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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:thyroid gland adenocarcinoma
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Accession:DOID:0080524 term browser browse the term
Definition:A thyroid gland carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms:xref: NCI:C27380


show annotations for term's descendants           Sort by:
follicular thyroid carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRAF B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:12068308 PMID:12198537 PMID:12960123 PMID:14679157 PMID:15035987 More... NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More... NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27440272 NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335 		JBrowse link
G LRRC56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More... NCBI chr11:514,227...559,838
Ensembl chr11:575,495...588,750 		JBrowse link
G NRAS NRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More... NCBI chr 1:87,837,146...87,850,013
Ensembl chr 1:122,890,505...122,903,585 		JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha ISO OMIM:188470 MouseDO NCBI chr17:62,448,718...62,488,493
Ensembl chr17:67,838,484...67,877,943 		JBrowse link
G PTEN phosphatase and tensin homolog ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:24033266 PMID:24055113 PMID:25741868 PMID:25980754 PMID:28492532 More... NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 ISO ClinVar Annotator: match by term: THYROID CARCINOMA, FOLLICULAR ClinVar PMID:23539728 NCBI chr12:24,760,093...25,066,794
Ensembl chr12:25,262,893...25,564,180 		JBrowse link
G THRB thyroid hormone receptor beta ISO CTD Direct Evidence: marker/mechanism
OMIM:188470		 CTD
MouseDO		 PMID:27440272 NCBI chr 3:24,024,025...24,401,024
Ensembl chr 3:24,346,824...24,564,960 		JBrowse link
oncocytic carcinoma of the thyroid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBX7 chromobox 7 ISO protein:decreased expression:thyroid Human) RGD PMID:25759796 RGD:11352710 NCBI chr22:20,037,529...20,059,459
Ensembl chr22:37,854,056...37,876,084 		JBrowse link
G PSMB9 proteasome 20S subunit beta 9 ISO RGD PMID:19924240 RGD:6483332 NCBI chr 6:32,423,614...32,429,062
Ensembl chr 6:33,539,060...33,564,402 		JBrowse link
papillary thyroid carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase susceptibility ISO associated with Radiation-Induced Neoplasms;DNA:SNPs,haplotypes:exon 39,intron 22,intron 48: p.D1853N, IVS22-77 T>C, IVS48 + 238 C>G (rs1801516, rs664677, rs609429)
ClinVar Annotator: match by term: Papillary thyroid carcinoma		 RGD
ClinVar		 PMID:19286843 PMID:19404735 PMID:20305132 PMID:23555315 PMID:25085752 More... RGD:401850780 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041 		JBrowse link
G BEGAIN brain enriched guanylate kinase associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr14:81,157,642...81,209,503
Ensembl chr14:100,471,969...100,512,416 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase onset ISO DNA:mutation:cds:p.V600E(human)
ClinVar Annotator: match by term: Papillary thyroid carcinoma		 RGD
ClinVar		 PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 PMID:12460919 More... RGD:7241798 NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115 		JBrowse link
G BRD4 bromodomain containing 4 ISO mRNA, protein:increased expression:thyroid RGD PMID:26707881 RGD:11085509 NCBI chr19:14,768,239...14,805,770
Ensembl chr19:15,754,930...15,789,600 		JBrowse link
G C9H11orf65 chromosome 9 C11orf65 homolog ISO ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:19404735 PMID:20305132 PMID:23555315 PMID:25085752 PMID:25186627 More... NCBI chr11:103,195,244...103,352,211
Ensembl chr11:106,670,277...106,817,886 		JBrowse link
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO mRNA:increased expression:thyroid gland RGD PMID:23569218 RGD:18337285 NCBI chr 1:19,437,761...19,441,573
Ensembl chr 1:20,479,562...20,482,600 		JBrowse link
G CAT catalase ISO protein:increased activity:plasma: RGD PMID:20204550 RGD:9068926 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CBX7 chromobox 7 ISO mRNA,protein,DNA:decreased expression, loss of heterozygosity:thyroid gland:
mRNA:decreased expression:thyroid gland (mouse)		 RGD PMID:18701502 RGD:9587357 NCBI chr22:20,037,529...20,059,459
Ensembl chr22:37,854,056...37,876,084 		JBrowse link
G CCDC6 coiled-coil domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr10:56,322,619...56,440,410
Ensembl chr10:58,537,553...58,655,454 		JBrowse link
G CCND1 cyclin D1 ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr11:64,737,006...64,750,353 JBrowse link
G CDH1 cadherin 1 ISO DNA:hypermethylation:promoter RGD PMID:25520863 RGD:13792554 NCBI chr16:49,108,745...49,206,347
Ensembl chr16:68,502,584...68,596,488 		JBrowse link
G CTNNB1 catenin beta 1 disease_progression ISO mRNA:increased expression:thyroid RGD PMID:28677753 PMID:29498921 RGD:13792558 RGD:13792605 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030 		JBrowse link
G DIO3 iodothyronine deiodinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr14:82,188,126...82,190,220 JBrowse link
G DYNC1H1 dynein cytoplasmic 1 heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr14:82,584,876...82,670,750
Ensembl chr14:102,406,993...102,489,475 		JBrowse link
G KMT2D lysine methyltransferase 2D ISO associated with familial adenomatous polyposis;DNA:missense mutations, nonsense mutation RGD PMID:32024448 RGD:150523759 NCBI chr12:39,689,463...39,731,904
Ensembl chr12:40,575,083...40,608,661 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr 4:100,552,959...100,674,156
