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Gene: LCT (lactase) Pan paniscus

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Symbol:

LCT

Name:

lactase

RGD ID:

11741139

Description:

ENCODES a protein that exhibits galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); lactase activity (ortholog); INVOLVED IN glycosylceramide catabolic process (ortholog); response to estrogen (ortholog); response to ethanol (ortholog); PARTICIPATES IN galactose metabolic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lactase-phlorizin hydrolase; lactase/phlorizin hydrolase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LCT (lactase)	NCBI	Ortholog
Mus musculus (house mouse):	Lct (lactase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lct (lactase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lct (lactase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LCT (lactase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lct (lactase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100625897 (lactase-phlorizin hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LCT (lactase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lct (lactase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	39,093,531 - 39,150,819 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	39,108,500 - 39,162,817 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	24,025,383 - 24,079,779 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	139,855,600 - 139,908,764 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	139,855,605 - 139,908,764 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (ISO)

colitis (ISO)

congenital lactase deficiency (ISO)

diarrhea (ISO)

Experimental Diabetes Mellitus (ISO)

genetic disease (ISO)

lactose intolerance (ISO)

WHIM Syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (IEA)

cellobiose catabolic process (IEA)

glycosylceramide catabolic process (ISO)

lactose catabolic process (IEA)

quercetin catabolic process (IEA)

response to estrogen (ISO)

response to ethanol (ISO)

response to hormone (ISO)

response to hypoxia (ISO)

response to iron(II) ion (ISO)

response to lead ion (ISO)

response to nickel cation (ISO)

response to nutrient (ISO)

response to starvation (ISO)

response to sucrose (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

brush border (ISO)

external side of apical plasma membrane (IEA)

membrane (IEA)

Molecular Function

beta-glucosidase activity (IEA)

galactosylceramidase activity (ISO)

glucosylceramidase activity (ISO)

hydrolase activity, acting on glycosyl bonds (IEA)

hydrolase activity, hydrolyzing O-glycosyl compounds (IEA)

lactase activity (IEA,ISO)

phlorizin hydrolase activity (IEA)

protein homodimerization activity (IEA)

transferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

galactose metabolic pathway (ISO)

galactosemia pathway (ISO)

lactose degradation pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LCT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	39,093,531 - 39,150,819 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	39,108,500 - 39,162,817 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	24,025,383 - 24,079,779 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	139,855,600 - 139,908,764 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	139,855,605 - 139,908,764 (-)	Ensembl	panpan1.1		panPan2

LCT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	135,787,850 - 135,837,184 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	135,787,850 - 135,837,184 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	136,545,420 - 136,594,754 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	136,261,885 - 136,311,220 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	136,379,146 - 136,428,482	NCBI
Celera	2	130,256,175 - 130,305,504 (-)	NCBI		Celera
Cytogenetic Map	2	q21.3	NCBI
HuRef	2	128,538,586 - 128,587,979 (-)	NCBI		HuRef
CHM1_1	2	136,550,605 - 136,600,149 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	136,228,325 - 136,281,636 (-)	NCBI		T2T-CHM13v2.0

Lct
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	128,212,493 - 128,256,055 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	128,212,493 - 128,256,055 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	128,284,756 - 128,328,318 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	128,284,756 - 128,328,318 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	130,181,341 - 130,224,895 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	130,112,310 - 130,155,864 (-)	NCBI		MGSCv36	mm8
Celera	1	130,912,375 - 130,955,221 (-)	NCBI		Celera
Cytogenetic Map	1	E3	NCBI
cM Map	1	55.8	NCBI

Lct
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	42,334,347 - 42,376,872 (-)	NCBI		GRCr8
mRatBN7.2	13	39,781,929 - 39,824,456 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	39,781,929 - 39,824,456 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	42,375,821 - 42,418,341 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	43,663,926 - 43,706,446 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	40,917,951 - 40,960,284 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	44,998,414 - 45,040,593 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	44,998,414 - 45,040,593 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	50,083,769 - 50,125,203 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	40,990,315 - 41,043,388 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	41,017,068 - 41,018,494 (-)	NCBI
Celera	13	40,155,673 - 40,198,507 (-)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

