Sppl2c (signal peptide peptidase like 2C)

Gene: Sppl2c (signal peptide peptidase like 2C) Chinchilla lanigera

Analyze

Symbol:

Sppl2c

Name:

signal peptide peptidase like 2C

RGD ID:

8973198

Description:

ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (ortholog); aspartic-type endopeptidase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN acrosome assembly (ortholog); fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); intracellular calcium ion homeostasis (ortholog); ASSOCIATED WITH frontotemporal dementia (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasmic side of endoplasmic reticulum membrane (ortholog); endoplasmic reticulum membrane (ortholog); lumenal side of endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

signal peptide peptidase-like 2C

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	10,365,857 - 10,370,548 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955478	10,368,379 - 10,370,624 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

frontotemporal dementia (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Koolen de Vries syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acrosome assembly (ISO)

fusion of sperm to egg plasma membrane involved in single fertilization (ISO)

intracellular calcium ion homeostasis (ISO)

membrane protein ectodomain proteolysis (ISO)

membrane protein intracellular domain proteolysis (ISO)

protein stabilization (ISO)

spermatogenesis (ISO)

Cellular Component

cytoplasmic side of endoplasmic reticulum membrane (ISO)

endoplasmic reticulum membrane (ISO)

lumenal side of endoplasmic reticulum membrane (ISO)

Molecular Function

aspartic endopeptidase activity, intramembrane cleaving (ISO)

aspartic-type endopeptidase activity (ISO)

molecular adaptor activity (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Sppl2c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	10,365,857 - 10,370,548 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955478	10,368,379 - 10,370,624 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPPL2C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	45,844,881 - 45,847,067 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	45,844,881 - 45,847,067 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	43,922,247 - 43,924,433 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	41,278,053 - 41,280,107 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	40,569,532 - 40,571,714 (+)	NCBI		Celera
Cytogenetic Map	17	q21.31	NCBI
HuRef	17	39,586,040 - 39,588,222 (+)	NCBI		HuRef
CHM1_1	17	44,169,089 - 44,171,271 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	46,706,505 - 46,708,691 (+)	NCBI		T2T-CHM13v2.0

Sppl2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	104,077,153 - 104,081,992 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	104,077,153 - 104,081,989 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	104,186,327 - 104,191,166 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	104,186,327 - 104,191,163 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	104,047,641 - 104,052,480 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	104,002,417 - 104,004,641 (+)	NCBI		MGSCv36	mm8
Celera	11	115,902,689 - 115,907,557 (+)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	67.79	NCBI

Sppl2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	89,595,265 - 89,597,470 (+)	NCBI		GRCr8
mRatBN7.2	10	89,095,279 - 89,097,487 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	89,095,261 - 89,098,580 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	94,132,197 - 94,134,402 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	93,595,711 - 93,597,916 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	88,990,706 - 88,992,911 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	92,245,434 - 92,248,758 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	92,245,442 - 92,248,756 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	92,007,186 - 92,010,510 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	93,367,712 - 93,369,942 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	87,789,420 - 87,791,650 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

SPPL2C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	18,837,498 - 18,843,586 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	20,801,455 - 20,805,016 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	11,323,494 - 11,325,924 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	11,637,769 - 11,640,000 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	11,637,880 - 11,639,934 (-)	Ensembl	panpan1.1		panPan2

SPPL2C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	9,703,119 - 9,705,300 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	9,703,230 - 9,705,212 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	10,592,687 - 10,594,864 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	11,295,097 - 11,297,275 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	11,295,208 - 11,297,190 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	10,305,832 - 10,308,011 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	17,213,742 - 17,215,919 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	17,162,747 - 17,164,925 (+)	NCBI		UU_Cfam_GSD_1.0

Sppl2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	16,852,112 - 16,854,374 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	2,340,302 - 2,343,247 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	2,340,302 - 2,342,380 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPPL2C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	17,240,736 - 17,242,823 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	17,238,339 - 17,245,060 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	17,354,773 - 17,357,520 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPPL2C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	60,059,144 - 60,062,178 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666077	30,781,471 - 30,783,526 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sppl2c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624849	2,468,699 - 2,471,428 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624849	2,469,076 - 2,471,365 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005402268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01056132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01008849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000009941 ⟹ ENSCLAP00000009812

