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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol
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Accession:CHEBI:91704 term browser browse the term
Definition:An aromatic ether that has formula C15H23NO3.
Synonyms:related_synonym: (+/-)-Oxprenolol;   Formula=C15H23NO3;   InChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3;   InChIKey=CEMAWMOMDPGJMB-UHFFFAOYSA-N;   SMILES=CC(C)NCC(COC1=CC=CC=C1OCC=C)O;   dl-Oxprenolol;   oxprenolol HCl;   oxprenolol hydrochloride
 xref: CAS:6452-71-7;   Drug_Central:2027;   HMDB:HMDB0015520;   LINCS:LSM-1554
 xref_mesh: MESH:D010096


show annotations for term's descendants           Sort by:
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenergic receptor, beta 1 multiple interactions ISO Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Adrb3 adrenergic receptor, beta 3 multiple interactions ISO Oxprenolol binds to and results in increased activity of ADRB3 protein CTD PMID:1682311 NCBI chr 8:27,715,804...27,720,833
Ensembl chr 8:27,715,804...27,740,644 		JBrowse link
G Avp arginine vasopressin decreases expression ISO Oxprenolol results in decreased expression of AVP protein CTD PMID:6367368 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Ren1 renin 1 structural multiple interactions
decreases activity		 ISO [Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein
Oxprenolol results in decreased activity of REN protein		 CTD PMID:6173514 PMID:6344036 PMID:7023672 PMID:7049707 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    chemical entity 22193
      group 22089
        polyatomic entity 22089
          molecule 21688
            organic molecule 21664
              organic cyclic compound 21273
                organic aromatic compound 20757
                  aromatic ether 16762
                    1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    main group molecular entity 22120
                      p-block molecular entity 22120
                        carbon group molecular entity 21921
                          organic molecular entity 21847
                            heteroorganic entity 21503
                              organochalcogen compound 20992
                                organooxygen compound 20834
                                  ether 18193
                                    aromatic ether 16762
                                      1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol 7
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