Lct
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	3,148,730 - 3,197,110 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955440	3,148,730 - 3,197,110 (-)	NCBI	ChiLan1.0	ChiLan1.0

LCT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	38,571,539 - 38,620,567 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	38,572,058 - 38,620,567 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	38,812,141 - 38,863,510 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	40,014,481 - 40,065,894 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	40,017,274 - 40,065,921 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	38,656,504 - 38,707,872 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	38,815,944 - 38,867,284 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	40,048,815 - 40,100,194 (-)	NCBI		UU_Cfam_GSD_1.0

Lct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	101,510,063 - 101,552,920 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	40,064,822 - 40,107,447 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	40,064,822 - 40,108,423 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100625897
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	15	16,094,277 - 16,154,467 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	18,486,673 - 18,544,563 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LCT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	19,994,398 - 20,049,325 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	19,994,384 - 20,049,097 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	2,414,641 - 2,469,654 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lct
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	35,125,287 - 35,175,062 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	35,125,995 - 35,177,055 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003822810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000005436 ⟹ ENSPPAP00000001152

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2B	139,855,605 - 139,908,764 (-)	Ensembl

RefSeq Acc Id:

XM_003822810 ⟹ XP_003822858

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	13	39,093,531 - 39,150,819 (+)	NCBI
NHGRI_mPanPan1	2B	39,108,500 - 39,162,817 (+)	NCBI
Mhudiblu_PPA_v0	2B	24,025,383 - 24,079,779 (+)	NCBI
PanPan1.1	2B	139,855,600 - 139,908,764 (-)	NCBI

Sequence:

