LCT (lactase) - Rat Genome Database

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Gene: LCT (lactase) Pan paniscus
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Symbol: LCT
Name: lactase
RGD ID: 11741139
Description: ENCODES a protein that exhibits galactosylceramidase activity (ortholog); glucosylceramidase activity (ortholog); lactase activity (ortholog); INVOLVED IN glycosylceramide catabolic process (ortholog); response to estrogen (ortholog); response to ethanol (ortholog); PARTICIPATES IN galactose metabolic pathway; galactosemia pathway; lactose degradation pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); colitis (ortholog); congenital lactase deficiency (ortholog); FOUND IN brush border (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lactase-phlorizin hydrolase; lactase/phlorizin hydrolase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B39,108,500 - 39,162,817 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B24,025,383 - 24,079,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B139,855,600 - 139,908,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B139,855,605 - 139,908,764 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LCT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B39,108,500 - 39,162,817 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B24,025,383 - 24,079,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B139,855,600 - 139,908,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B139,855,605 - 139,908,764 (-)Ensemblpanpan1.1panPan2
LCT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382135,787,850 - 135,837,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2135,787,850 - 135,837,184 (-)EnsemblGRCh38hg38GRCh38
GRCh372136,545,420 - 136,594,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,261,885 - 136,311,220 (-)NCBINCBI36Build 36hg18NCBI36
Build 342136,379,146 - 136,428,482NCBI
Celera2130,256,175 - 130,305,504 (-)NCBICelera
Cytogenetic Map2q21.3NCBI
HuRef2128,538,586 - 128,587,979 (-)NCBIHuRef
CHM1_12136,550,605 - 136,600,149 (-)NCBICHM1_1
T2T-CHM13v2.02136,228,325 - 136,281,636 (-)NCBIT2T-CHM13v2.0
Lct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391128,212,493 - 128,256,055 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1128,212,493 - 128,256,055 (-)EnsemblGRCm39 Ensembl
GRCm381128,284,756 - 128,328,318 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1128,284,756 - 128,328,318 (-)EnsemblGRCm38mm10GRCm38
MGSCv371130,181,341 - 130,224,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,112,310 - 130,155,864 (-)NCBIMGSCv36mm8
Celera1130,912,375 - 130,955,221 (-)NCBICelera
Cytogenetic Map1E3NCBI
cM Map155.8NCBI
Lct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21339,781,929 - 39,824,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,781,929 - 39,824,456 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,375,821 - 42,418,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01343,663,926 - 43,706,446 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01340,917,951 - 40,960,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01344,998,414 - 45,040,593 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1344,998,414 - 45,040,593 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,083,769 - 50,125,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41340,990,315 - 41,043,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,017,068 - 41,018,494 (-)NCBI
Celera1340,155,673 - 40,198,507 (-)NCBICelera
Cytogenetic Map13q13NCBI
Lct
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554403,148,730 - 3,197,110 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554403,148,730 - 3,197,110 (-)NCBIChiLan1.0ChiLan1.0
LCT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11938,571,539 - 38,620,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1938,572,058 - 38,620,567 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1938,812,141 - 38,863,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01940,014,481 - 40,065,894 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1940,017,274 - 40,065,921 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11938,656,504 - 38,707,872 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01938,815,944 - 38,867,284 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01940,048,815 - 40,100,194 (-)NCBIUU_Cfam_GSD_1.0
Lct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303101,510,063 - 101,552,920 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646940,064,822 - 40,107,447 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646940,064,822 - 40,108,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100625897
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11516,094,277 - 16,154,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21518,486,673 - 18,544,563 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11019,994,398 - 20,049,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1019,994,384 - 20,049,097 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660612,414,641 - 2,469,654 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lct
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473235,125,287 - 35,175,062 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473235,125,995 - 35,177,055 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003822810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000005436   ⟹   ENSPPAP00000001152
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B139,855,605 - 139,908,764 (-)Ensembl
RefSeq Acc Id: XM_003822810   ⟹   XP_003822858
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan12B39,108,500 - 39,162,817 (+)NCBI
Mhudiblu_PPA_v02B24,025,383 - 24,079,779 (+)NCBI
PanPan1.12B139,855,600 - 139,908,764 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003822858 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000001152.1
RefSeq Acc Id: XP_003822858   ⟸   XM_003822810
- UniProtKB: A0A2R8Z8C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000001152   ⟸   ENSPPAT00000005436


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000005000 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000005436.1 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/TrEMBL
InterPro Glyco_hydro_1 UniProtKB/TrEMBL
  Glyco_hydro_1_AS UniProtKB/TrEMBL
  Glyco_hydro_1_N_CS UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
KEGG Report pps:100993974 UniProtKB/TrEMBL
NCBI Gene LCT ENTREZGENE
PANTHER LACTASE-LIKE PROTEIN UniProtKB/TrEMBL
  PTHR10353 UniProtKB/TrEMBL
Pfam Glyco_hydro_1 UniProtKB/TrEMBL
PRINTS GLHYDRLASE1 UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F1_1 UniProtKB/TrEMBL
  GLYCOSYL_HYDROL_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt A0A2R8Z8C5 ENTREZGENE, UniProtKB/TrEMBL