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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:masitinib
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Accession:CHEBI:63450 term browser browse the term
Definition:A member of the class of benzamides that is the carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine. It is a highly selective oral tyrosine kinase inhibitor.
Synonyms:exact_synonym: 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide
 related_synonym: AB 1010;   AB1010;   Formula=C28H30N6OS;   InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32);   InChIKey=WJEOLQLKVOPQFV-UHFFFAOYSA-N;   SMILES=CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nc(cs2)-c2cccnc2)c1
 xref: CAS:790299-79-5;   Drug_Central:4791;   LINCS:LSM-1130
 xref_mesh: MESH:C526575
 xref: PMID:19549290;   PMID:19789626;   PMID:20033487;   PMID:20211560;   PMID:21034327;   PMID:21333567;   PMID:21504563;   PMID:21668810;   Reaxys:12083382


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masitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of masitinib CTD PMID:36048877
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of masitinib CTD PMID:36048877 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO masitinib results in decreased activity of FGFR3 protein CTD PMID:19789626 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO masitinib results in decreased phosphorylation of and results in decreased activity of KIT protein
masitinib binds to and results in decreased phosphorylation of and results in decreased activity of KIT protein		 CTD PMID:19789626 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity ISO masitinib results in decreased activity of LYN protein CTD PMID:19789626 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases activity ISO masitinib results in decreased activity of PDGFRA protein CTD PMID:19789626 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases activity ISO masitinib results in decreased activity of PDGFRB protein CTD PMID:19789626 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion
multiple interactions		 ISO masitinib results in increased secretion of TGFB1 protein
[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with masitinib] results in increased secretion of TGFB1 protein; [masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein		 CTD PMID:35007524 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO masitinib results in decreased secretion of TNF protein CTD PMID:19789626 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
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  CHEBI ontology 19915
    role 19885
      application 19727
        pharmaceutical 19541
          drug 19560
            antineoplastic agent 17817
              masitinib 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19542
                              organochalcogen compound 19302
                                organooxygen compound 19218
                                  carbon oxoacid 18664
                                    carboxylic acid 18661
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17551
                                            carboxamide 17581
                                              monocarboxylic acid amide 15751
                                                arenecarboxamide 8259
                                                  benzamides 8254
                                                    masitinib 9
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