show sequence

GTTCCTAGAAAATGGAGCTGTCTTGGCATGTAGTCTTTATTGCCCTGCTAAGTTTTTCATGCTG
GGGGTCAGACTGGGAGTCTGATAGAAATTTCATTTCCACCGCTGGTCCTCTAACCAATGACTTG
CTGCACAACCTGAGTGGTCTCCTGGGAGACCAGAGTTCTAACTTTGTAGCAGGGGACAAAGACA
TGTATGTTTGTCACCAGCCACTGCCCACTTTCCTGCCAGAATACTTCAGCAGTCTCCATGCCAG
TCAGATCACCCATTATAAGGTATTTCTGTCATGGGCACAACTCCTCCCAGCAGGAAGCACCCAG
AATCCAGACGAGAAAACAGTGCAGTGCTACCGGCGACTCCTCGAGGCCCTCAAGACTGCACGGC
TTCAGCCCATGGTCATCCTGCACCACCAGACCCTCCCTGCCAGCACCCTCCGGAGAACCGAAGC
CTTCGCTGACCTCTTCGCCGACTATGCCACATTCGCCTTCCACTCCTTTGGGGACCTAGTTGGG
ATCTGGTTCACCTTCAGTGACTTGGAGGAAGTGATCAAGGAGCTTCCCCACCAGGAATCAAGAG
CGTCACAACTCCAGACCCTCAGTGATGCCCACAGAAAAGCCTATGAGATTTACCACGAAAACTA
TGCTTCTCAGGGCGGAAAACTCTCTGTTGTCCTGCGAGCTGAAGATATCCCGGAGCTCCTGCTA
GAACCACCCATATCTGCGCTTGCCCAGGACGCGGTCGATTTCCTCTCTCTTGATTTGTCTTATG
AATGCCAAAATGAGGCAAGTCTGCGGCAGAAGCTGAGTAAATTGCAGACCATTGAGCCAAAAGT
GAAAGTTTTCATCTTCAACCTAAAACTCCCGGACTGCCCCTCCACCATGAAGAACCCAGCCAGT
CTGCTCTTCAGCCTTTTTGAAGCCATAAATAAAGACCAAGTGCTCACCATTGGGTTTGATATTA
ATGAGTTTCTGAGTTGTTCATCAAGTTCCAAGAAAAGCATGTCTTGTTCTCTGACTGGCAGCCT
GGCCCTTCAGCCTGACCAGCAGCAGGACCACGAGACCACGGACTCCTCTCCTGCCTCTGCCTAT
CAGAGAGTCTGGGAAGCATTTGCCAATCAGTCCAGGGCGGAAAGGGATGCCTTCCTGCAGGATA
CTTTCCCTGAAGGCTTCCTCTGGGGTGCCTCCACAGGAGCCTTTAACGTGGAAGGAGGCTGGGC
CGAGGGTGGGAGAGGGGCGAGCATCTGGGATCCACGCAGGCTCCTGAACACCACTGAGGGCCAA
GCGACGCCGGAGGTGGCCAGCGACAGCTACCACAAGGTAGCCTCTGACGTCGCCCTGCTTCGCG
GCCTCCGGGCTCAGGTGTACAAGTTCTCCATCTCCTGGTCCCGGATCTTCCCCATGGGGCACGG
GAGCAGCCCCAGCCTCCCAGGCGTTGCCTACTACAACAAGCTGATTGACAGCCTACAGGATGCG
GGCATCGAGCCCATGGCCACGCTGTTCCACTGGGACCTGCCTCAGGCCCTGCAGGATCATGGTG
GATGGCAGAATGAGAGCGTGGTGGATGCCTTCCTGGACTATGCGGCCTTCTGCTTCTCCACATT
TGGGGACCGTGTGAAGCTGTGGGTGACCTTCCATGAGCCGTGGGTGATGAGCTACGCAGGCTAT
GGCACCGGTCAGCACCCTCCCGGCATCTCTGACCCAGGAGTGGCCTCTTTTAAGGTGGCTCACT
TGGTCCTCAAGGCTCATGCCAGAACTTGGCACCACTACAACAGCCACCATCGCCCACAGCAGCA
GGGGCACGTGGGCATTGTGCTGAACTCAGACTGGGCAGAACCCCTGTCTCCAGAGAGGCCTGAG
GACCTAAGAGCCTCTGAGCGCTTCTTGCACTTCATGCTGGGCTGGTTTGCACACCCTGTCTTTG
TGGATGGAGACTACCCAGCCACCCTGAGGACCCAGATCCAACAGATGAACAGACAGTGCTCCCA
TCCTGTGGCTCAACTCCCCGAGTTCACAGAGGCAGAGAAGCAGCTCCTGAAAGGCTCTGCTGAT
TTTCTGGGTCTGTCGCATTACACCTCCCGCCTCATCAGCAACGCCCCACAAAACACCTGCATCC
