LEF1 (lymphoid enhancer binding factor 1) - Rat Genome Database

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Gene: LEF1 (lymphoid enhancer binding factor 1) Pan paniscus
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Symbol: LEF1
Name: lymphoid enhancer binding factor 1
RGD ID: 11788749
Description: ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); beta-catenin binding (ortholog); C2H2 zinc finger domain binding (ortholog); INVOLVED IN alpha-beta T cell differentiation (ortholog); anatomical structure regression (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Disease Models (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); Breast Neoplasms (ortholog); FOUND IN beta-catenin-TCF complex (ortholog); cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: lymphoid enhancer-binding factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14111,125,312 - 111,245,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (ISO)
anatomical structure regression  (ISO)
animal organ regeneration  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic process involved in morphogenesis  (ISO)
B cell proliferation  (ISO)
BMP signaling pathway  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell adhesion  (ISO)
cell chemotaxis  (ISO)
cell development  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-4  (ISO)
chorio-allantoic fusion  (ISO)
dentate gyrus development  (ISO)
embryonic limb morphogenesis  (ISO)
epithelial to mesenchymal transition  (ISO)
face morphogenesis  (ISO)
forebrain neuroblast division  (ISO)
forebrain radial glial cell differentiation  (ISO)
formation of radial glial scaffolds  (ISO)
hippocampus development  (ISO)
histone H3 acetylation  (ISO)
histone H3-K56 acetylation  (ISO)
histone H4 acetylation  (ISO)
kidney development  (ISO)
mammary gland development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of interleukin-13 production  (ISO)
negative regulation of interleukin-4 production  (ISO)
negative regulation of interleukin-5 production  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
neutrophil differentiation  (ISO)
odontoblast differentiation  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (ISO)
paraxial mesoderm formation  (ISO)
positive regulation by host of viral transcription  (ISO)
positive regulation of cell cycle process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of chondrocyte proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
regulation of cell-cell adhesion  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
regulation of Wnt signaling pathway  (ISO)
response to lithium ion  (ISO)
response to organic cyclic compound  (ISO)
secondary palate development  (ISO)
sensory perception of taste  (ISO)
skin development  (ISO)
somitogenesis  (ISO)
sprouting angiogenesis  (ISO)
T cell receptor V(D)J recombination  (ISO)
T-helper 1 cell differentiation  (ISO)
tongue development  (ISO)
trachea gland development  (ISO)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14111,125,312 - 111,245,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBIMhudiblu_PPA_v0panPan3
LEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4108,047,545 - 108,168,956 (-)EnsemblGRCh38hg38GRCh38
GRCh384108,047,548 - 108,168,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374108,968,704 - 109,090,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,188,150 - 109,309,027 (-)NCBINCBI36hg18NCBI36
Build 344109,326,304 - 109,447,182NCBI
Celera4106,263,513 - 106,384,975 (-)NCBI
Cytogenetic Map4q25NCBI
HuRef4104,700,344 - 104,821,596 (-)NCBIHuRef
CHM1_14108,945,152 - 109,066,566 (-)NCBICHM1_1
Lef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393130,903,946 - 131,018,006 (+)NCBIGRCm39mm39
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)Ensembl
GRCm383131,110,297 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBImm8
Celera3137,630,007 - 137,744,454 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.78NCBI
Lef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22219,666,549 - 219,779,815 (+)NCBI
Rnor_6.0 Ensembl2236,233,239 - 236,345,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02236,232,115 - 236,345,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02254,781,171 - 254,893,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,550,263 - 228,673,131 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12228,537,002 - 228,659,871 (+)NCBI
Celera2211,924,784 - 212,018,812 (+)NCBICelera
Cytogenetic Map2q43NCBI
Lef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,728,840 - 1,828,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBIChiLan1.0ChiLan1.0
LEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,516,002 - 28,633,759 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,517,108 - 28,634,019 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,389,033 - 13,506,807 (+)NCBI
ROS_Cfam_1.03228,744,891 - 28,862,596 (-)NCBI
UMICH_Zoey_3.13228,737,873 - 28,855,560 (-)NCBI
UNSW_CanFamBas_1.03228,482,671 - 28,600,623 (-)NCBI
UU_Cfam_GSD_1.03211,256,345 - 11,374,064 (+)NCBI
Lef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,484,346 - 12,597,999 (+)NCBI
SpeTri2.0NW_004936818453,635 - 569,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,824,547 - 113,944,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,824,511 - 113,944,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,085,854 - 122,204,415 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEF1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,974,770 - 56,096,214 (-)NCBI
ChlSab1.1 Ensembl755,990,621 - 56,094,110 (-)Ensembl
Vero_WHO_p1.0NW_02366603734,601,310 - 34,723,183 (-)NCBI
Lef1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248301,320,034 - 1,422,774 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000063459   ⟹   ENSPPAP00000040542
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063462   ⟹   ENSPPAP00000040545
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063464   ⟹   ENSPPAP00000040547
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,125,315 - 111,245,980 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063468   ⟹   ENSPPAP00000040551
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,141,171 - 111,243,385 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063469   ⟹   ENSPPAP00000040552
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,145,053 - 111,244,870 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063472   ⟹   ENSPPAP00000040555
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4111,158,854 - 111,243,385 (-)Ensembl
RefSeq Acc Id: XM_003829997   ⟹   XP_003830045
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14111,125,312 - 111,245,980 (-)NCBI
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003829998   ⟹   XP_003830046
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14111,125,312 - 111,245,980 (-)NCBI
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003829999   ⟹   XP_003830047
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14111,125,315 - 111,245,980 (-)NCBI
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955362   ⟹   XP_008953610
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14111,125,315 - 111,245,064 (-)NCBI
Mhudiblu_PPA_v04100,552,962 - 100,672,800 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958980   ⟹   XP_034814871
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v04100,552,962 - 100,671,860 (-)NCBI
RefSeq Acc Id: XM_034958981   ⟹   XP_034814872
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v04100,552,959 - 100,671,860 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_003830046   ⟸   XM_003829998
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_003830045   ⟸   XM_003829997
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003830047   ⟸   XM_003829999
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008953610   ⟸   XM_008955362
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034814872   ⟸   XM_034958981
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034814871   ⟸   XM_034958980
- Peptide Label: isoform X5
RefSeq Acc Id: ENSPPAP00000040545   ⟸   ENSPPAT00000063462
RefSeq Acc Id: ENSPPAP00000040551   ⟸   ENSPPAT00000063468
RefSeq Acc Id: ENSPPAP00000040552   ⟸   ENSPPAT00000063469
RefSeq Acc Id: ENSPPAP00000040547   ⟸   ENSPPAT00000063464
RefSeq Acc Id: ENSPPAP00000040542   ⟸   ENSPPAT00000063459
RefSeq Acc Id: ENSPPAP00000040555   ⟸   ENSPPAT00000063472
Protein Domains
CTNNB1_binding   HMG box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042910 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000040542 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000040545 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000040547 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000040551 UniProtKB/TrEMBL
  ENSPPAP00000040552 UniProtKB/TrEMBL
  ENSPPAP00000040555 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063459 UniProtKB/TrEMBL
  ENSPPAT00000063462 UniProtKB/TrEMBL
  ENSPPAT00000063464 UniProtKB/TrEMBL
  ENSPPAT00000063468 UniProtKB/TrEMBL
  ENSPPAT00000063469 UniProtKB/TrEMBL
  ENSPPAT00000063472 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/TrEMBL
InterPro Catenin_binding_dom_sf UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  LEF1 UniProtKB/TrEMBL
  TCF/LEF UniProtKB/TrEMBL
KEGG Report pps:100995847 UniProtKB/TrEMBL
NCBI Gene LEF1 ENTREZGENE
PANTHER PTHR10373 UniProtKB/TrEMBL
  PTHR10373:SF11 UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A2R9CF05_PANPA UniProtKB/TrEMBL
  A0A2R9CF20_PANPA UniProtKB/TrEMBL
  A0A2R9CF31_PANPA UniProtKB/TrEMBL
  A0A2R9CPR7_PANPA UniProtKB/TrEMBL
  A0A2R9CPR9_PANPA UniProtKB/TrEMBL
  A0A2R9CPS3_PANPA UniProtKB/TrEMBL