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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Klatskin's tumor
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Accession:DOID:4927 term browser browse the term
Definition:An intrahepatic cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts. (DO)
Synonyms:exact_synonym: Klatskin tumor;   Klatskin tumour;   Klatskin's tumour;   Klatskins tumor;   hilar cholangiocarcinoma;   hilar cholangiocarcinomas;   hilar cholangiocellular carcinoma;   perihilar cholangiocarcinoma;   perihilar extrahepatic bile duct carcinoma
 primary_id: MESH:D018285
 alt_id: DOID:5246
 xref: EFO:1001005;   EFO:1001959;   GARD:10175;   NCI:C36077;   ORDO:99978
For additional species annotation, visit the Alliance of Genome Resources.


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Klatskin's tumor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Klatskin tumor ClinVar PMID:25741868 PMID:28492532 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Arid1a AT-rich interaction domain 1A disease_progression ISO DNA:deletions RGD PMID:33387086 RGD:126848756 NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564 		JBrowse link
G Gata6 GATA binding protein 6 sexual_dimorphism ISO DNA:mutations RGD PMID:33387086 RGD:126848756 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Kmt2c lysine methyltransferase 2C onset ISO DNA:mutations RGD PMID:33387086 RGD:126848756 NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539 		JBrowse link
G Kras KRAS proto-oncogene, GTPase disease_progression ISO DNA:mutations RGD PMID:33387086 RGD:126848756 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 sexual_dimorphism ISO DNA:substitutions, insertion/deletions: (human) RGD PMID:33387086 PMID:33387086 RGD:126848756, RGD:126848756 NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    disease of cellular proliferation 7692
      Neoplasms by Histologic Type 5288
        Glandular and Epithelial Neoplasms 3738
          carcinoma 3201
            adenocarcinoma 1713
              bile duct adenocarcinoma 140
                cholangiocarcinoma 140
                  intrahepatic cholangiocarcinoma 32
                    Klatskin's tumor 6
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      gastrointestinal system disease 7096
        Digestive System Neoplasms 3836
          Gastrointestinal Neoplasms 3711
            gastrointestinal system benign neoplasm 236
              hepatobiliary benign neoplasm 184
                biliary tract benign neoplasm 155
                  Bile Duct Neoplasms 152
                    bile duct cancer 150
                      bile duct carcinoma 140
                        bile duct adenocarcinoma 140
                          cholangiocarcinoma 140
                            intrahepatic cholangiocarcinoma 32
                              Klatskin's tumor 6
paths to the root