CTAGCTATGATACCATTGGAGGCTTCTCCCAACACGTGAACCATGTGTGGCCCCAGACCTCATC
CTCTTGGATTCGTGTGGTGCCCTGGGGGATAAGGAGGCTGTTGCAGTTTGTATCCCTGGAATAC
ACAAGAGGAAAAGTTCCAATATACCTTGCCGGGAATGGCATGCCCATAGGGGAAAGTGAAAATC
TCTTTGATGATTCCTTGAGAGTAGACTACTTCAATCAATATATCAATGAGGTGCTCAAGGCTAT
CAAGGAAGACTCTGTGGATGTTCGTTCCTACATTGCTCGTTCCCTCATTGATGGCTTCGAAGGC
CCTTCTGGTTACAGCCAGCGGTTTGGCCTGCACCACGTCAACTTCAGCGACAGCAGCAAGTCAA
GGACTCCCAGGAAATCTGCCTACTTTTTCACTAGCATCATAGAAAAGAACGGTTTCCTCACCAA
GGGGGCAAAAAGACTGCTACCACCTAATACAGTAAACCTCCCCTCCAAAGTCAGAGCCTTCACT
TTTCCATCTGAGGTGCCCTCCAAGGCTAAAGTCGTTTGGGAAAAGTTCTCCAGCCAACCCAAGT
TCGAAAGAGATTTGTTCTACCACGGGACGTTTCGGGATGACTTTCTGTGGGGCGTGTCCTCTTC
CGCTTATCAGATTGAAGGCGGGTGGGATGCCGATGGCAAAGGCCCCAGCATCTGGGATAACTTT
ACCCACACACCAGGGAGCAATGTGAAAGACAATGCCACTGGAGACATCGCCTGTGACAGCTATC
ACCAGCTGGATGCCGATCTGAATATGCTCCGAGCTTTGAAGGTGAAGGCCTACCGCTTCTCTAT
CTCCTGGTCTCGGATTTTCCCAACTGGGAGAAACAGCTCTATCAACAGTCATGGGGTTGATTAT
TACAACAGGCTGATCAATGGCTTGGTGGCAAGCAACATCTTTCCCATGGTGACATTGTTCCATT
GGGACCTGCCCCAGGCCCTCCAGGATATCGGAGGCTGGGAGAATCCTGCCTTGATTGACTTGTT
TGACAGCTACGCAGACTTTTGTTTCCAGACCTTTGGTGATAGAGTCAAGTTTTGGATGACTTTT
AATGAGCCCATGTACCTGGCATGGCTGGGTTATGGCTCAGGGGAATTTCCCCCAGGGGTGAAGG
ACCCAGGCTGGGCACCATATAGGATAGCCCACGCCGTCATCAAAGCCCATGCCAGAGTCTATCA
CACGTACAATGAGAAATACAGGCAGGAGCAGAAGGGGGTCATCTCGCTGAGCCTCAGTACACAC
TGGGCAGAGCCCAAGTCACCAGGGGTCCCCAGAGATGTGGAAGCCGCTGACCGAATGCTGCAGT
TCTCCCTGGGCTGGTTTGCTCACCCCATTTTTAGAAACGGAGACTATCCTGACACCATGAAGTG
GAAAGTGGGGAACAGGAGTGAACTGCAGCACTTAGCCACCTCCCGCCTGCCAAGCTTCACTGAG
GAAGAGAAGAGGTTCATCAGGGCGACGGCCGACGTCTTCTGCCTCAACACGTACTACTCCAGAA
TCGTGCAGTACAAAACACCCAGGCTAAACCCACCCTCCTACGAAGACGACCGGGAGATGGCCGA
GGAGGAGGACCCTTCGTGGCCTTCCACGGCAATGAACAGAGCTGCGCCCTGGGGGACGCGAAGG
CTGCTGAACTGGATCAAGGAAGAGTATGGTGACATCCCCATTTACATCACCGAAAACGGAGTGG
GGCTGACCAATCCGAACACGGAGGATACTGATAGGATATTTTACCACAAAACCTACATCAATGA
GGCTTTGAAAGCCTACAGGCTCGATGGTATAGACCTTCGAGGGTATGTCGCCTGGTCTCTGATG
GACAACTTTGAGTGGCTAAATGGCTACACGGTCAAGTTTGGACTGTACCATGTTGATTTCAACA
ACACGAACAGGCCTCGCACAGCAAGAGCCTCCGCCAGGTACTACACAGAGGTCATTAGCAACAA
CGGCATGCCACTGGCCAGGGAGGATGAGTTTCTGTACGGACGGTTTCCTGAGGGCTTCATCTGG
AGTGCAGCTTCTGCTGCATATCAGATTGAAGGTGCGTGGAGAGCAGATGGCAAAGGACTCAGCA
TTTGGGACACGTTTTCTCACACACCACTGAGGGTTGAGAACGATGCCATTGGAGATGTGGCCTG
