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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:marimastat
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Accession:CHEBI:50662 term browser browse the term
Definition:A secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide.
Synonyms:exact_synonym: (2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide
 related_synonym: Formula=C15H29N3O5;   InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1;   InChIKey=OCSMOTCMPXTDND-OUAUKWLOSA-N;   SMILES=CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
 xref: DrugBank:DB00786;   KEGG:D03795
 xref_mesh: MESH:C100342



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marimastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin multiple interactions ISO marimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of AREG protein] CTD PMID:15342401 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO marimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of AREG protein]; marimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of TGFA protein] CTD PMID:15342401 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP marimastat inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein] CTD PMID:15574683 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP marimastat inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein] CTD PMID:15574683 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP marimastat inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK8 protein] CTD PMID:15574683 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO marimastat inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein] CTD PMID:22340517 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO marimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of TGFA protein] CTD PMID:15342401 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19715
    role 19690
      application 19522
        pharmaceutical 19409
          drug 19409
            antineoplastic agent 17597
              marimastat 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19715
    subatomic particle 19713
      composite particle 19713
        hadron 19713
          baryon 19713
            nucleon 19713
              atomic nucleus 19713
                atom 19713
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19606
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18792
                              organic divalent group 18777
                                organodiyl group 18777
                                  carbonyl group 18743
                                    carbonyl compound 18743
                                      carboxylic acid 18443
                                        carboacyl group 17599
                                          univalent carboacyl group 17599
                                            carbamoyl group 17435
                                              carboxamide 17435
                                                secondary carboxamide 582
                                                  marimastat 7
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