CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: alborixin
Accession: CHEBI:77940
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Definition: A polyether antibiotic that is isolated from cultures of a strain of Streptomyces albus.
Synonyms: exact_synonym: (2R)-2-[(2S,3S,5R,6S)-6-{(2R,3S)-3-[(2R,5S,6R)-6-({(2R,3S,5R,6R)-6-[(R)-{(2S,2'R,3'R,5S,5'S)-5'-[(2R,5R,6S)-6-ethyl-5-hydroxy-5-methyltetrahydro-2H-pyran-2-yl]-2'-hydroxy-2,3',5'-trimethyloctahydro-2,2'-bifuran-5-yl}(hydroxy)methyl]-6-hydroxy-3,5-dimethyltetrahydro-2H-pyran-2-yl}methyl)-6-hydroxy-5-methyltetrahydro-2H-pyran-2-yl]-2-hydroxybutyl}-3,5-dimethyltetrahydro-2H-pyran-2-yl]propanoic acid
related_synonym: Antibiotic S 14750A; Formula=C48H84O14; InChI=1S/C48H84O14/c1-13-38-43(10,53)18-17-39(58-38)44(11)23-30(7)48(56,62-44)45(12)19-16-35(59-45)41(50)47(55)29(6)21-26(3)37(61-47)24-46(54)28(5)14-15-34(60-46)31(8)33(49)22-36-25(2)20-27(4)40(57-36)32(9)42(51)52/h25-41,49-50,53-56H,13-24H2,1-12H3,(H,51,52)/t25-,26+,27+,28+,29-,30-,31+,32-,33-,34-,35+,36+,37-,38+,39-,40+,41-,43-,44+,45+,46-,47-,48-/m1/s1; InChIKey=WWDHGOLBPBWCNJ-GXXSWWTOSA-N; SMILES=CC[C@@H]1O[C@H](CC[C@@]1(C)O)[C@]1(C)C[C@@H](C)[C@@](O)(O1)[C@]1(C)CC[C@H](O1)[C@@H](O)[C@]1(O)O[C@H](C[C@@]2(O)O[C@H](CC[C@@H]2C)[C@@H](C)[C@H](O)C[C@@H]2O[C@H]([C@@H](C)C(O)=O)[C@@H](C)C[C@H]2C)[C@@H](C)C[C@H]1C
xref: CAS:57760-36-8
xref_mesh: MESH:C012708
xref: PMID:1929322; PMID:28761; PMID:3572663; PMID:3823605; PMID:511789; PMID:541267; PMID:7193017; PMID:7785984; PMID:94632; PMID:950314; PMID:956055; Patent:US4933364; Reaxys:6262683
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BAX
BCL2 associated X, apoptosis regulator
increases expression
EXP
alborixin results in increased expression of BAX protein
CTD
PMID:27378626
NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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BCL2
BCL2 apoptosis regulator
decreases expression
EXP
alborixin results in decreased expression of BCL2 protein
CTD
PMID:27378626
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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CASP3
caspase 3
increases cleavage
EXP
alborixin results in increased cleavage of CASP3 protein
CTD
PMID:27378626
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CASP8
caspase 8
increases activity
EXP
alborixin results in increased activity of CASP8 protein
CTD
PMID:27378626
NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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CASP9
caspase 9
increases activity
EXP
alborixin results in increased activity of CASP9 protein
CTD
PMID:27378626
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
G
PARP1
poly(ADP-ribose) polymerase 1
increases cleavage
EXP
alborixin results in increased cleavage of PARP1 protein
CTD
PMID:27378626
NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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