TGACAGTTATCACAAGATTGCTGAGGATCTGGTCACCCTGAAGAACCTGGGCGTGTCCCACTAC
CGTTTTTCCATCTCCTGGTCTCGCATCCTCCCTGATGGAACCACCAGGTACATCAATGAAGCGG
GCCTGAACTACTACGTGAGGCTCATCGATACACTGCTGGCCGCCAGCATCCAGCCCCAGGTGAC
CATTTACCACTGGGACCTACCACAGACGCTCCAAGATGTAGGAGGCTGGGAGAATGAGACCATC
GTGCAGCGGTTTAAGGAGTATGCAGATGTGCTCTTCCAGAGGCTGGGAGACAAGGTGAAGTTTT
GGATCACGCTGAATGAGCCCTTTGTCATTGCTTACCAGGGCTATGGCTACGGAACAGCAGCTCC
AGGAATCTCCAATAGGCCTGGCACTGCCCCGTACATTGTTGGCCACAATCTAATAAAGGCTCAT
GCTGAGGCCTGGCATCTGTACAACGATGTGTACCGCGCCAGTCAAGGTGGCGTGATTTCCATCA
CCATCAGCAGTGACTGGGCTGAACCCAGAGATCCCTCTAACCAGGAGGATGTGGAGGCAGCCAG
GAGATATGTTCAGTTCATGGGAGGCTGGTTTGCACATCCTATTTTCAAGAATGGAGATTACAAT
GAGGTGATGAAGACGCGGATCCGTGACAGGAGCTTGGCTGCAGGCCTCAACAAGTCTCGGCTGC
CAGAATTTACAGAGAGTGAGAAGAGGAGGATCAACGGCACCTATGACTACTTTGGGTTCAATCA
CTACACCACTGTCCTCGCCTACAACCTCAACTACGACACTGCCATCTCTTCTTTTGATGCAGAC
AGAGGAGTTGCTTCCATCGCAGATCGCTCGTGGCCAGACTCTGGCTCCTTCTGGCTGAAGATGA
CGCCTTTTGGCTTCAGGAGGATCCTGAACTGGTTAAAGGAGGAATACAATGACCCTCCAATTTA
TGTCACAGAGAATGGAGTGTCCCAGCGGGAAGAAACAGACCTCAATGACACTGCAAGGATCTAC
TACCTTCGGACTTACATCAATGAGGCCCTCAAAGCTGTGCAGGACAAGGTGGACCTTCGAGGAT
ACACAGTTTGGAGTGCGATGGACAATTTTGAGTGGGCCACAGGCTTTTCGGAGAGATTTGGTCT
GCATTTTGTGAACTACAGTGACCCTTCTCTGCCAAGGATCCCCAAAGCATCAGCGAAGTTCTAC
GCCTCTGTGGTCCGATGCAATGGCTTCCCTGACCCCGCTACAGGGCCTCACGCTTGTCTCCGCC
AGCCAGATGCTGGACCCACCATCAGCCCCGTGAGACAGGAGGAGGTGCAGTTCCTGGGGCTAAT
GCTCGGCACCACAGAAGCACAGACAGCTTTGTACGTTCTCTTTTCTCTTGTGCTTCTTGGAGTC
TGTGGCTTGGCATTTCTGTCATACAAGTACTGCAAGCGCTCTAAGCAAGGGAAAACACAACGAA
GCCAACAGGAATTGAGCCAGGTGTCTTCATTCTGATGAGTTACCACCTCAAGTTCTATGAAGCA
GGCCTAGTTTCTTCATCTATCTTTACCGACCACCAAATGCCTTAGGGTCTTAGACTCTGCTTAT
ACTGGACTTCTCCATAAAGTCCTGCTGCACCGTTAGAGATGACTTTAATCTTGAATGATTTCGA
CTTGCTGATTAAAATGGAAATATCTCCATCTTGCTCCAGTATCAGAGTTCATTTGGGCATTTGA
GAAGCAAGTAGCTCTTGCGGAAACGTGTAGATACTGGTCTAGTGGGTCTGTGAACCATTTAATT
GAACTTAACAGGGCTGTTTTAAGTTTCAGAGTTGTTAAGGGTTGTTAAGGGAGCAAAAACCGTA
AAAATCCTTTCTATAAGAAGAAATCAACTCCATTGCATAGACTGCAATATCATCTCCTGCCCTT
CTGCAAGCTCTCCCTAGCTTCACATCTTGTGTTTTCCAGAAAATAAAAACAGCAGACTGTCCTT
TCTCCTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003822858	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000001152.1

