIDASE-RXN;   RHEA:13269;   Reactome:R-HSA-1605591 "GBA1:SAPC hydrolyzes GlcCer";   Reactome:R-HSA-1861788 "GBA2 hydrolyzes GlcCer (plasma membrane)";   Reactome:R-HSA-1861789 "GBA3 hydrolyzes GlcCer (cytosol)"

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glucosylceramidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G N Gba1 glucosylceramidase beta 1 enables ISO
IEA		 RGD
TreeGrafter
RHEA
InterPro
UniProt		 PMID:6426948 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000118 RGD:5508440 NCBI chrNW_004624885:2,315,371...2,321,327
Ensembl chrNW_004624885:2,315,142...2,321,327 		JBrowse link
G G GBA1 glucosylceramidase beta 1 enables ISO (MGI:5141165|PMID:21700325), (MGI:5501380|PMID:23707074), (PMID:22659419)
(MGI:6271235|PMID:24211208), (PMID:22659419)
(PMID:15916907), (PMID:21700325), (PMID:23580063), (PMID:25584808)
(PMID:16293621), (PMID:19279011), (PMID:24211208), (PMID:9201993)		 RGD
ParkinsonsUK-UCL
MGI
UniProt		 PMID:6426948 PMID:9201993 PMID:15916907 PMID:16293621 PMID:19279011 More... MGI:5141165 MGI:5501380 MGI:6271235 RGD:5508440 NCBI chr20:8,598,110...8,631,517
Ensembl chr20:8,598,628...8,630,990 		JBrowse link
G P GBA1 glucosylceramidase beta 1 enables ISO
IEA
IBA
ISS		 RGD
TreeGrafter
GO_Central
UniProt
RHEA
Ensembl
InterPro		 PMID:6426948 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:5508440 NCBI chr 4:94,583,905...94,606,689
Ensembl chr 4:94,584,134...94,609,745 		JBrowse link
G S Gba1 glucosylceramidase beta 1 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl
RHEA
UniProt		 PMID:6426948 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:5508440 NCBI chrNW_004936580:4,715,869...4,720,752
Ensembl chrNW_004936580:4,715,408...4,720,798 		JBrowse link
G D GBA1 glucosylceramidase beta 1 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:6426948 GO_REF:0000002 GO_REF:0000107 RGD:5508440 NCBI chr 7:42,317,704...42,322,285
Ensembl chr 7:42,317,862...42,322,864 		JBrowse link
G B GBA1 glucosylceramidase beta 1 enables IEA
ISO		 InterPro
TreeGrafter
RGD
UniProt
Ensembl
RHEA		 PMID:6426948 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:5508440 NCBI chr 1:130,579,300...130,589,560
Ensembl chr 1:134,185,385...134,194,851 		JBrowse link
G C Gba1 glucosylceramidase beta 1 enables ISO (MGI:6271235|PMID:24211208), (PMID:22659419)
(MGI:5141165|PMID:21700325), (MGI:5501380|PMID:23707074), (PMID:22659419)
(PMID:15916907), (PMID:21700325), (PMID:23580063), (PMID:25584808)
(PMID:16293621), (PMID:19279011), (PMID:24211208), (PMID:9201993)		 RGD
MGI
ParkinsonsUK-UCL
UniProt		 PMID:6426948 PMID:9201993 PMID:15916907 PMID:16293621 PMID:19279011 More... MGI:5141165 MGI:5501380 MGI:6271235 RGD:5508440 NCBI chrNW_004955545:1,682,097...1,689,373
Ensembl chrNW_004955545:1,682,097...1,689,376 		JBrowse link
G R Gba1 glucosylceramidase beta 1 enables IDA
ISO
IBA		 (MGI:5141165|PMID:21700325), (MGI:5501380|PMID:23707074), (MGI:6271235|PMID:24211208), (PMID:22659419)
GO_REF:0000033
(PMID:15916907), (PMID:16293621), (PMID:19279011), (PMID:21700325), (PMID:23580063), (PMID:24211208), (PMID:25584808), (PMID:9201993)		 RGD
GO_Central		 PMID:9201993 PMID:15916907 PMID:16293621 PMID:19279011 PMID:21700325 More... GO_REF:0000033 MGI:5141165 MGI:5501380 MGI:6271235, RGD:5508440 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G M Gba1 glucosylceramidase beta 1 enables ISO
IDA
IMP
IBA		 (MGI:6271235|PMID:24211208), (PMID:22659419)
(MGI:5141165|PMID:21700325), (MGI:5501380|PMID:23707074), (PMID:22659419)		 MGI
ParkinsonsUK-UCL
GO_Central
RGD		 PMID:6426948 PMID:21700325 PMID:22659419 PMID:23707074 PMID:24211208 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:5141165 MGI:5501380 MGI:6271235 RGD:5508440 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G H GBA1 glucosylceramidase beta 1 enables ISO
IEA
IBA
IMP
IDA		 (PMID:15916907), (PMID:21700325), (PMID:23580063), (PMID:25584808)
(PMID:16293621), (PMID:19279011), (PMID:24211208), (PMID:9201993)		 RGD
TreeGrafter
GO_Central
ParkinsonsUK-UCL
Ensembl
UniProt
InterPro
RHEA		 PMID:6426948 PMID:9201993 PMID:15916907 PMID:16293621 PMID:19279011 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:5508440 NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,452...155,244,699 		JBrowse link
G N Gba2 glucosylceramidase beta 2 enables IEA InterPro
Ensembl
UniProt
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chrNW_004624868:5,045,566...5,056,419
Ensembl chrNW_004624868:5,045,594...5,056,416 		JBrowse link
G G GBA2 glucosylceramidase beta 2 enables IEA RHEA
Ensembl
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr12:44,852,048...44,865,542
Ensembl chr12:44,852,203...44,868,652 		JBrowse link
G P GBA2 glucosylceramidase beta 2 enables IEA InterPro
UniProt
RHEA
