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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartic-type endopeptidase activity
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Accession:GO:0004190 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
Synonyms:exact_synonym: aspartic endopeptidase activity
 narrow_synonym: aspartate protease activity;   aspartic protease activity;   aspartyl protease activity;   carboxyl protease activity
 xref: EC:3.4.23;   reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1";   reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2";   reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants";   reactome:R-HSA-373705 "Caspase cleavage of DCC";   reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3";   reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3";   reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4"

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aspartic-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asprv1 aspartic peptidase retroviral like 1 enables ISO (PMID:16098038)
(MGI:3694389|PMID:16837463)		 UniProt PMID:16098038 PMID:16837463 MGI:3694389 NCBI chrNW_004955424:15,190,746...15,193,270 JBrowse link
G Bace1 beta-secretase 1 enables ISO (PMID:10531052)
(PMID:25592972)
(MGI:6316502|PMID:29325091)		 UniProt
MGI		 PMID:10531052 PMID:25592972 PMID:29325091 MGI:6316502 NCBI chrNW_004955412:18,596,643...18,620,089
Ensembl chrNW_004955412:18,596,643...18,620,362 		JBrowse link
G Bace2 beta-secretase 2 enables ISO (PMID:10591213) UniProt PMID:10591213 NCBI chrNW_004955407:40,792,089...40,879,872
Ensembl chrNW_004955407:40,792,887...40,874,760 		JBrowse link
G Casp3 caspase 3 enables ISO (PMID:15231831), (PMID:23727203) MGI PMID:15231831 PMID:23727203 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Casp7 caspase 7 enables ISO (MGI:7327228|PMID:35705808), (PMID:15231831) MGI PMID:15231831 PMID:35705808 MGI:7327228 NCBI chrNW_004955431:18,685,408...18,723,221
Ensembl chrNW_004955431:18,686,190...18,723,524 		JBrowse link
G Ctsd cathepsin D enables ISO (PMID:19293336) MGI PMID:19293336 NCBI chrNW_004955422:13,576,315...13,584,267
Ensembl chrNW_004955422:13,576,202...13,584,298 		JBrowse link
G Ctse cathepsin E enables ISO (PMID:7789521)
(MGI:87708|PMID:9180269)
PMID:8157122		 UniProt PMID:7789521 PMID:8157122 PMID:9180269 MGI:87708 RGD:8554034 NCBI chrNW_004955406:41,641,412...41,653,261
Ensembl chrNW_004955406:41,641,311...41,653,296 		JBrowse link
G Ddi2 DNA damage inducible 1 homolog 2 enables ISO (PMID:27528193) UniProt PMID:27528193 NCBI chrNW_004955527:2,498,211...2,534,768 JBrowse link
G Pgc progastricsin enables ISO (PMID:12759353) UniProt PMID:12759353 NCBI chrNW_004955437:8,142,523...8,153,044
Ensembl chrNW_004955437:8,142,661...8,151,339 		JBrowse link
G Psen1 presenilin 1 enables ISO (PMID:12684521) MGI PMID:12684521 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737 		JBrowse link
G Ren renin enables ISO (PMID:12045255), (PMID:4289389), (PMID:4322712), (PMID:4330891), (PMID:4360430)
(PMID:12045255), (PMID:20927107)		 Reactome
UniProt		 PMID:4289389 PMID:4322712 PMID:4330891 PMID:4360430 PMID:12045255 More... NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286 		JBrowse link
G Sppl2c signal peptide peptidase like 2C enables ISO (PMID:30733280) UniProt PMID:30733280 NCBI chrNW_004955478:10,368,379...10,370,624
Ensembl chrNW_004955478:10,365,857...10,370,548 		JBrowse link
aspartic endopeptidase activity, intramembrane cleaving term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 enables ISO (PMID:25239945)
(PMID:16873890)		 UniProt PMID:16873890 PMID:25239945 NCBI chrNW_004955422:29,365,722...29,408,788
Ensembl chrNW_004955422:29,362,724...29,408,840 		JBrowse link
G Ncstn nicastrin contributes_to ISO (PMID:16371134) MGI PMID:16371134 NCBI chrNW_004955468:12,111,078...12,126,404
Ensembl chrNW_004955468:12,111,078...12,127,033 		JBrowse link
G Psen1 presenilin 1 enables
contributes_to		 ISO (PMID:26280335)
(PMID:16371134)
(PMID:21206757)
(PMID:17428795)		 UniProt
MGI		 PMID:16371134 PMID:17428795 PMID:21206757 PMID:26280335 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737 		JBrowse link
G Psen2 presenilin 2 enables ISO (PMID:21206757)
(PMID:12684521)		 MGI PMID:12684521 PMID:21206757 NCBI chrNW_004955406:5,727,367...5,748,798
Ensembl chrNW_004955406:5,727,367...5,752,234 		JBrowse link
G Sppl2a signal peptide peptidase like 2A enables ISO (PMID:2313285) UniProt PMID:2313285 NCBI chrNW_004955409:3,642,113...3,670,779
Ensembl chrNW_004955409:3,645,555...3,670,551 		JBrowse link
G Sppl2b signal peptide peptidase like 2B enables
NOT|enables		 ISO (PMID:19114711), (PMID:22194595)
(PMID:2313285)
(PMID:16873890)		 UniProt PMID:2313285 PMID:16873890 PMID:19114711 PMID:22194595 NCBI chrNW_004955495:5,816,979...5,829,938
Ensembl chrNW_004955495:5,818,337...5,829,889 		JBrowse link
G Sppl2c signal peptide peptidase like 2C enables ISO (MGI:6281843|PMID:30733280), (MGI:7332329|PMID:35960805), (MGI:7387163|PMID:30733281) UniProt PMID:30733280 PMID:30733281 PMID:35960805 MGI:6281843 MGI:7332329 MGI:7387163 NCBI chrNW_004955478:10,368,379...10,370,624
Ensembl chrNW_004955478:10,365,857...10,370,548 		JBrowse link
G Sppl3 signal peptide peptidase like 3 enables ISO (PMID:2313285)
(PMID:16873890)		 UniProt PMID:2313285 PMID:16873890 NCBI chrNW_004955455:10,849,627...10,905,515
Ensembl chrNW_004955455:10,760,804...10,907,024 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14225
    catalytic activity 3723
      hydrolase activity 1338
        peptidase activity 354
          endopeptidase activity 182
            aspartic-type endopeptidase activity 18
              aspartic endopeptidase activity, intramembrane cleaving 8
              aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 0
paths to the root