SNAI2 (snail family transcriptional repressor 2) - Rat Genome Database

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Gene: SNAI2 (snail family transcriptional repressor 2) Pan paniscus
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Symbol: SNAI2
Name: snail family transcriptional repressor 2
RGD ID: 11866175
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cartilage morphogenesis (ortholog); cell migration involved in endocardial cushion formation (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); calcinosis (ortholog); Esophageal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: snail homolog 2; zinc finger protein SNAI2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2764,549,281 - 64,553,640 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1840,242,786 - 40,246,461 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0845,341,857 - 45,345,544 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1842,727,135 - 42,730,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl842,723,971 - 42,730,904 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cartilage morphogenesis  (ISO)
cell migration involved in endocardial cushion formation  (ISO)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to ionizing radiation  (ISO)
chromatin organization  (ISO)
desmosome disassembly  (IEA)
endothelial cell migration  (ISO)
epithelial cell migration  (ISO)
epithelial to mesenchymal transition  (IEA,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
epithelium development  (ISO)
hematopoietic stem cell proliferation  (ISO)
myeloid cell apoptotic process  (ISO)
negative regulation of anoikis  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cell adhesion involved in substrate-bound cell migration  (ISO)
negative regulation of cell adhesion mediated by integrin  (IEA,ISO)
negative regulation of chondrocyte differentiation  (IEA)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of hematopoietic stem cell proliferation  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IEA)
negative regulation of keratinocyte proliferation  (IEA)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vitamin D biosynthetic process  (IEA)
negative regulation of vitamin D receptor signaling pathway  (IEA)
neural crest cell development  (IEA)
Notch signaling pathway  (IEA)
osteoblast differentiation  (IEA)
pigmentation  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of fat cell differentiation  (ISO)
regulation of bicellular tight junction assembly  (IEA)
regulation of branching involved in salivary gland morphogenesis  (ISO)
regulation of chemokine production  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of osteoblast differentiation  (IEA)
response to radiation  (ISO)
roof of mouth development  (ISO)
sensory perception of sound  (IEA)
substrate-dependent cell migration  (ISO)
white fat cell differentiation  (ISO)

Cellular Component
chromatin  (IEA)
cytoplasm  (ISO)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SNAI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2764,549,281 - 64,553,640 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1840,242,786 - 40,246,461 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0845,341,857 - 45,345,544 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1842,727,135 - 42,730,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl842,723,971 - 42,730,904 (-)Ensemblpanpan1.1panPan2
SNAI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38848,917,598 - 48,921,429 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl848,917,598 - 48,921,740 (-)EnsemblGRCh38hg38GRCh38
GRCh37849,830,157 - 49,833,988 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36849,992,789 - 49,996,541 (-)NCBINCBI36Build 36hg18NCBI36
Build 34849,992,795 - 49,996,541NCBI
Celera845,817,447 - 45,821,199 (-)NCBICelera
Cytogenetic Map8q11.21NCBI
HuRef845,294,292 - 45,298,055 (-)NCBIHuRef
CHM1_1849,882,550 - 49,886,313 (-)NCBICHM1_1
T2T-CHM13v2.0849,295,468 - 49,299,299 (-)NCBIT2T-CHM13v2.0
Snai2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,523,716 - 14,527,259 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1614,523,716 - 14,527,249 (+)EnsemblGRCm39 Ensembl
GRCm381614,705,852 - 14,709,395 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,705,852 - 14,709,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371614,705,952 - 14,709,478 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361614,619,437 - 14,622,963 (+)NCBIMGSCv36mm8
Celera1615,292,698 - 15,296,242 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map1610.07NCBI
Snai2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81199,686,934 - 99,690,349 (-)NCBIGRCr8
mRatBN7.21186,182,788 - 86,186,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1186,181,909 - 86,186,200 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1194,927,965 - 94,930,275 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01187,586,463 - 87,588,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,642,722 - 86,645,032 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01190,404,421 - 90,406,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1190,403,333 - 90,406,797 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01193,462,645 - 93,464,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1184,915,524 - 84,917,833 (-)NCBICelera
Cytogenetic Map11q23NCBI
Snai2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554548,758,636 - 8,764,427 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554548,759,860 - 8,763,603 (-)NCBIChiLan1.0ChiLan1.0
SNAI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1291,154,132 - 1,156,653 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl291,154,036 - 1,156,653 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha291,580,366 - 1,582,888 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0291,209,732 - 1,213,335 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl291,210,224 - 1,213,476 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1291,151,831 - 1,154,347 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0291,378,544 - 1,381,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0291,416,068 - 1,418,591 (-)NCBIUU_Cfam_GSD_1.0
Snai2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530378,624,121 - 78,627,846 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365903,813,888 - 3,817,642 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365903,813,916 - 3,817,642 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNAI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl479,264,880 - 79,268,475 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1479,264,880 - 79,268,475 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2486,680,198 - 86,683,793 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNAI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1845,043,381 - 45,047,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl845,043,393 - 45,046,978 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603996,972,541 - 96,976,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snai2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247356,594,695 - 6,598,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247356,594,564 - 6,598,288 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000017162   ⟹   ENSPPAP00000003717
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl842,723,971 - 42,730,904 (-)Ensembl
RefSeq Acc Id: XM_003823263   ⟹   XP_003823311
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2764,549,281 - 64,553,640 (-)NCBI
NHGRI_mPanPan1840,242,786 - 40,246,461 (-)NCBI
Mhudiblu_PPA_v0845,341,857 - 45,345,544 (-)NCBI
PanPan1.1842,727,135 - 42,730,736 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063606751   ⟹   XP_063462821
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2764,549,281 - 64,553,287 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003823311 (Get FASTA)   NCBI Sequence Viewer  
  XP_063462821 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000003717
  ENSPPAP00000003717.1
RefSeq Acc Id: XP_003823311   ⟸   XM_003823263
- UniProtKB: A0A2R8ZFE3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000003717   ⟸   ENSPPAT00000017162
RefSeq Acc Id: XP_063462821   ⟸   XM_063606751
- UniProtKB: A0A2R8ZFE3 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000015662 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000017162.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Snail/Krueppel_Znf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report pps:100979404 UniProtKB/TrEMBL
NCBI Gene SNAI2 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN SNAI2 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A2R8ZFE3 ENTREZGENE, UniProtKB/TrEMBL