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Gene: SPPL2C (signal peptide peptidase like 2C) Homo sapiens
Symbol: SPPL2C
Name: signal peptide peptidase like 2C
Description: Exhibits protein homodimerization activity. Predicted to be involved in membrane protein proteolysis. Localizes to the integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane; INTERACTS WITH arsenous acid; carbamazepine; diarsenic trioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IMP-5; IMP5; intramembrane protease 5; signal peptide peptidase-like 2C; SPP-like 2C
Mus musculus (house mouse) : Sppl2c (signal peptide peptidase 2C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sppl2c (signal peptide peptidase like 2C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sppl2c (signal peptide peptidase like 2C)
Pan paniscus (bonobo/pygmy chimpanzee) : SPPL2C (signal peptide peptidase like 2C)
Canis lupus familiaris (dog) : SPPL2C (signal peptide peptidase like 2C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sppl2c (signal peptide peptidase like 2C)
Sus scrofa (pig) : SPPL2C (signal peptide peptidase like 2C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381745,844,881 - 45,847,067 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371743,922,256 - 43,924,438 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361741,278,053 - 41,280,107 (+)NCBINCBI36hg18NCBI36
Celera1740,569,532 - 40,571,714 (+)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1739,586,040 - 39,588,222 (+)NCBIHuRef
CHM1_11744,169,089 - 44,171,271 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPPL2C
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606947
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.