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955478	10,365,857 - 10,370,548 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000009942 ⟹ ENSCLAP00000009813

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955478	10,368,485 - 10,370,548 (-)	Ensembl

RefSeq Acc Id:

XM_005402268 ⟹ XP_005402325

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955478	10,368,379 - 10,370,624 (-)	NCBI

Sequence:

show sequence

GCCACACCCACCCCAGGGAGGAGAGCCCACTGCGGGCCGCTGCCCCTTGGGGTCATACAGCAGG
CGGCTGAGGGGGATGGCGTGCCTGGGCTTCCTCCTCCCTGTGGCCTTGCTGCTCCTCCTCGTCA
GCGCCGTGGCCCAGGGGAAGCACGGCGTGGTCCACGTGGTGTCGGATACCTGGAGCAAAGACTA
TTGCATCCTGTTCAGCTCCGACTATGTCACCCTGCCCCGGGACCTGCGCCACGCCCCACTCCTG
CCCCTGCACGACGGCACCAAGGCATCCTGGTGCCCAGGCGAGGACTCCTTCCAACAGGCCCGGC
CCCGCTCCTCCAGACCGCAGCCCCTTCGCCACACCACCGCCATGGCCATGAGGGGCAACTGCAG
CTTCCACGCCAAGGGCTGGCTGGCTCAGGGCCGAGGAGCCCACGGGCTGCTCATCGTGAGCAGG
GTCAGCGAGCAGCACTGCTCAGACACCAGCTCGGTGTCCCAGGACCCCCGCCGGCCCCTGCCCG
ACCTCGCCATCCCTGTGGCTGTGCTTCGCTACACAGACATGCTGGACATCGTCAGGCACACGCA
CGGAGCCGCCACCGTCCGCGTGGCCATGTACGCACCCCCAGAGCCCATCATCGACTACAACCTG
GTGGTCATCTTTGTCCTGGCCGTGGGCACCGTGGCGGTGGGTGGGTACTGGGCCGGGCTGATGG
AGGCCGCCTGGCTGCAGCGGCGCCGGGCCCGGGGAGGAGGGGGGCCTGACGGCCACCCGGCAGC
GGCAGCGGAGGGGCCAGCAGGGCTCCACGAGGATGCAAATGACGAGGACTCTGCAGTGAACTTC
ACGCTGGCCGTCGCAGGCGCCGTGGTCACCATGTCCTGCTCCATCGTGGTTTTGCTCTACTTCT
TCTACGACTACTTTGTCTATGTCATGATTGGGATCTTTGGCCTGGGTGCTGGCACCGGCCTCTA
CAGCTGCCTGGCGCCCCTGGTGCACCACCTGCCGCTGCAGCGCTATCAGTGGCCCCTCCCTGGC
CACCGGGCCCACCTGCAGCTGCCCCAGCTGCTGCTGGCGGGCCTGTGCACCCTGGTGACCCTCC
TCTGGGTCACCTGCCGCAATGAGGACCGCTGGGCGTGGCTTCTGCAGGACATGCTGGGCATAGC
TTACTGCCTCTTCGTCCTGCGGCGAGTACGGCTGCCCACACTCAAGAACTGCACCTGCTTCCTG
CTGGTCCTGCTGGCCTTTGACGTCTTTTTCGTCTTCATCACACCCCTCTTCACCAAGACCGGTG
ACAGTATCATGCTGGAGATCGCCTCTGGCCCAGCAGGTTCCTCGAGCCACGAGAAGCTGCCCAT
GGTGCTCAAAGTGCCCCGGCTACGTGCCTCGGCCTTGACGCCCTGCGACCAGCCCTTCTCCATC
CTCGGCTTTGGTGATATTGTGGTCCCTGGCTTCCTGGTTGCCTACTGTCACCGCTTTGACGTGC
ACGTCCACTCTTATCCGGTCTACTTTGTGGCCTGCACCGTGGCCTACGCCCTGGGCCTGATGAT
CACCTTCTTGGCCATGGTTCTCATGGAGATGGGCCAGCCCGCCCTGCTCTACTTAGTGTCCAGC
ACCCTGCTCACCAGCCTTGCCGTGGCCGCCTACCGTCAAGAGCTCACCCTCTTCTGGACGGGCC
GGAGCAGAGCTCAGACACCTGCTCAGCCCGTGGCAGAGCTCTGTGCTGTCCCTGAGGACTGCTC
CGAGCAGAGACAGGAGGGCACGGCAGAGGGCCACACAGCCAGTGAGTTGGAGGGGGCCGCTGAC
CAGGGGGCAGGGGACTTGGACAGCAACTCTGGGGAGGACACGGGTGACATGGTCACCATATCCG
AGGATGAAGTCACCAGTCAGGGGGGCCACAGTGAGAACTCTGAGGCCTGGAGTGATGCCAACCT
GGATCCTGATGACCTGCCCCCTGCCTCCTCCGCAGCTGCAGAGGACCTGCAGCCACTGATGCCA
GCAGCCCTGTGGGTCCCGCTGATGCCTCCGCCCTCAGAGCTGGGCCACATCCATACTCAGGCCC
AGGCCCAGGAGGCCAGCCTCCCCCGGACAGGGCTCCACAGGAGGAGGGGCTGGAAAGTGAAGAA
CAGTGTGTCGGCGCAGGCTTTCCTGTGAGCCAGAGCCCCGGGGACCTGTGCCTCCGAGAGGGCC
GGCGCAGCACCGCAGAGCAAAGCACATGCGGTGGGAAAGATTGGGATGAAGGAGAAACTCCGTA
ACTAGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005402325	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000009812.1
	ENSCLAP00000009813.1