Ensembl chr 4:111,125,312...111,245,980 		JBrowse link
G LIG4 DNA ligase 4 ISO ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:25741868 NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555 		JBrowse link
G LOC100977130 tropomyosin alpha-3 chain ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr 1:129,511,914...129,538,703
Ensembl chr 1:133,126,641...133,161,894 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863 		JBrowse link
G NKX2-1 NK2 homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD
G PALB2 partner and localizer of BRCA2 ISO ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:25741868 PMID:28492532 NCBI chr16:14,470,367...14,507,841
Ensembl chr16:23,855,535...23,892,117 		JBrowse link
G PLAU plasminogen activator, urokinase severity ISO mRNA:increased expression:thyroid gland (human) RGD PMID:22702340 RGD:7241798 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr14:82,383,086...82,549,822
Ensembl chr14:102,206,396...102,372,978 		JBrowse link
G RAP1GAP RAP1 GTPase activating protein ISO protein:decreased expression:thyroid gland (human) RGD PMID:19066305 RGD:9835342 NCBI chr 1:20,790,076...20,860,511
Ensembl chr 1:21,754,733...21,824,405 		JBrowse link
G RET ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr10:40,050,396...40,103,629
Ensembl chr10:43,249,468...43,284,331 		JBrowse link
G RUNX3 RUNX family transcription factor 3 ISO DNA:hypermethylation:promoter RGD PMID:25520863 RGD:13792554 NCBI chr 1:24,097,321...24,164,065
Ensembl chr 1:25,073,134...25,137,335 		JBrowse link
G RXRG retinoid X receptor gamma ISO mRNA:increased expression:thyroid RGD PMID:28677753 RGD:13792605 NCBI chr 1:140,832,717...140,877,046
Ensembl chr 1:144,623,133...144,723,494 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr20:46,321,075...46,328,865
Ensembl chr20:47,384,818...47,390,733 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr 8:45,341,857...45,345,544
Ensembl chr 8:42,723,971...42,730,904 		JBrowse link
G TP53 tumor protein p53 susceptibility ISO associated with Radiation-Induced Neoplasms;DNA:SNPs, haplotypes:exon 4: p.R72P (rs1042522) (human) RGD PMID:19286843 RGD:401850780 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
G WARS1 tryptophanyl-tRNA synthetase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr14:80,954,852...80,996,316
Ensembl chr14:100,268,845...100,310,662 		JBrowse link
G WDR20 WD repeat domain 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr14:82,759,715...82,843,491
Ensembl chr14:102,577,138...102,660,459 		JBrowse link
G WDR3 WD repeat domain 3 susceptibility ISO DNA:snps, haplotype:introns: c.500+239G>A, c.*1-2382A>C (rs3765501, rs4658973) (human) RGD PMID:20578902 RGD:11041898 NCBI chr 1:84,561,424...84,595,602
Ensembl chr 1:119,560,287...119,590,508 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP:exon 10: p.R399Q (rs25487) (Human) RGD PMID:19286843 RGD:401850780 NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520 		JBrowse link
G ZEB1 zinc finger E-box binding homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr10:31,449,202...31,659,534
Ensembl chr10:32,046,491...32,253,550 		JBrowse link
G ZEB2 zinc finger E-box binding homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28030816 NCBI chr2B:15,325,094...15,460,908
Ensembl chr2B:148,460,904...148,596,500 		JBrowse link
Thyroid Cancer, Nonmedullary, 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXE1 forkhead box E1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 4 OMIM
ClinVar		 PMID:25381600 PMID:25741868 PMID:28444304 PMID:32428920 NCBI chr 9:68,943,747...68,947,226 JBrowse link
Thyroid Cancer, Nonmedullary, 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HABP2 hyaluronan binding protein 2 ISO ClinVar Annotator: match by term: HABP2-related condition | ClinVar Annotator: match by term: THYROID CANCER, NONMEDULLARY, 5, SUSCEPTIBILITY TO | ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 5 ClinVar
OMIM		 PMID:12138371 PMID:12578864 PMID:15486068 PMID:25741868 PMID:26222560 More... NCBI chr10:110,146,311...110,182,871
Ensembl chr10:113,580,321...113,616,810 		JBrowse link
Thyroid Carcinoma, Nonmedullary 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KRAS KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335 		JBrowse link
G NKX2-1 NK2 homeobox 1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar
OMIM		 PMID:19176457 PMID:25741868 PMID:28492532
G PCM1 pericentriolar material 1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar PMID:10980597 PMID:25741868 NCBI chr 8:17,140,458...17,246,165
Ensembl chr 8:14,093,988...14,199,691 		JBrowse link
G RINT1 RAD50 interactor 1 ISO ClinVar Annotator: match by term: Thyroid cancer, nonmedullary, 1 ClinVar PMID:16199547 PMID:25741868 PMID:28492532 PMID:31204009 PMID:33471991 NCBI chr 7:97,522,208...97,567,897
Ensembl chr 7:110,252,776...110,287,702 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15811
    disease of cellular proliferation 7490
      cancer 5522
        cell type cancer 3700
          carcinoma 3138
            adenocarcinoma 1588
              thyroid gland adenocarcinoma 49
                differentiated high-grade thyroid carcinoma + 49
Path 2
Term Annotations click to browse term
  disease 15811
    disease of cellular proliferation 7490
      cancer 5522
        organ system cancer 5293
          endocrine gland cancer 2509
            thyroid cancer 74
              thyroid gland carcinoma 67
                thyroid gland adenocarcinoma 49
                  differentiated high-grade thyroid carcinoma + 49
paths to the root