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr 1:236,456,238...236,467,887
Ensembl chr 1:236,455,240...236,468,210 		JBrowse link
G S Gba2 glucosylceramidase beta 2 enables IEA RHEA
Ensembl
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chrNW_004936524:3,730,833...3,742,526
Ensembl chrNW_004936524:3,730,833...3,742,531 		JBrowse link
G D GBA2 glucosylceramidase beta 2 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr11:52,264,959...52,277,298
Ensembl chr11:52,265,070...52,277,213 		JBrowse link
G B GBA2 glucosylceramidase beta 2 enables IEA Ensembl
RHEA
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr 9:35,587,876...35,599,971
Ensembl chr 9:36,390,409...36,402,949 		JBrowse link
G C Gba2 glucosylceramidase beta 2 enables ISO (PMID:17080196)
(MGI:3690511|PMID:17080196), (MGI:5484792|PMID:23250757), (PMID:22659419)
(PMID:22659419)		 UniProt
MGI		 PMID:17080196 PMID:22659419 PMID:23250757 MGI:3690511 MGI:5484792 NCBI chrNW_004955472:553,556...564,411
Ensembl chrNW_004955472:553,556...564,411 		JBrowse link
G R Gba2 glucosylceramidase beta 2 enables IEA
ISO
ISS		 GO_REF:0000003
(MGI:3690511|PMID:17080196), (MGI:5484792|PMID:23250757), (PMID:22659419)
GO_REF:0000024
(PMID:17080196)		 UniProt
RGD		 PMID:17080196 PMID:22659419 PMID:23250757 GO_REF:0000003 GO_REF:0000024 MGI:3690511 MGI:5484792 NCBI chr 5:57,822,389...57,834,522
Ensembl chr 5:57,822,389...57,834,072 		JBrowse link
G M Gba2 glucosidase beta 2 enables ISO
IMP
IDA		 (PMID:22659419)
(MGI:3690511|PMID:17080196), (MGI:5484792|PMID:23250757), (PMID:22659419)		 MGI
UniProt		 PMID:17080196 PMID:22659419 PMID:23250757 GO_REF:0000119 MGI:3690511 MGI:4834177 MGI:5484792 NCBI chr 4:43,566,928...43,578,893
Ensembl chr 4:43,566,928...43,578,873 		JBrowse link
G H GBA2 glucosylceramidase beta 2 enables IEA
TAS
IDA		 (PMID:17080196) Ensembl
UniProt
RHEA
InterPro
Reactome		 PMID:17080196 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 Reactome:R-HSA-1861788 NCBI chr 9:35,736,866...35,749,228
Ensembl chr 9:35,736,866...35,749,228 		JBrowse link
G P GBA3 glucosylceramidase beta 3 enables ISO (PMID:26724485) UniProt PMID:26724485 NCBI chr 8:16,897,275...17,012,886
Ensembl chr 8:16,897,288...17,044,570 		JBrowse link
G D GBA3 glucosylceramidase beta 3 enables ISO (PMID:26724485) UniProt PMID:26724485 NCBI chr 3:87,080,351...87,190,931
Ensembl chr 3:87,081,134...87,190,987 		JBrowse link
G R Gba3 glucosylceramidase beta 3 enables ISO (PMID:26724485) RGD PMID:26724485 NCBI chr14:60,574,974...60,721,411
Ensembl chr14:60,574,976...60,721,653 		JBrowse link
G H GBA3 glucosylceramidase beta 3 (gene/pseudogene) enables IEA
TAS
IDA		 (PMID:26724485) RHEA
Reactome
UniProt		 PMID:26724485 GO_REF:0000116 Reactome:R-HSA-1861789 NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575 		JBrowse link
G N Lct lactase enables ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chrNW_004624732:35,125,995...35,177,055
Ensembl chrNW_004624732:35,125,287...35,175,062 		JBrowse link
G G LCT lactase enables ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chr10:19,994,398...20,049,325
Ensembl chr10:19,994,384...20,049,097 		JBrowse link
G S Lct lactase enables ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chrNW_004936469:40,064,822...40,108,423
Ensembl chrNW_004936469:40,064,822...40,107,447 		JBrowse link
G D LCT lactase enables ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chr19:38,571,539...38,620,567
Ensembl chr19:38,572,058...38,620,567 		JBrowse link
G B LCT lactase enables ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chr2B:24,025,383...24,079,779
Ensembl chr2B:139,855,605...139,908,764 		JBrowse link
G C Lct lactase enables ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chrNW_004955440:3,148,730...3,197,110
Ensembl chrNW_004955440:3,148,730...3,197,110 		JBrowse link
G R Lct lactase enables IDA PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456 		JBrowse link
G M Lct lactase enables ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 1:128,212,493...128,256,055
Ensembl chr 1:128,212,493...128,256,055 		JBrowse link
G H LCT lactase enables ISS UniProt GO_REF:0000024 NCBI chr 2:135,787,850...135,837,184
Ensembl chr 2:135,787,850...135,837,184 		JBrowse link
G P LOC100625897 lactase-phlorizin hydrolase enables ISO PMID:4752949 UniProt PMID:4752949 RGD:151356630 NCBI chr15:16,094,277...16,154,467 JBrowse link
G G LOC119623630 lysosomal acid glucosylceramidase enables IEA UniProt
InterPro
RHEA
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 189906
    catalytic activity 54002
      hydrolase activity 22736
        hydrolase activity, acting on glycosyl bonds 1257
          hydrolase activity, hydrolyzing O-glycosyl compounds 962
            glucosylceramidase activity 35
paths to the root