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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:masitinib
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Accession:CHEBI:63450 term browser browse the term
Definition:A member of the class of benzamides that is the carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine. It is a highly selective oral tyrosine kinase inhibitor.
Synonyms:exact_synonym: 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide
 related_synonym: AB 1010;   AB1010;   Formula=C28H30N6OS;   InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32);   InChIKey=WJEOLQLKVOPQFV-UHFFFAOYSA-N;   SMILES=CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nc(cs2)-c2cccnc2)c1
 xref: CAS:790299-79-5;   Drug_Central:4791;   LINCS:LSM-1130
 xref_mesh: MESH:C526575
 xref: PMID:19549290;   PMID:19789626;   PMID:20033487;   PMID:20211560;   PMID:21034327;   PMID:21333567;   PMID:21504563;   PMID:21668810;   Reaxys:12083382


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masitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO masitinib results in decreased activity of FGFR3 protein CTD PMID:19789626 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO masitinib results in decreased phosphorylation of and results in decreased activity of KIT protein
masitinib binds to and results in decreased phosphorylation of and results in decreased activity of KIT protein
CTD PMID:19789626 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity ISO masitinib results in decreased activity of LYN protein CTD PMID:19789626 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases activity ISO masitinib results in decreased activity of PDGFRA protein CTD PMID:19789626 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases activity ISO masitinib results in decreased activity of PDGFRB protein CTD PMID:19789626 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO masitinib results in decreased secretion of TNF protein CTD PMID:19789626 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              masitinib 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                monocarboxylic acid amide 15008
                                                  arenecarboxamide 7262
                                                    benzamides 7262
                                                      masitinib 6
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