RefSeq Acc Id:

XP_005402325 ⟸ XM_005402268

- UniProtKB:

A0A8C2V3P0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MACLGFLLPVALLLLLVSAVAQGKHGVVHVVSDTWSKDYCILFSSDYVTLPRDLRHAPLLPLHD
GTKASWCPGEDSFQQARPRSSRPQPLRHTTAMAMRGNCSFHAKGWLAQGRGAHGLLIVSRVSEQ
HCSDTSSVSQDPRRPLPDLAIPVAVLRYTDMLDIVRHTHGAATVRVAMYAPPEPIIDYNLVVIF
VLAVGTVAVGGYWAGLMEAAWLQRRRARGGGGPDGHPAAAAEGPAGLHEDANDEDSAVNFTLAV
AGAVVTMSCSIVVLLYFFYDYFVYVMIGIFGLGAGTGLYSCLAPLVHHLPLQRYQWPLPGHRAH
LQLPQLLLAGLCTLVTLLWVTCRNEDRWAWLLQDMLGIAYCLFVLRRVRLPTLKNCTCFLLVLL
AFDVFFVFITPLFTKTGDSIMLEIASGPAGSSSHEKLPMVLKVPRLRASALTPCDQPFSILGFG
DIVVPGFLVAYCHRFDVHVHSYPVYFVACTVAYALGLMITFLAMVLMEMGQPALLYLVSSTLLT
SLAVAAYRQELTLFWTGRSRAQTPAQPVAELCAVPEDCSEQRQEGTAEGHTASELEGAADQGAG
DLDSNSGEDTGDMVTISEDEVTSQGGHSENSEAWSDANLDPDDLPPASSAAAEDLQPLMPAALW
VPLMPPPSELGHIHTQAQAQEASLPRTGLHRRRGWKVKNSVSAQAFL

hide sequence

RefSeq Acc Id:

ENSCLAP00000009813 ⟸ ENSCLAT00000009942

RefSeq Acc Id:

ENSCLAP00000009812 ⟸ ENSCLAT00000009941

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000006798	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000009941.1	UniProtKB/TrEMBL
	ENSCLAT00000009942.1	UniProtKB/TrEMBL
Gene3D-CATH	3.50.30.30	UniProtKB/TrEMBL
InterPro	Peptidase_A22B_SPP	UniProtKB/TrEMBL
	Preselin/SPP	UniProtKB/TrEMBL
NCBI Gene	Sppl2c	ENTREZGENE
PANTHER	PTHR12174	UniProtKB/TrEMBL
	PTHR12174:SF38	UniProtKB/TrEMBL
Pfam	Peptidase_A22B	UniProtKB/TrEMBL
SMART	PSN	UniProtKB/TrEMBL
UniProt	A0A8C2V3P0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2V8S9_CHILA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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