RefSeq Acc Id:

XP_003822858 ⟸ XM_003822810

- UniProtKB:

A0A2R8Z8C5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKDMYVC
HQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLEALKTARLQPM
VILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKELPHQESRASQL
QTLSDAHRKAYEIYHENYASQGGKLSVVLRAEDIPELLLEPPISALAQDAVDFLSLDLSYECQN
EASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSLFEAINKDQVLTIGFDINEFL
SCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQRVWEAFANQSRAERDAFLQDTFPE
GFLWGASTGAFNVEGGWAEGGRGASIWDPRRLLNTTEGQATPEVASDSYHKVASDVALLRGLRA
QVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDSLQDAGIEPMATLFHWDLPQALQDHGGWQN
ESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLK
AHARTWHHYNSHHRPQQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGD
YPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYD
TIGGFSQHVNHVWPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDD
SLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPR
KSAYFFTSIIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERD
LFYHGTFRDDFLWGVSSSAYQIEGGWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWDLP
QALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPGVKDPGW
APYRIAHAVIKAHARVYHTYNEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEAADRMLQFSLG
WFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTYYSRIVQY
KTPRLNPPSYEDDREMAEEEDPSWPSTAMNRAAPWGTRRLLNWIKEEYGDIPIYITENGVGLTN
PNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNR
PRTARASARYYTEVISNNGMPLAREDEFLYGRFPEGFIWSAASAAYQIEGAWRADGKGLSIWDT
FSHTPLRVENDAIGDVACDSYHKIAEDLVTLKNLGVSHYRFSISWSRILPDGTTRYINEAGLNY
YVRLIDTLLAASIQPQVTIYHWDLPQTLQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITL
NEPFVIAYQGYGYGTAAPGISNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISS
DWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFT
ESEKRRINGTYDYFGFNHYTTVLAYNLNYDTAISSFDADRGVASIADRSWPDSGSFWLKMTPFG
FRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVW
SAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLRQPDA
GPTISPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
LSQVSSF

hide sequence

Ensembl Acc Id:

ENSPPAP00000001152 ⟸ ENSPPAT00000005436

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000005000	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000005436.1	UniProtKB/TrEMBL
Gene3D-CATH	Glycosidases	UniProtKB/TrEMBL
InterPro	Glyco_hydro_1	UniProtKB/TrEMBL
	Glyco_hydro_1_AS	UniProtKB/TrEMBL
	Glyco_hydro_1_N_CS	UniProtKB/TrEMBL
	Glycoside_hydrolase_SF	UniProtKB/TrEMBL
KEGG Report	pps:100993974	UniProtKB/TrEMBL
NCBI Gene	LCT	ENTREZGENE
PANTHER	LACTASE-LIKE PROTEIN	UniProtKB/TrEMBL
	PTHR10353	UniProtKB/TrEMBL
Pfam	Glyco_hydro_1	UniProtKB/TrEMBL
PRINTS	GLHYDRLASE1	UniProtKB/TrEMBL
PROSITE	GLYCOSYL_HYDROL_F1_1	UniProtKB/TrEMBL
	GLYCOSYL_HYDROL_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51445	UniProtKB/TrEMBL
UniProt	A0A2R8Z8C5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB