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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:secondary carboxamide
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Accession:CHEBI:140325 term browser browse the term
Definition:A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
Synonyms:related_synonym: Formula=CHNOR2;   SMILES=N(C(*)=O)(*)[H];   secondary carboxamides



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abexinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated decreases expression ISO abexinostat results in decreased expression of BRCA2 mRNA CTD PMID:18042714 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Bortezomib co-treated with abexinostat] results in increased activity of CASP3 protein CTD PMID:19417023 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO Bortezomib promotes the reaction [abexinostat results in increased cleavage of CASP8 protein] CTD PMID:19417023 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO Bortezomib promotes the reaction [abexinostat results in increased cleavage of CASP9 protein] CTD PMID:19417023 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO abexinostat results in decreased expression of CCL3 mRNA CTD PMID:19417023 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO abexinostat results in decreased expression of CCL7 mRNA CTD PMID:19417023 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Bortezomib promotes the reaction [abexinostat results in increased expression of CDKN1A protein] CTD PMID:19417023 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO abexinostat results in increased expression of GADD45G mRNA CTD PMID:18042714 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO abexinostat promotes the reaction [Bortezomib results in increased expression of HMOX1 mRNA]
abexinostat results in increased expression of HMOX1 mRNA
CTD PMID:19417023 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 decreases expression
multiple interactions
ISO abexinostat results in decreased expression of HMOX2 mRNA
abexinostat promotes the reaction [Bortezomib results in decreased expression of HMOX2 mRNA]
CTD PMID:19417023 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases expression
ISO Bortezomib promotes the reaction [abexinostat results in decreased expression of IKBKB mRNA] CTD PMID:19417023 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO [Bortezomib co-treated with abexinostat] results in decreased expression of MYC mRNA; Bortezomib promotes the reaction [abexinostat results in decreased expression of MYC protein] CTD PMID:19417023 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO abexinostat results in decreased expression of NFKB1 mRNA CTD PMID:19417023 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [Bortezomib co-treated with abexinostat] results in increased activity of PARP1 protein; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [abexinostat results in increased cleavage of PARP1 protein] CTD PMID:18042714 PMID:19417023 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO abexinostat results in decreased expression of RAD51 mRNA; abexinostat results in decreased expression of RAD51 protein CTD PMID:18042714 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit decreases expression ISO abexinostat results in decreased expression of RELB mRNA CTD PMID:19417023 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
JBrowse link
G Txn2 thioredoxin 2 decreases expression
multiple interactions
ISO abexinostat results in decreased expression of TXN2 mRNA
abexinostat promotes the reaction [Bortezomib results in decreased expression of TXN2 mRNA]
CTD PMID:19417023 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression
multiple interactions
ISO abexinostat results in decreased expression of TXNRD2 mRNA
abexinostat promotes the reaction [Bortezomib results in decreased expression of TXNRD2 mRNA]
CTD PMID:19417023 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
acalabrutinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein affects expression ISO acalabrutinib affects the expression of CRP protein CTD PMID:32503877 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
affects metabolic processing
ISO CYP3A4 protein results in increased metabolism of acalabrutinib
Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib]
CTD PMID:34153224 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Il6 interleukin 6 decreases expression ISO acalabrutinib results in decreased expression of IL6 protein CTD PMID:32503877 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects binding ISO acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases abundance
affects abundance
ISO ACLY protein results in increased abundance of Acetyl Coenzyme A
ACLY protein affects the abundance of Acetyl Coenzyme A
CTD PMID:28077572 PMID:36933457 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G App amyloid beta precursor protein affects localization
increases secretion
multiple interactions
ISO APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]
CTD PMID:16122837 PMID:22906069 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Crat carnitine O-acetyltransferase decreases activity EXP Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein CTD PMID:8075222 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor decreases abundance
multiple interactions
ISO ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]
CTD PMID:25440059 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Fluoxetine results in decreased expression of G6PC1 protein] which results in increased abundance of Acetyl Coenzyme A CTD PMID:33179799 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] CTD PMID:16122837 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kat2b lysine acetyltransferase 2B affects binding ISO Acetyl Coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
JBrowse link
G Metrnl meteorin-like, glial cell differentiation regulator multiple interactions ISO METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] CTD PMID:30213948 NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
affects binding
ISO [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein
CTD PMID:20545351 PMID:22835378 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
acryloyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Echs1 enoyl-CoA hydratase, short chain 1 increases abundance ISO ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A CTD PMID:25125611 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase increases abundance ISO HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A CTD PMID:25125611 NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824
JBrowse link
afatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AKT1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein] CTD PMID:36460225 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [CALM2 protein affects the susceptibility to Afatinib] which affects the expression of BAX protein; BAX protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein] CTD PMID:36460225 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO BBC3 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein] CTD PMID:36460225 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Calm2 calmodulin 2 multiple interactions
affects response to substance
ISO [CALM2 protein affects the susceptibility to Afatinib] which affects the expression of BAX protein; [CALM2 protein affects the susceptibility to Afatinib] which affects the localization of DIABLO protein; [CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein; AKT1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; BAX protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; BBC3 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; MCL1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein] CTD PMID:36460225 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein; AKT1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; BAX protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; BBC3 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; MCL1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein] CTD PMID:36460225 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO [CALM2 protein affects the susceptibility to Afatinib] which affects the localization of DIABLO protein CTD PMID:36460225 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Egf epidermal growth factor multiple interactions ISO afatinib inhibits the reaction [EGF protein results in increased expression of EHMT2 protein]; afatinib inhibits the reaction [EGF protein results in increased expression of POU5F1 protein] CTD PMID:28787001 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor decreases activity
decreases phosphorylation
ISO afatinib results in decreased activity of EGFR protein; afatinib results in decreased activity of EGFR protein mutant form
afatinib results in decreased phosphorylation of EGFR protein
CTD PMID:21322567 PMID:22242139 PMID:28787001 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 multiple interactions ISO afatinib inhibits the reaction [EGF protein results in increased expression of EHMT2 protein] CTD PMID:28787001 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO afatinib results in decreased expression of IKBKB protein CTD PMID:22242139 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 decreases phosphorylation ISO Afatinib results in decreased phosphorylation of IQGAP1 protein CTD PMID:33087447 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO MCL1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein] CTD PMID:36460225 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Afatinib inhibits the reaction [[Smoke results in increased abundance of Particulate Matter] which results in increased expression of MUC5AC mRNA] CTD PMID:31944254 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO afatinib results in decreased activity of [RELA protein binds to NFKB1 protein] CTD PMID:22242139 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions
ISO afatinib results in decreased expression of POU5F1 protein
afatinib inhibits the reaction [EGF protein results in increased expression of POU5F1 protein]
CTD PMID:28787001 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO afatinib results in decreased activity of [RELA protein binds to NFKB1 protein] CTD PMID:22242139 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Set Set nuclear proto-oncogene affects localization ISO Afatinib affects the localization of SET protein alternative form CTD PMID:36534342 NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567
JBrowse link
amperozide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO amperozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
arachidonoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
arachidonyl-2'-chloroethylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide decreases expression EXP arachidonyl-2-chloroethylamide results in decreased expression of AGRP mRNA CTD PMID:26468265 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO arachidonyl-2-chloroethylamide results in decreased phosphorylation of AKT1 protein CTD PMID:26847930 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Angpt1 angiopoietin 1 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of ANGPT1 protein] CTD PMID:26467187 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Angpt2 angiopoietin 2 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of ANGPT2 protein] CTD PMID:26467187 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G Avp arginine vasopressin multiple interactions EXP arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA] CTD PMID:26468265 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO [Streptozocin co-treated with arachidonyl-2-chloroethylamide] results in increased expression of BCL2 protein
arachidonyl-2-chloroethylamide results in increased expression of BCL2 protein
CTD PMID:30607903 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cartpt CART prepropeptide decreases expression
multiple interactions
EXP arachidonyl-2-chloroethylamide results in decreased expression of CARTPT mRNA
[arachidonyl-2-chloroethylamide co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CARTPT mRNA
CTD PMID:26468265 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp3 caspase 3 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:31256211 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:31256211 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression
multiple interactions
ISO arachidonyl-2-chloroethylamide results in increased expression of CCL4 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CCL4 mRNA]; AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CCL4 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of CCL4 mRNA]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CCL4 mRNA]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CCL4 mRNA]
CTD PMID:29033935 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions
ISO arachidonyl-2-chloroethylamide results in increased expression of CD86 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CD86 mRNA]; AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CD86 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of CD86 mRNA]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CD86 mRNA]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of CD86 mRNA]
CTD PMID:29033935 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP
ISO
CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of CCL4 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of CD86 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of ESRRG mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of IL6 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF protein]
CTD PMID:12734338 PMID:27455076 PMID:29033935 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Dagla diacylglycerol lipase, alpha multiple interactions
increases expression
ISO ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]
arachidonyl-2-chloroethylamide promotes the reaction [ESRRG protein binds to DAGLA promoter]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA protein]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]
arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA; arachidonyl-2-chloroethylamide results in increased expression of DAGLA protein
CTD PMID:31912162 NCBI chr 1:206,890,635...206,947,332
Ensembl chr 1:206,890,638...206,947,232
JBrowse link
G Daglb diacylglycerol lipase, beta increases expression
multiple interactions
ISO arachidonyl-2-chloroethylamide results in increased expression of DAGLB mRNA
ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLB mRNA]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLB mRNA]
arachidonyl-2-chloroethylamide promotes the reaction [ESRRG protein binds to DAGLB promoter]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLB mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLB]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLB mRNA]
CTD PMID:31912162 NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [Cisplatin results in increased expression of DDIT3 protein] CTD PMID:31256211 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP arachidonyl-2-chloroethylamide results in decreased expression of DRD2 mRNA CTD PMID:22791651 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Esrrg estrogen-related receptor gamma increases expression
multiple interactions
ISO
EXP
arachidonyl-2-chloroethylamide results in increased expression of ESRRG mRNA; arachidonyl-2-chloroethylamide results in increased expression of ESRRG protein
ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLB mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA]
arachidonyl-2-chloroethylamide promotes the reaction [ESRRG protein binds to DAGLA promoter]; arachidonyl-2-chloroethylamide promotes the reaction [ESRRG protein binds to DAGLB promoter]; arachidonyl-2-chloroethylamide promotes the reaction [ESRRG protein binds to FGF21 promoter]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of ESRRG mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA protein]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLB mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of DAGLB]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased secretion of FGF21 protein]
CTD PMID:27455076 PMID:30019168 PMID:31912162 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
JBrowse link
G Fga fibrinogen alpha chain increases expression
multiple interactions
ISO arachidonyl-2-chloroethylamide results in increased expression of FGA mRNA
GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGA mRNA]
CTD PMID:30019168 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain multiple interactions
increases expression
ISO GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGB mRNA] CTD PMID:30019168 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
increases secretion
multiple interactions
ISO
EXP
arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA
arachidonyl-2-chloroethylamide results in increased secretion of FGF21 protein
arachidonyl-2-chloroethylamide promotes the reaction [ESRRG protein binds to FGF21 promoter]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA]; ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased secretion of FGF21 protein]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased secretion of FGF21 protein]
ESRRG protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA]; GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA]
arachidonyl-2-chloroethylamide results in increased expression of FGF21 mRNA; arachidonyl-2-chloroethylamide results in increased expression of FGF21 protein
CTD PMID:27455076 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Fgg fibrinogen gamma chain increases expression
multiple interactions
ISO arachidonyl-2-chloroethylamide results in increased expression of FGG mRNA
GSK5182 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of FGG mRNA]
CTD PMID:30019168 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
decreases phosphorylation
ISO FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]]]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide results in decreased expression of NFE2L2 mRNA]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide results in decreased expression of NRF1 mRNA]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide results in decreased expression of PPARGC1A mRNA]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide results in decreased expression of TFAM mRNA]
arachidonyl-2-chloroethylamide results in decreased phosphorylation of FOXO1 protein
CTD PMID:26847930 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]]] CTD PMID:26847930 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein results in increased activity of GSR protein] CTD PMID:26671069 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hcrt hypocretin neuropeptide precursor increases expression EXP arachidonyl-2-chloroethylamide results in increased expression of HCRT mRNA CTD PMID:26468265 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO arachidonyl-2-chloroethylamide results in increased expression of IL6 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of IL6 mRNA]; AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of IL6 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of IL6 mRNA]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of IL6 mRNA]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of IL6 mRNA]
CTD PMID:29033935 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions ISO [arachidonyl-2-chloroethylamide co-treated with Glucose] results in increased secretion of INS1 protein; arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]]; arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]; arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein results in increased activity of GSR protein]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of G6PC1 protein]]]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]] CTD PMID:26671069 PMID:26847930 PMID:30761839 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of MAPK1 protein]; arachidonyl-2-chloroethylamide promotes the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of MAPK1 protein]
arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK1 protein
arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:12734338 PMID:19477951 PMID:26467187 PMID:29033935 PMID:30607903 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of MAPK3 protein]; arachidonyl-2-chloroethylamide promotes the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of MAPK3 protein]
arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:12734338 PMID:19477951 PMID:26467187 PMID:29033935 PMID:30607903 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [arachidonyl-2-chloroethylamide results in increased activity of MPO protein]; AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased activity of MPO protein]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased activity of MPO protein]; SB 203580 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased activity of MPO protein] CTD PMID:32033504 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
ISO FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide results in decreased expression of NFE2L2 mRNA] CTD PMID:26847930 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 protein]; AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 mRNA]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 mRNA]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 protein]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 mRNA]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of NOS2 protein] CTD PMID:29033935 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
decreases expression
ISO FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide results in decreased expression of NRF1 mRNA] CTD PMID:26847930 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions EXP arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased secretion of OXT protein] CTD PMID:26468265 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:31256211 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]; FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [INS1 protein inhibits the reaction [[Cyclic AMP co-treated with Dexamethasone] results in increased expression of PEPCK protein]]] CTD PMID:26847930 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pmch pro-melanin-concentrating hormone multiple interactions
increases expression
EXP arachidonyl-2-chloroethylamide promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of PMCH mRNA]
arachidonyl-2-chloroethylamide results in increased expression of PMCH mRNA
CTD PMID:26468265 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
JBrowse link
G Pomc proopiomelanocortin multiple interactions
decreases expression
EXP arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA]
arachidonyl-2-chloroethylamide results in decreased expression of POMC mRNA
CTD PMID:26468265 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression
ISO FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide results in decreased expression of PPARGC1A mRNA] CTD PMID:26847930 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide affects the localization of RELA protein]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide affects the localization of RELA protein]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide affects the localization of RELA protein] CTD PMID:29033935 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases activity
ISO AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased activity of RHOA protein]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased activity of RHOA protein] CTD PMID:29033935 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression
multiple interactions
ISO arachidonyl-2-chloroethylamide results in decreased expression of TFAM mRNA
FOXO1 protein affects the reaction [arachidonyl-2-chloroethylamide results in decreased expression of TFAM mRNA]
CTD PMID:26847930 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO arachidonyl-2-chloroethylamide results in increased expression of TNF mRNA; arachidonyl-2-chloroethylamide results in increased expression of TNF protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF protein]; AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF mRNA]; AM 281 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF protein]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF mRNA]; CNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF protein]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF mRNA]; Pertussis Toxin inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF protein]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF mRNA]; Y 27632 inhibits the reaction [arachidonyl-2-chloroethylamide results in increased expression of TNF protein]
CTD PMID:29033935 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO arachidonyl-2-chloroethylamide inhibits the reaction [Cisplatin results in increased phosphorylation of TRP53 protein] CTD PMID:31256211 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO AM 251 inhibits the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFA protein]]; arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFA protein] CTD PMID:26467187 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO AM 251 inhibits the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFC protein]]; arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFC protein] CTD PMID:26467187 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
JBrowse link
asperphenamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L multiple interactions ISO asperphenamate analog binds to and results in decreased activity of CTSL protein CTD PMID:30253340 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Ctss cathepsin S multiple interactions ISO asperphenamate analog binds to and results in decreased activity of CTSS protein CTD PMID:30253340 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
batimastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO batimastat results in decreased metabolism of and results in decreased secretion of ACHE protein CTD PMID:23047022 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Areg amphiregulin decreases secretion
multiple interactions
ISO batimastat results in decreased secretion of AREG protein
batimastat inhibits the reaction [pervanadate results in increased cleavage of AREG protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of AREG protein]
CTD PMID:9685416 PMID:27117977 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO batimastat inhibits the reaction [pervanadate results in increased cleavage of ERBB4 protein] CTD PMID:9685416 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Ereg epiregulin multiple interactions ISO batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of EREG protein] CTD PMID:27117977 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases activity ISO batimastat results in decreased activity of FURIN protein CTD PMID:15632106 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha decreases cleavage ISO batimastat results in decreased cleavage of IL5RA protein CTD PMID:12444155 NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases activity
multiple interactions
ISO batimastat results in decreased activity of MAPK1 protein
batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein]
CTD PMID:15247267 PMID:15319441 PMID:27117977 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity
multiple interactions
ISO batimastat results in decreased activity of MAPK3 protein
batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]
CTD PMID:15247267 PMID:15319441 PMID:27117977 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nts neurotensin multiple interactions ISO batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; batimastat inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15247267 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; batimastat inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; batimastat inhibits the reaction [TAC1 protein results in increased secretion of TGFA protein] CTD PMID:15319441 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
decreases secretion
ISO batimastat inhibits the reaction [TAC1 protein results in increased secretion of TGFA protein]; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TGFA protein]
batimastat results in decreased secretion of TGFA protein
CTD PMID:15319441 PMID:27117977 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases activity ISO batimastat results in decreased activity of TIMP2 protein CTD PMID:15632106 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO batimastat inhibits the reaction [tributyltin results in increased secretion of TNF protein] CTD PMID:29532501 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
bictegravir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO bictegravir results in decreased expression of ALDH1A2 mRNA CTD PMID:34515794 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO bictegravir results in increased expression of CYP26A1 mRNA CTD PMID:34515794 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO bictegravir results in increased expression of FGF8 mRNA CTD PMID:34515794 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Mixl1 Mix paired-like homeobox 1 increases expression ISO bictegravir results in increased expression of MIXL1 mRNA CTD PMID:34515794 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065
JBrowse link
butyryl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kat2b lysine acetyltransferase 2B affects binding ISO butyryl-coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
JBrowse link
capivasertib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO capivasertib results in increased phosphorylation of AKT1 protein CTD PMID:26853465 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation ISO capivasertib results in decreased phosphorylation of AKT1S1 protein CTD PMID:26853465 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO capivasertib affects the reaction [bafilomycin A1 results in increased expression of BNIP3 protein] CTD PMID:26853465 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein; CA 074 methyl ester inhibits the reaction [[capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein] CTD PMID:26853465 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO bafilomycin A1 promotes the reaction [capivasertib results in increased expression of MAP1LC3B protein modified form] CTD PMID:26853465 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Rpl18 ribosomal protein L18 multiple interactions ISO capivasertib inhibits the reaction [sodium arsenite results in increased expression of RPL18 mRNA]; capivasertib inhibits the reaction [sodium arsenite results in increased expression of RPL18 protein] CTD PMID:37061066 NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452
JBrowse link
G Rps21-ps1 ribosomal protein S21, pseudogene 1 multiple interactions ISO capivasertib inhibits the reaction [sodium arsenite results in increased expression of RPS21 mRNA]; capivasertib inhibits the reaction [sodium arsenite results in increased expression of RPS21 protein] CTD PMID:37061066 NCBI chr 5:153,387,133...153,387,476
Ensembl chr 5:153,387,176...153,387,427
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO capivasertib results in decreased phosphorylation of RPS6 protein CTD PMID:26853465 PMID:32397857 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Sqstm1 sequestosome 1 affects expression ISO capivasertib affects the expression of SQSTM1 protein CTD PMID:26853465 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO capivasertib results in decreased expression of SREBF1 protein CTD PMID:26853465 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 multiple interactions ISO capivasertib inhibits the reaction [sodium arsenite results in increased expression of UBA52 mRNA]; capivasertib inhibits the reaction [sodium arsenite results in increased expression of UBA52 protein] CTD PMID:37061066 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
JBrowse link
carboxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 decreases expression ISO Carboxin results in decreased expression of ANXA2 mRNA CTD PMID:33512557 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Bbc3 Bcl-2 binding component 3 decreases expression ISO Carboxin results in decreased expression of BBC3 mRNA CTD PMID:33512557 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
CDN1163 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mttp microsomal triglyceride transfer protein multiple interactions ISO CDN1163 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MTTP protein] CTD PMID:34516972 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
coenzyme A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot8 acyl-CoA thioesterase 8 affects hydrolysis ISO ACOT8 protein affects the hydrolysis of Coenzyme A analog CTD PMID:16141203 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851
JBrowse link
G Kat2b lysine acetyltransferase 2B affects binding ISO Coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
JBrowse link
copanlisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO copanlisib results in decreased phosphorylation of AKT1 protein CTD PMID:31445927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO copanlisib affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO copanlisib results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
CX-5461 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated affects response to substance
multiple interactions
ISO BRCA2 protein affects the susceptibility to CX 5461
BRCA2 protein affects the reaction [CX 5461 results in increased expression of TP53BP1 protein]; BRCA2 protein affects the reaction [CX 5461 results in increased phosphorylation of RPA2 protein]
CTD PMID:28211448 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO CX 5461 results in increased phosphorylation of CHEK1 protein CTD PMID:28211448 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO CX 5461 results in increased phosphorylation of CHEK2 protein CTD PMID:28211448 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G H2ax H2A.X variant histone increases expression ISO CX 5461 results in increased expression of H2AX protein CTD PMID:28211448 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO CX 5461 results in increased cleavage of PARP1 protein CTD PMID:32799625 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO CX 5461 results in increased expression of RAD51 protein CTD PMID:28211448 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation
multiple interactions
ISO CX 5461 results in increased phosphorylation of RPA2 protein
BRCA2 protein affects the reaction [CX 5461 results in increased phosphorylation of RPA2 protein]
CTD PMID:28211448 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions
increases expression
ISO BRCA2 protein affects the reaction [CX 5461 results in increased expression of TP53BP1 protein] CTD PMID:28211448 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
dacomitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
affects metabolic processing
ISO Quinidine affects the reaction [CYP2D6 protein polymorphism affects the metabolism of dacomitinib] CTD PMID:34936353 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO dacomitinib inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein] CTD PMID:27491023 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
DDR1-IN-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions
decreases phosphorylation
ISO DDR1-IN-1 inhibits the reaction [collagen increases DDR1 autophosphorylation in human cell lines]
DDR1-IN-1 decreases DDR1 phosphorylation in human cancer cells in mouse model
DDR1-IN-1 inhibits the reaction [collagen increases phosphorylation of DDR1 in human melanoma cells]
RGD PMID:23899692 PMID:26719540 PMID:31271515 RGD:152995467, RGD:11520844, RGD:151347864 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
JBrowse link
DDR1-IN-2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions ISO DDR1-IN-2 inhibits the reaction [collagen increases DDR1 autophosphorylation in human cell lines] RGD PMID:23899692 RGD:152995467 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
JBrowse link
decanoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsdl2 hydroxysteroid dehydrogenase like 2 multiple interactions ISO [decanoyl-coenzyme A co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [decanoyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
dolutegravir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO dolutegravir results in decreased expression of ALDH1A2 mRNA CTD PMID:34515794 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Cdx1 caudal type homeo box 1 decreases expression ISO dolutegravir results in decreased expression of CDX1 mRNA CTD PMID:34515794 NCBI chr18:54,472,587...54,490,913
Ensembl chr18:54,473,444...54,490,814
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression
increases expression
ISO dolutegravir results in decreased expression of CYP26A1 mRNA
dolutegravir results in increased expression of CYP26A1 mRNA
CTD PMID:34515794 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO dolutegravir results in increased expression of FGF8 mRNA CTD PMID:34515794 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Hoxb1 homeo box B1 increases expression ISO dolutegravir results in increased expression of HOXB1 mRNA CTD PMID:34515794 NCBI chr10:81,331,507...81,332,928
Ensembl chr10:81,331,507...81,332,836
JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO dolutegravir results in decreased expression of HOXB9 mRNA CTD PMID:34515794 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO dolutegravir results in decreased expression of MEOX1 mRNA CTD PMID:34515794 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 increases expression ISO dolutegravir results in increased expression of MESP2 mRNA CTD PMID:34515794 NCBI chr 1:133,756,601...133,759,207
Ensembl chr 1:133,756,601...133,759,198
JBrowse link
G Mixl1 Mix paired-like homeobox 1 increases expression ISO dolutegravir results in increased expression of MIXL1 mRNA CTD PMID:34515794 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065
JBrowse link
G Tbx6 T-box transcription factor 6 increases expression ISO dolutegravir results in increased expression of TBX6 mRNA CTD PMID:34515794 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593
JBrowse link
dysidenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO dysidenin inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; dysidenin inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; dysidenin inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m] CTD PMID:12488351 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
glutaryl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot4 acyl-CoA thioesterase 4 affects hydrolysis ISO ACOT4 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acot8 acyl-CoA thioesterase 8 affects hydrolysis ISO ACOT8 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851
JBrowse link
glycolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
ISO [CYP3A4 protein results in increased hydroxylation of glycolithocholic acid] which results in increased abundance of glycohyodeoxycholic acid CTD PMID:36473578 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases abundance ISO HSD11B1 gene mutant form results in decreased abundance of glycolithocholic acid CTD PMID:25061560 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of glycolithocholic acid CTD PMID:25034404 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of glycolithocholic acid CTD PMID:36473578 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
JBrowse link
glycoursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of glycoursodeoxycholic acid CTD PMID:36473578 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Edn1 endothelin 1 decreases expression ISO glycoursodeoxycholic acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO [glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form CTD PMID:18188457 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
glycyl-L-phenylalanine 2-naphthylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nox1 NADPH oxidase 1 multiple interactions ISO 1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]; NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] CTD PMID:24912985 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
GSK343 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III increases expression ISO GSK343 results in increased expression of DICER1 mRNA CTD PMID:25351418 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases activity ISO GSK343 results in decreased activity of EZH2 protein CTD PMID:23759589 PMID:24900432 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
hexanoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [hexanoyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
isobutyryl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kat2b lysine acetyltransferase 2B affects binding ISO isobutyryl-coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
JBrowse link
lauroyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO lauroyl-coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 multiple interactions ISO [lauroyl-coenzyme A co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [lauroyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
LGK974 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased expression of BAK1 protein] CTD PMID:30205152 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Casp3 caspase 3 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein] CTD PMID:30205152 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in decreased expression of CCND1 protein] CTD PMID:30205152 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat affects the localization of CTNNB1 protein]; LGK974 inhibits the reaction [Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein] CTD PMID:30205152 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased transport of DIABLO protein] CTD PMID:30205152 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased transport of HTRA2 protein] CTD PMID:30205152 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:30205152 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
LLY-507 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA CTD PMID:29718165 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Ifng interferon gamma multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA CTD PMID:29718165 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA CTD PMID:29718165 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Marco macrophage receptor with collagenous structure multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA CTD PMID:29718165 NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA CTD PMID:29718165 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA CTD PMID:29718165 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Smyd2 SET and MYND domain containing 2 multiple interactions ISO LLY-507 binds to and results in decreased activity of SMYD2 protein CTD PMID:25825497 NCBI chr13:101,425,270...101,466,576
Ensembl chr13:101,425,273...101,466,576
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA CTD PMID:29718165 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
malonyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlycd malonyl-CoA decarboxylase multiple interactions ISO PPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A] CTD PMID:14641110 NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A] CTD PMID:14641110 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
manumycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP manumycin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:19002579 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO manumycin results in increased activity of CASP3
[Quercetin co-treated with manumycin] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [manumycin results in increased activity of CASP3]
CTD PMID:14625852 PMID:19409983 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO manumycin inhibits the reaction [Plant Extracts results in decreased expression of CCNB1 mRNA] CTD PMID:25051199 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of CCND1 protein] CTD PMID:19409983 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO manumycin inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA] CTD PMID:25051199 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of CDKN1A protein]
manumycin results in increased expression of CDKN1A protein
CTD PMID:19409983 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit multiple interactions ISO manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein] CTD PMID:18450646 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased expression of CYBB mRNA] CTD PMID:19739265 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Enosf1 enolase superfamily member 1 decreases expression
affects localization
ISO manumycin results in decreased expression of ENOSF1 protein
manumycin affects the localization of ENOSF1 protein
CTD PMID:18357371 NCBI chr 9:113,275,267...113,314,842 JBrowse link
G Faslg Fas ligand multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased expression of FASL mRNA] CTD PMID:19739265 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP manumycin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; manumycin inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA] CTD PMID:16572112 PMID:17635749 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein] CTD PMID:18450646 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [manumycin results in increased phosphorylation of H2AX protein] CTD PMID:19409983 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
decreases expression
ISO
EXP
manumycin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein]
manumycin inhibits the reaction [Glucose results in increased activity of HRAS protein]; manumycin inhibits the reaction [INS1 protein results in increased farnesylation of HRAS protein]
manumycin results in decreased expression of HRAS protein
CTD PMID:16572112 PMID:19002579 PMID:19739265 PMID:19958823 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ifng interferon gamma multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA]; manumycin inhibits the reaction [Acetaminophen results in increased expression of IFNG protein] CTD PMID:19739265 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il18 interleukin 18 multiple interactions ISO geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]
manumycin results in decreased susceptibility to IL1B protein
CTD PMID:21211511 PMID:21430599 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Ins1 insulin 1 multiple interactions EXP manumycin inhibits the reaction [INS1 protein results in increased expression of RASGRF1 protein]; manumycin inhibits the reaction [INS1 protein results in increased farnesylation of HRAS protein]; manumycin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:19002579 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
decreases activity
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased activity of KRAS protein] CTD PMID:19409983 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:21575692 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:19739265 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:19739265 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:21211511 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mras muscle RAS oncogene homolog multiple interactions EXP manumycin inhibits the reaction [Glucose results in increased activity of MRAS protein] CTD PMID:18569938 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO manumycin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; manumycin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein] CTD PMID:19739265 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO manumycin results in increased cleavage of PARP1; manumycin results in increased cleavage of PARP1 protein
Acetylcysteine inhibits the reaction [manumycin results in increased cleavage of PARP1]; Quercetin promotes the reaction [manumycin results in increased cleavage of PARP1 protein]
CTD PMID:14625852 PMID:19409983 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions EXP manumycin inhibits the reaction [Streptozocin results in increased expression of RAF1 protein]; manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein] CTD PMID:18569938 PMID:21575692 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 multiple interactions EXP manumycin inhibits the reaction [INS1 protein results in increased expression of RASGRF1 protein] CTD PMID:19002579 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of SOD1] CTD PMID:19409983 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased phosphorylation of STAT3 protein] CTD PMID:19409983 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TERT protein] CTD PMID:19409983 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP manumycin inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA] CTD PMID:16572112 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; manumycin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; manumycin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]
manumycin results in decreased susceptibility to TNF protein
CTD PMID:19739265 PMID:21211511 PMID:21430599 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnpo1 transportin 1 multiple interactions ISO Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TNPO1] CTD PMID:19409983 NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375
JBrowse link
G Txn1 thioredoxin 1 decreases expression ISO manumycin results in decreased expression of TXN CTD PMID:19409983 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP manumycin inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; manumycin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:18569938 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
marimastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin multiple interactions ISO marimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of AREG protein] CTD PMID:15342401 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO marimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of AREG protein]; marimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of TGFA protein] CTD PMID:15342401 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP marimastat inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein] CTD PMID:15574683 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP marimastat inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein] CTD PMID:15574683 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP marimastat inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK8 protein] CTD PMID:15574683 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO marimastat inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein] CTD PMID:22340517 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO marimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of TGFA protein] CTD PMID:15342401 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
methacrylyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Echs1 enoyl-CoA hydratase, short chain 1 increases abundance ISO ECHS1 gene mutant form results in increased abundance of methacrylyl-coenzyme A CTD PMID:25125611 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase increases abundance ISO HIBCH gene mutant form results in increased abundance of methacrylyl-coenzyme A CTD PMID:25125611 NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824
JBrowse link
mocetinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule increases expression ISO mocetinostat results in increased expression of CD274 protein CTD PMID:26775640 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein] CTD PMID:24200994 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO mocetinostat results in decreased expression of CDCA8 mRNA CTD PMID:26378038 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO mocetinostat results in decreased expression of CDK1 mRNA CTD PMID:26378038 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO mocetinostat results in increased expression of ERRFI1 mRNA CTD PMID:33770205 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Gpr183 G protein-coupled receptor 183 decreases expression ISO mocetinostat results in decreased expression of GPR183 mRNA CTD PMID:33770205 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
JBrowse link
G H3f4 H3.4 histone, cluster member increases acetylation ISO mocetinostat results in increased acetylation of H3-4 protein CTD PMID:19215824 NCBI chr10:43,740,702...43,741,262 JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO mocetinostat results in decreased expression of HDAC1 protein CTD PMID:26378038 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO mocetinostat results in decreased expression of HDAC2 protein CTD PMID:26378038 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO mocetinostat results in decreased expression of HDAC3 protein CTD PMID:26378038 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Ifng interferon gamma multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IFNG protein] CTD PMID:24200994 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL2 protein] CTD PMID:24200994 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL6 protein] CTD PMID:24200994 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [mocetinostat co-treated with (+)-JQ1 compound] results in decreased phosphorylation of MAPK1 protein CTD PMID:26378038 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [mocetinostat co-treated with (+)-JQ1 compound] results in decreased phosphorylation of MAPK3 protein CTD PMID:26378038 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Neu1 neuraminidase 1 decreases expression ISO mocetinostat results in decreased expression of NEU1 mRNA CTD PMID:33770205 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745
JBrowse link
G Potem POTE ankyrin domain family member M increases expression ISO mocetinostat results in increased expression of POTEM mRNA CTD PMID:33770205 NCBI chr16:20,193,646...20,311,924
Ensembl chr16:19,949,230...19,976,541
JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 increases expression ISO mocetinostat results in increased expression of PSD3 mRNA CTD PMID:33770205 NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547
JBrowse link
G Ralgdsl1 ral guanine nucleotide dissociation stimulator like 1 increases expression ISO mocetinostat results in increased expression of RGL1 mRNA CTD PMID:33770205 NCBI chr13:64,634,489...64,904,170
Ensembl chr13:64,635,246...64,904,191
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases acetylation ISO mocetinostat results in increased acetylation of STAT3 protein CTD PMID:26775640 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO mocetinostat results in increased expression of TMCC3 mRNA CTD PMID:33770205 NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of TNF protein] CTD PMID:24200994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpcn1 two pore segment channel 1 increases expression ISO mocetinostat results in increased expression of TPCN1 mRNA CTD PMID:33770205 NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO mocetinostat results in increased expression of UGCG mRNA CTD PMID:33770205 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
molibresib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway decreases response to substance ISO APC mutant form results in decreased susceptibility to molibresib CTD PMID:26367796 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO molibresib results in increased expression of APOA1 mRNA; molibresib results in increased expression of APOA1 protein CTD PMID:21568322 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Car9 carbonic anhydrase 9 decreases expression
multiple interactions
ISO molibresib results in decreased expression of CA9 mRNA
molibresib inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]
CTD PMID:27292261 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Casp3 caspase 3 increases activity ISO molibresib results in increased activity of CASP3 protein CTD PMID:26911376 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO molibresib results in increased activity of CASP7 protein CTD PMID:26911376 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO molibresib results in decreased expression of CCND1 mRNA CTD PMID:24874954 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib] CTD PMID:26367796 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression
multiple interactions
ISO molibresib results in increased expression of EPAS1 mRNA
[Oxygen deficiency co-treated with molibresib] results in increased expression of EPAS1 mRNA
CTD PMID:27292261 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO molibresib results in decreased expression of ESR1 mRNA CTD PMID:24874954 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 decreases expression ISO molibresib results in decreased expression of GREB1 mRNA CTD PMID:24874954 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Ifng interferon gamma multiple interactions ISO molibresib inhibits the reaction [IL15 protein results in increased expression of IFNG protein] CTD PMID:29301935 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il15 interleukin 15 multiple interactions ISO molibresib inhibits the reaction [IL15 protein results in increased expression of IFNG protein] CTD PMID:29301935 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions
decreases response to substance
ISO DKK1 protein inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib]; pyrvinium inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib] CTD PMID:26367796 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Lox lysyl oxidase multiple interactions
decreases expression
ISO molibresib inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]
molibresib results in decreased expression of LOX mRNA
CTD PMID:27292261 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO molibresib inhibits the reaction [Oxygen deficiency results in increased expression of MYC mRNA] CTD PMID:27292261 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression
multiple interactions
ISO molibresib results in increased expression of PFKFB3 mRNA
molibresib promotes the reaction [Oxygen deficiency results in increased expression of PFKFB3 mRNA]
CTD PMID:27292261 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO molibresib results in decreased expression of TFF1 mRNA CTD PMID:24874954 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tmem45a transmembrane protein 45A multiple interactions ISO molibresib inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA] CTD PMID:27292261 NCBI chr11:43,713,309...43,799,526
Ensembl chr11:43,713,782...43,799,526
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO molibresib results in decreased expression of VEGFA mRNA
molibresib inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]
CTD PMID:27292261 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
myristoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbi diazepam binding inhibitor affects binding ISO S-tetradecanoyl-coenzyme A binds to DBI protein CTD PMID:17044054 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO S-tetradecanoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO S-tetradecanoyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects response to substance
affects binding
multiple interactions
ISO
EXP
DRD2 promoter polymorphism affects the susceptibility to nemonapride
nemonapride binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]; Flunarizine inhibits the reaction [nemonapride binds to DRD2 protein]
CTD PMID:7503767 PMID:11505224 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd4 dopamine receptor D4 affects binding ISO nemonapride binds to DRD4 protein CTD PMID:31323226 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
N-(p-amylcinnamoyl)anthranilic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]
CTD PMID:33309544 PMID:35395232 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP8 protein]] CTD PMID:35395232 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]
CTD PMID:33309544 PMID:35395232 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Slc13a2 solute carrier family 13 member 2 multiple interactions ISO [4-amylcinnamoylanthranilic acid results in decreased activity of SLC13A2 protein] which results in decreased susceptibility to diethylene glycol metabolite CTD PMID:21856646 NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions
decreases activity
ISO
EXP
4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]]
4-amylcinnamoylanthranilic acid results in decreased activity of TRPM2 protein
4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
CTD PMID:18204483 PMID:30229906 PMID:33309544 PMID:34958835 PMID:35395232 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
N-acetyldopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase affects binding ISO N-acetyldopamine binds to MTHFS protein CTD PMID:17055997 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089
JBrowse link
N-benzoyl-L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]; N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding
ISO N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein]
N-benzoylalanine binds to THRB protein
CTD PMID:31566444 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
N-benzoylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO hippuric acid promotes the reaction [ABCC3 protein results in increased uptake of Taurocholic Acid] CTD PMID:30639138 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO hippuric acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate] CTD PMID:21483698 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO hippuric acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate] CTD PMID:21483698 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of hippuric acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression ISO hippuric acid results in increased expression of SLC10A1 mRNA CTD PMID:30639138 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
N-Methylolacrylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO N-methylolacrylamide results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO N-methylolacrylamide results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO N-methylolacrylamide results in decreased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO N-methylolacrylamide results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO N-methylolacrylamide results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO N-methylolacrylamide results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
N-oleoyldopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 multiple interactions EXP N-oleoyldopamine binds to and results in increased activity of CNR1 protein CTD PMID:12569099 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO N-oleoyldopamine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27936102 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO N-oleoyldopamine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27936102 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity
ISO
EXP
3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [N-oleoyldopamine promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; [N-oleoyldopamine results in increased activity of TRPV1 protein] which results in increased uptake of Calcium; iodoresiniferatoxin inhibits the reaction [[N-oleoyldopamine results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; iodoresiniferatoxin inhibits the reaction [N-oleoyldopamine results in increased activity of TRPV1 protein] CTD PMID:12569099 PMID:15615864 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
niclosamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1bg alpha-1-B glycoprotein increases expression ISO Niclosamide results in increased expression of A1BG mRNA CTD PMID:36318118 NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097
JBrowse link
G Abca12 ATP binding cassette subfamily A member 12 decreases expression ISO Niclosamide results in decreased expression of ABCA12 mRNA CTD PMID:36318118 NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression ISO Niclosamide results in decreased expression of ABCC9 mRNA CTD PMID:36318118 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 increases expression ISO Niclosamide results in increased expression of ABCG4 mRNA CTD PMID:36318118 NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881
JBrowse link
G Abhd1 abhydrolase domain containing 1 increases expression ISO Niclosamide results in increased expression of ABHD1 mRNA CTD PMID:36318118 NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514
JBrowse link
G Abhd14b abhydrolase domain containing 14b increases expression ISO Niclosamide results in increased expression of ABHD14B mRNA CTD PMID:36318118 NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Niclosamide results in decreased expression of ACACA mRNA CTD PMID:22576131 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]
CTD PMID:26792726 PMID:28824321 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Niclosamide results in decreased expression of ACSL1 mRNA CTD PMID:22576131 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]
Niclosamide results in decreased expression of ACTA2 protein
Niclosamide results in decreased expression of ACTA2 mRNA; Niclosamide results in decreased expression of ACTA2 protein
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of ACTA2 protein]
CTD PMID:26643609 PMID:28318631 PMID:34118929 PMID:35115509 PMID:36870549 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adamts17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 decreases expression ISO Niclosamide results in decreased expression of ADAMTS17 mRNA CTD PMID:36318118 NCBI chr 1:120,445,800...120,768,204
Ensembl chr 1:120,445,749...120,768,202
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Niclosamide results in decreased expression of ADH4 mRNA CTD PMID:28284560 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adm2 adrenomedullin 2 increases expression ISO Niclosamide results in increased expression of ADM2 mRNA CTD PMID:36318118 NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331
JBrowse link
G Adra2a adrenoceptor alpha 2A decreases expression ISO Niclosamide results in decreased expression of ADRA2A mRNA CTD PMID:36318118 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]] CTD PMID:32961231 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agbl3 AGBL carboxypeptidase 3 decreases expression ISO Niclosamide results in decreased expression of AGBL3 mRNA CTD PMID:36318118 NCBI chr 4:63,448,789...63,535,538
Ensembl chr 4:63,453,940...63,531,188
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases cleavage ISO Niclosamide results in increased cleavage of AIFM1 protein CTD PMID:22576131 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akna AT-hook transcription factor increases expression ISO Niclosamide results in increased expression of AKNA mRNA CTD PMID:36318118 NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions
ISO Niclosamide results in increased expression of AKT1 mRNA
Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:20215516 PMID:26792726 PMID:29843133 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Niclosamide results in decreased expression of ALDH1A1 protein CTD PMID:24736023 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO Niclosamide results in increased expression of ALDH6A1 mRNA CTD PMID:36318118 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression ISO Niclosamide results in increased expression of ALDOB mRNA CTD PMID:22576131 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression
increases expression
ISO Niclosamide results in decreased expression of ALDOC mRNA
Niclosamide results in increased expression of ALDOC mRNA
CTD PMID:22576131 PMID:36318118 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alkbh7 alkB homolog 7 increases expression ISO Niclosamide results in increased expression of ALKBH7 mRNA CTD PMID:36318118 NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044
JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type increases expression
multiple interactions
decreases response to substance
ISO Niclosamide results in increased expression of ALOX12B mRNA
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]
ALOX12B protein results in decreased susceptibility to Niclosamide
CTD PMID:30258081 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases response to substance
increases expression
ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]
ALOX5 protein results in decreased susceptibility to Niclosamide
CTD PMID:30258081 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression ISO Niclosamide results in decreased expression of ALPL mRNA CTD PMID:28824321 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 increases expression ISO Niclosamide results in increased expression of AMHR2 mRNA CTD PMID:36318118 NCBI chr 7:133,579,152...133,588,874
Ensembl chr 7:133,579,393...133,588,258
JBrowse link
G Amot angiomotin increases expression ISO Niclosamide results in increased expression of AMOT mRNA CTD PMID:36318118 NCBI chr  X:108,982,399...109,041,265
Ensembl chr  X:108,984,022...109,041,272
JBrowse link
G Ank3 ankyrin 3 increases expression ISO Niclosamide results in increased expression of ANK3 mRNA CTD PMID:36318118 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Ankmy2 ankyrin repeat and MYND domain containing 2 increases expression ISO Niclosamide results in increased expression of ANKMY2 mRNA CTD PMID:36318118 NCBI chr 6:52,888,959...52,930,343
Ensembl chr 6:52,888,963...52,930,394
JBrowse link
G Ankrd12 ankyrin repeat domain 12 increases expression ISO Niclosamide results in increased expression of ANKRD12 mRNA CTD PMID:36318118 NCBI chr 9:105,583,273...105,687,957
Ensembl chr 9:105,584,065...105,687,911
JBrowse link
G Ankrd34a ankyrin repeat domain 34A increases expression ISO Niclosamide results in increased expression of ANKRD34A mRNA CTD PMID:36318118 NCBI chr 2:184,129,830...184,135,075
Ensembl chr 2:184,129,238...184,135,116
JBrowse link
G Anxa4 annexin A4 increases expression ISO Niclosamide results in increased expression of ANXA4 mRNA CTD PMID:36318118 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Ap1s3 adaptor related protein complex 1 subunit sigma 3 decreases expression ISO Niclosamide results in decreased expression of AP1S3 mRNA CTD PMID:36318118 NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798
JBrowse link
G Aplnr apelin receptor decreases expression ISO Niclosamide results in decreased expression of APLNR mRNA CTD PMID:36318118 NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
JBrowse link
G Apof apolipoprotein F decreases expression ISO Niclosamide results in decreased expression of APOF mRNA CTD PMID:28284560 NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO [enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form
Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form
CTD PMID:24740322 PMID:25970160 PMID:28500234 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein CTD PMID:28284560 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta increases expression ISO Niclosamide results in increased expression of ARHGDIB mRNA CTD PMID:36318118 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression ISO Niclosamide results in increased expression of ARMCX1 mRNA CTD PMID:36318118 NCBI chr  X:97,898,969...97,902,874
Ensembl chr  X:97,898,883...97,903,299
JBrowse link
G Arrdc2 arrestin domain containing 2 increases expression ISO Niclosamide results in increased expression of ARRDC2 mRNA CTD PMID:36318118 NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression ISO Niclosamide results in decreased expression of ASF1B mRNA CTD PMID:28284560 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
JBrowse link
G Atcay ATCAY kinesin light chain interacting caytaxin increases expression ISO Niclosamide results in increased expression of ATCAY mRNA CTD PMID:36318118 NCBI chr 7:8,487,763...8,511,527
Ensembl chr 7:8,487,763...8,512,663
JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions
ISO Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]
CTD PMID:26917416 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein CTD PMID:26917416 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atosb atos homolog B increases expression ISO Niclosamide results in increased expression of ATOSB mRNA CTD PMID:36318118 NCBI chr 5:57,260,839...57,274,524
Ensembl chr 5:57,260,841...57,268,892
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 increases expression ISO Niclosamide results in increased expression of ATP2A3 mRNA CTD PMID:36318118 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO Niclosamide results in increased expression of ATP5F1A mRNA CTD PMID:22576131 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta increases expression ISO Niclosamide results in increased expression of ATP5F1D mRNA CTD PMID:22576131 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 decreases expression ISO Niclosamide results in decreased expression of ATP5MC3 mRNA CTD PMID:22576131 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Niclosamide results in decreased expression of ATP5MF mRNA CTD PMID:22576131 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
JBrowse link
G Atp5mg ATP synthase membrane subunit G decreases expression ISO Niclosamide results in decreased expression of ATP5MG mRNA CTD PMID:22576131 NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b decreases expression ISO Niclosamide results in decreased expression of ATP5PB mRNA CTD PMID:22576131 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 decreases expression ISO Niclosamide results in decreased expression of ATP6AP1 mRNA CTD PMID:22576131 NCBI chr  X:152,079,954...152,087,034
Ensembl chr  X:152,079,865...152,087,034
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] CTD PMID:26792726 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Atpsckmt ATP synthase c subunit lysine N-methyltransferase decreases expression ISO Niclosamide results in decreased expression of ATPSCKMT mRNA CTD PMID:36318118 NCBI chr 2:82,603,086...82,618,325
Ensembl chr 2:82,603,009...82,618,308
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Niclosamide results in decreased expression of AURKB mRNA CTD PMID:28284560 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Avpi1 arginine vasopressin-induced 1 increases expression ISO Niclosamide results in increased expression of AVPI1 mRNA CTD PMID:36318118 NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154
JBrowse link
G Axin2 axin 2 multiple interactions
decreases expression
ISO Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]
Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein
CTD PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G B3gnt7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 increases expression ISO Niclosamide results in increased expression of B3GNT7 mRNA CTD PMID:36318118 NCBI chr 9:86,956,220...86,960,171
Ensembl chr 9:86,956,220...86,960,170
JBrowse link
G B3gnt9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 increases expression ISO Niclosamide results in increased expression of B3GNT9 mRNA CTD PMID:36318118 NCBI chr19:33,129,740...33,134,048
Ensembl chr19:33,128,142...33,132,344
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA CTD PMID:25988281 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA CTD PMID:25988281 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO Niclosamide results in increased expression of BAX protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]
CTD PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234 PMID:35115509 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression
ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA] CTD PMID:30258081 PMID:36318118 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 increases expression ISO Niclosamide results in increased expression of BBS2 mRNA CTD PMID:36318118 NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]
CTD PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO [Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein
CTD PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression
multiple interactions
ISO Niclosamide results in decreased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]
CTD PMID:23894143 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Niclosamide results in increased expression of BCL3 mRNA CTD PMID:36318118 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions
increases expression
ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]
Niclosamide results in increased expression of BCL6 mRNA
CTD PMID:33632240 PMID:36318118 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bcl6b BCL6B, transcription repressor increases expression ISO Niclosamide results in increased expression of BCL6B mRNA CTD PMID:36318118 NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974
JBrowse link
G Bcl9 BCL9, transcription coactivator decreases expression EXP Niclosamide results in decreased expression of BCL9 mRNA CTD PMID:27338550 NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435
JBrowse link
G Bcorl1 BCL6 co-repressor-like 1 increases expression ISO Niclosamide results in increased expression of BCORL1 mRNA CTD PMID:36318118 NCBI chr  X:127,516,504...127,584,529
Ensembl chr  X:127,537,538...127,584,087
JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like increases expression ISO Niclosamide results in increased expression of BET1L mRNA CTD PMID:36318118 NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040
JBrowse link
G Bgn biglycan increases expression ISO Niclosamide results in increased expression of BGN mRNA CTD PMID:36318118 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Niclosamide results in increased expression of BHLHE40 mRNA CTD PMID:36318118 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
affects expression
decreases expression
ISO enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]
Niclosamide affects the expression of BIRC5 protein
Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 mRNA; Niclosamide results in decreased expression of BIRC5 protein
CTD PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234 More... NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmf Bcl2 modifying factor increases expression ISO Niclosamide results in increased expression of BMF mRNA CTD PMID:36318118 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Borcs6 BLOC-1 related complex subunit 6 increases expression ISO Niclosamide results in increased expression of BORCS6 mRNA CTD PMID:36318118 NCBI chr10:53,760,504...53,762,358
Ensembl chr10:53,758,093...53,762,632
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression
decreases phosphorylation
ISO Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein
Niclosamide analog results in decreased phosphorylation of BRAF protein
CTD PMID:28284560 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Btbd7 BTB domain containing 7 decreases expression ISO Niclosamide results in decreased expression of BTBD7 mRNA CTD PMID:36318118 NCBI chr 6:121,920,365...122,010,114
Ensembl chr 6:121,923,023...121,972,405
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Niclosamide results in increased expression of BTG2 mRNA CTD PMID:36318118 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G C13h1orf105 similar to human chromosome 1 open reading frame 105 decreases expression ISO Niclosamide results in decreased expression of C1ORF105 mRNA CTD PMID:36318118 NCBI chr13:74,313,320...74,356,322
Ensembl chr13:74,313,322...74,356,322
JBrowse link
G C16h8orf48 similar to human chromosome 8 open reading frame 48 decreases expression ISO Niclosamide results in decreased expression of C8ORF48 mRNA CTD PMID:36318118 NCBI chr16:55,244,744...55,246,642
Ensembl chr16:55,236,322...55,246,650
JBrowse link
G C19h16orf86 similar to human chromosome 16 open reading frame 86 increases expression ISO Niclosamide results in increased expression of C16ORF86 mRNA CTD PMID:36318118 NCBI chr19:33,596,591...33,598,703
Ensembl chr19:33,595,995...33,598,521
JBrowse link
G C1ql4 complement C1q like 4 increases expression ISO Niclosamide results in increased expression of C1QL4 mRNA CTD PMID:36318118 NCBI chr 7:130,243,606...130,246,678
Ensembl chr 7:130,243,606...130,246,678
JBrowse link
G Cables2 Cdk5 and Abl enzyme substrate 2 decreases expression ISO Niclosamide results in decreased expression of CABLES2 mRNA CTD PMID:36318118 NCBI chr 3:167,347,527...167,362,274
Ensembl chr 3:167,347,461...167,362,279
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E increases expression ISO Niclosamide results in increased expression of CACNA1E mRNA CTD PMID:36318118 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression ISO Niclosamide results in increased expression of CACNA1H mRNA CTD PMID:36318118 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 increases expression ISO Niclosamide results in increased expression of CACNG1 mRNA CTD PMID:36318118 NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO Niclosamide results in increased expression of CAMK2A mRNA CTD PMID:36318118 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camsap3 calmodulin regulated spectrin-associated protein family, member 3 increases expression ISO Niclosamide results in increased expression of CAMSAP3 mRNA CTD PMID:36318118 NCBI chr12:1,643,062...1,666,685
Ensembl chr12:1,643,251...1,666,685
JBrowse link
G Caps calcyphosine increases expression ISO Niclosamide results in increased expression of CAPS mRNA CTD PMID:36318118 NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]
CTD PMID:33524445 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
decreases expression
ISO
EXP
Niclosamide results in increased cleavage of CASP3 protein
Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]
Niclosamide results in increased expression of CASP3 protein modified form
Niclosamide results in decreased expression of CASP3 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]
CTD PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
ISO bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form] CTD PMID:26116531 PMID:28500234 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Niclosamide results in increased cleavage of CASP8 protein CTD PMID:35115509 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases cleavage
ISO TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]
Niclosamide results in increased expression of CASP9 mRNA; Niclosamide results in increased expression of CASP9 protein modified form
CTD PMID:26116531 PMID:26703449 PMID:30258081 PMID:36318118 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cbx4 chromobox 4 increases expression ISO Niclosamide results in increased expression of CBX4 mRNA CTD PMID:36318118 NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706
JBrowse link
G Ccdc113 coiled-coil domain containing 113 increases expression ISO Niclosamide results in increased expression of CFAP263 mRNA CTD PMID:36318118 NCBI chr19:9,497,000...9,516,917
Ensembl chr19:9,496,886...9,516,923
JBrowse link
G Ccdc188 coiled-coil domain containing 188 increases expression ISO Niclosamide results in increased expression of CCDC188 mRNA CTD PMID:36318118 NCBI chr11:82,769,735...82,772,062
Ensembl chr11:82,769,473...82,772,114
JBrowse link
G Ccdc68 coiled-coil domain containing 68 decreases expression ISO Niclosamide results in decreased expression of CCDC68 mRNA CTD PMID:36318118 NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]
CTD PMID:24561310 PMID:28318631 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO
EXP
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]
CTD PMID:28318631 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:24561310 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein] CTD PMID:24561310 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Niclosamide results in decreased expression of CCNB1 mRNA CTD PMID:28284560 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb3 cyclin B3 decreases expression ISO Niclosamide results in decreased expression of CCNB3 mRNA CTD PMID:36318118 NCBI chr  X:15,478,050...15,543,292
Ensembl chr  X:15,478,065...15,542,885
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP
ISO
Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]]
Niclosamide results in decreased expression of CCND1 mRNA
Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein
Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein]
CTD PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 decreases expression
increases expression
ISO Niclosamide results in decreased expression of CCND2 mRNA
Niclosamide results in increased expression of CCND2 mRNA
CTD PMID:22576131 PMID:27226553 PMID:36318118 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Niclosamide results in decreased expression of CCND3 mRNA CTD PMID:22576131 PMID:27226553 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Niclosamide results in decreased expression of CCNE1 mRNA CTD PMID:36318118 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 multiple interactions
decreases expression
ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]
Niclosamide results in decreased expression of CCNE2 mRNA
CTD PMID:27542212 PMID:36318118 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccng2 cyclin G2 multiple interactions
increases expression
ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]
Niclosamide results in increased expression of CCNG2 mRNA
CTD PMID:27542212 PMID:36318118 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 increases expression ISO Niclosamide results in increased expression of CCR10 mRNA CTD PMID:36318118 NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988
JBrowse link
G Cd27 CD27 molecule increases expression ISO Niclosamide results in increased expression of CD27 mRNA CTD PMID:36318118 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
JBrowse link
G Cd274 CD274 molecule decreases expression ISO Niclosamide results in decreased expression of CD274 mRNA; Niclosamide results in decreased expression of CD274 protein CTD PMID:35115509 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein] CTD PMID:24561310 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Niclosamide results in increased expression of CD55 mRNA CTD PMID:36318118 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cd68 Cd68 molecule increases expression ISO Niclosamide results in increased expression of CD68 mRNA CTD PMID:36318118 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein] CTD PMID:24561310 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein] CTD PMID:24561310 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO CDC37 protein binds to and results in increased susceptibility to Niclosamide analog CTD PMID:28284560 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
JBrowse link
G Cdc42 cell division cycle 42 decreases expression
decreases phosphorylation
ISO Niclosamide results in decreased expression of CDC42 mRNA
Niclosamide results in decreased phosphorylation of CDC42 protein
CTD PMID:29251334 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdc42ep1 CDC42 effector protein 1 increases expression ISO Niclosamide results in increased expression of CDC42EP1 mRNA CTD PMID:36318118 NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Niclosamide results in decreased expression of CDC6 mRNA CTD PMID:28284560 PMID:36318118 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdca2 cell division cycle associated 2 decreases expression ISO Niclosamide results in decreased expression of CDCA2 mRNA CTD PMID:28284560 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
JBrowse link
G Cdca5 cell division cycle associated 5 decreases expression ISO Niclosamide results in decreased expression of CDCA5 mRNA CTD PMID:28284560 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO Niclosamide results in decreased expression of CDCA8 mRNA CTD PMID:28284560 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]
Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein
CTD PMID:25174399 PMID:26643609 PMID:30143678 PMID:35115509 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO Niclosamide results in decreased expression of CDH11 mRNA CTD PMID:36318118 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdh12 cadherin 12 multiple interactions ISO Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CDH12 protein] CTD PMID:36870549 NCBI chr 2:70,474,679...71,705,369
Ensembl chr 2:70,475,043...71,700,572
JBrowse link
G Cdh2 cadherin 2 multiple interactions
decreases expression
ISO Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein]
Niclosamide results in decreased expression of CDH2 protein
CTD PMID:26643609 PMID:34118929 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdh4 cadherin 4 increases expression ISO Niclosamide results in increased expression of CDH4 mRNA CTD PMID:36318118 NCBI chr 3:166,525,092...167,003,380
Ensembl chr 3:166,525,099...167,003,371
JBrowse link
G Cdh6 cadherin 6 decreases expression ISO Niclosamide results in decreased expression of CDH6 mRNA CTD PMID:36318118 NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228
JBrowse link
G Cdhr1 cadherin-related family member 1 increases expression ISO Niclosamide results in increased expression of CDHR1 mRNA CTD PMID:36318118 NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396
JBrowse link
G Cdhr2 cadherin-related family member 2 decreases expression ISO Niclosamide results in decreased expression of CDHR2 mRNA CTD PMID:36318118 NCBI chr17:9,876,853...9,913,356
Ensembl chr17:9,876,860...9,912,575
JBrowse link
G Cdk15 cyclin-dependent kinase 15 decreases expression ISO Niclosamide results in decreased expression of CDK15 mRNA CTD PMID:36318118 NCBI chr 9:60,710,787...60,803,638
Ensembl chr 9:60,711,715...60,802,777
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Niclosamide results in decreased expression of CDK2 protein CTD PMID:29031202 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Niclosamide results in decreased expression of CDK4 protein CTD PMID:29031202 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkl3 cyclin-dependent kinase-like 3 increases expression ISO Niclosamide results in increased expression of CDKL3 mRNA CTD PMID:36318118 NCBI chr10:36,263,212...36,349,268
Ensembl chr10:36,266,977...36,349,268
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA] CTD PMID:30258081 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO Niclosamide results in decreased expression of CDKN3 mRNA CTD PMID:28284560 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Niclosamide results in increased expression of CEBPB mRNA CTD PMID:36318118 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Celf6 CUGBP, Elav-like family member 6 increases expression ISO Niclosamide results in increased expression of CELF6 mRNA CTD PMID:36318118 NCBI chr 8:59,975,095...60,006,060
Ensembl chr 8:59,975,088...60,005,041
JBrowse link
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 increases expression ISO Niclosamide results in increased expression of CELSR3 mRNA CTD PMID:28284560 NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
JBrowse link
G Cenpa centromere protein A decreases expression ISO Niclosamide results in decreased expression of CENPA mRNA CTD PMID:28284560 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
JBrowse link
G Cenpo centromere protein O decreases expression ISO Niclosamide results in decreased expression of CENPO mRNA CTD PMID:36318118 NCBI chr 6:27,203,642...27,218,394
Ensembl chr 6:27,188,537...27,218,314
JBrowse link
G Cenpu centromere protein U decreases expression ISO Niclosamide results in decreased expression of CENPU mRNA CTD PMID:36318118 NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
JBrowse link
G Cfap70 cilia and flagella associated protein 70 increases expression ISO Niclosamide results in increased expression of CFAP70 mRNA CTD PMID:36318118 NCBI chr15:3,852,381...3,918,036
Ensembl chr15:3,852,509...3,918,014
JBrowse link
G Cfp complement factor properdin increases expression ISO Niclosamide results in increased expression of CFP mRNA CTD PMID:28284560 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Niclosamide results in increased expression of CHAC1 mRNA CTD PMID:36318118 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
JBrowse link
G Chac2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 decreases expression ISO Niclosamide results in decreased expression of CHAC2 mRNA CTD PMID:36318118 NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301
JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO Niclosamide results in decreased expression of CHAF1A mRNA CTD PMID:36318118 NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit increases expression ISO Niclosamide results in increased expression of CHRNB1 mRNA CTD PMID:36318118 NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345
JBrowse link
G Chst8 carbohydrate sulfotransferase 8 increases expression ISO Niclosamide results in increased expression of CHST8 mRNA CTD PMID:36318118 NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein CTD PMID:26116531 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cish cytokine inducible SH2-containing protein increases expression ISO Niclosamide results in increased expression of CISH mRNA CTD PMID:36318118 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Clec11a C-type lectin domain containing 11A increases expression ISO Niclosamide results in increased expression of CLEC11A mRNA CTD PMID:36318118 NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633
JBrowse link
G Clip2 CAP-GLY domain containing linker protein 2 increases expression ISO Niclosamide results in increased expression of CLIP2 mRNA CTD PMID:36318118 NCBI chr12:22,163,044...22,227,023
Ensembl chr12:22,163,218...22,227,023
JBrowse link
G Clip3 CAP-GLY domain containing linker protein 3 increases expression ISO Niclosamide results in increased expression of CLIP3 mRNA CTD PMID:36318118 NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184
JBrowse link
G Clspn claspin decreases expression ISO Niclosamide results in decreased expression of CLSPN mRNA CTD PMID:36318118 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Clstn3 calsyntenin 3 increases expression ISO Niclosamide results in increased expression of CLSTN3 mRNA CTD PMID:36318118 NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769
JBrowse link
G Cmklr1 chemerin chemokine-like receptor 1 decreases expression ISO Niclosamide results in decreased expression of CMKLR1 mRNA CTD PMID:36318118 NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 decreases expression ISO Niclosamide results in decreased expression of CMPK2 mRNA CTD PMID:36318118 NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
JBrowse link
G Cnbd2 cyclic nucleotide binding domain containing 2 increases expression ISO Niclosamide results in increased expression of CNBD2 mRNA CTD PMID:36318118 NCBI chr 3:144,819,166...144,884,825
Ensembl chr 3:144,819,195...144,901,583
JBrowse link
G Cnn1 calponin 1 increases expression ISO Niclosamide results in increased expression of CNN1 mRNA CTD PMID:36318118 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098
JBrowse link
G Cnn2 calponin 2 increases expression ISO Niclosamide results in increased expression of CNN2 mRNA CTD PMID:36318118 NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions
ISO Niclosamide results in decreased expression of COL1A1 mRNA
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Gemcitabine inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Niclosamide inhibits the reaction [Gemcitabine results in decreased expression of COL1A1 protein]
CTD PMID:28824321 PMID:35115509 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO Niclosamide results in increased expression of COL6A2 mRNA CTD PMID:36318118 NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
JBrowse link
G Colec10 collectin subfamily member 10 increases expression ISO Niclosamide results in increased expression of COLEC10 mRNA CTD PMID:28284560 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675
JBrowse link
G Cox8c cytochrome c oxidase subunit 8C increases expression ISO Niclosamide results in increased expression of COX8C mRNA CTD PMID:36318118 NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889
JBrowse link
G Crb2 crumbs cell polarity complex component 2 increases expression ISO Niclosamide results in increased expression of CRB2 mRNA CTD PMID:36318118 NCBI chr 3:21,542,138...21,564,876
Ensembl chr 3:21,542,221...21,563,294
JBrowse link
G Crebbp CREB binding protein increases expression ISO Niclosamide results in increased expression of CREBBP mRNA CTD PMID:22576131 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crebrf CREB3 regulatory factor increases expression ISO Niclosamide results in increased expression of CREBRF mRNA CTD PMID:36318118 NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999
JBrowse link
G Crlf1 cytokine receptor-like factor 1 decreases expression ISO Niclosamide results in decreased expression of CRLF1 mRNA CTD PMID:36318118 NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997
JBrowse link
G Crot carnitine O-octanoyltransferase decreases expression ISO Niclosamide results in decreased expression of CROT mRNA CTD PMID:36318118 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
JBrowse link
G Crybb1 crystallin, beta B1 increases expression ISO Niclosamide results in increased expression of CRYBB1 mRNA CTD PMID:36318118 NCBI chr12:44,369,734...44,383,344
Ensembl chr12:44,369,735...44,383,344
JBrowse link
G Cryl1 crystallin, lambda 1 increases expression ISO Niclosamide results in increased expression of CRYL1 mRNA CTD PMID:36318118 NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein] CTD PMID:28824321 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA] CTD PMID:27542212 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
JBrowse link
G Csnk1e casein kinase 1, epsilon increases expression ISO Niclosamide results in increased expression of CSNK1E mRNA CTD PMID:22576131 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 increases expression ISO Niclosamide results in increased expression of CSRNP1 mRNA CTD PMID:28284560 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
JBrowse link
G Ctbp1 C-terminal binding protein 1 increases expression ISO Niclosamide results in increased expression of CTBP1 mRNA CTD PMID:22576131 NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
affects localization
decreases expression
increases ubiquitination
decreases activity
multiple interactions
ISO
EXP
Niclosamide results in increased expression of CTNNB1 mRNA
Niclosamide affects the localization of CTNNB1 protein
Niclosamide results in decreased expression of CTNNB1 mRNA
Niclosamide results in increased ubiquitination of CTNNB1 protein
Niclosamide results in decreased activity of CTNNB1 protein
Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]
Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]; Niclosamide results in decreased expression of and results in increased phosphorylation of CTNNB1 protein
CTD PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 multiple interactions
increases expression
ISO Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]
Niclosamide results in increased expression of CTNNBIP1 mRNA
CTD PMID:24534281 PMID:36318118 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939
JBrowse link
G Ctsc cathepsin C decreases expression ISO Niclosamide results in decreased expression of CTSC protein CTD PMID:29480568 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Ctsd cathepsin D decreases expression ISO Niclosamide results in decreased expression of CTSD protein CTD PMID:29480568 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:26792726 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Niclosamide results in decreased expression of CXCL12 mRNA CTD PMID:36318118 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 multiple interactions ISO Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA] CTD PMID:33632240 NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893
JBrowse link
G Cyb561 cytochrome b-561 decreases expression ISO Niclosamide results in decreased expression of CYB561 mRNA CTD PMID:36318118 NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Niclosamide results in increased expression of CYCS protein CTD PMID:26703449 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO Niclosamide results in increased activity of CYP1A1 protein CTD PMID:12451431 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression
ISO Niclosamide results in decreased activity of CYP1A2 protein
Niclosamide results in increased expression of CYP1A2 mRNA
CTD PMID:11124226 PMID:28284560 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Niclosamide results in increased expression of CYP27A1 mRNA CTD PMID:36318118 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Niclosamide results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Niclosamide results in increased expression of CYP39A1 mRNA CTD PMID:28284560 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Niclosamide results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dact3 dishevelled-binding antagonist of beta-catenin 3 increases expression ISO Niclosamide results in increased expression of DACT3 mRNA CTD PMID:36318118 NCBI chr 1:77,546,900...77,558,631
Ensembl chr 1:77,546,900...77,558,630
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression ISO Niclosamide results in increased expression of DBP mRNA CTD PMID:36318118 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent increases expression ISO Niclosamide results in increased expression of DDAH2 mRNA CTD PMID:36318118 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
JBrowse link
G Ddias DNA damage-induced apoptosis suppressor decreases expression ISO Niclosamide results in decreased expression of DDIAS mRNA CTD PMID:36318118 NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein
ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]
CTD PMID:26917416 PMID:36318118 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Niclosamide results in increased expression of DDIT4 mRNA CTD PMID:36318118 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 increases expression ISO Niclosamide results in increased expression of DDR1 mRNA CTD PMID:36318118 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 decreases expression ISO Niclosamide results in decreased expression of DECR1 mRNA CTD PMID:22576131 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit decreases expression ISO Niclosamide results in decreased expression of DGCR8 mRNA CTD PMID:36318118 NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242
JBrowse link
G Dgkb diacylglycerol kinase, beta increases expression ISO Niclosamide results in increased expression of DGKB mRNA CTD PMID:36318118 NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043
JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO Niclosamide results in decreased expression of DHFR mRNA CTD PMID:36318118 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Niclosamide results in increased expression of DHRS3 mRNA CTD PMID:36318118 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression ISO Niclosamide results in decreased expression of DKK1 mRNA CTD PMID:36318118 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 increases expression ISO Niclosamide results in increased expression of DLG4 mRNA CTD PMID:36318118 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dmac2l distal membrane arm assembly component 2 like decreases expression ISO Niclosamide results in decreased expression of DMAC2L mRNA CTD PMID:22576131 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression ISO Niclosamide results in decreased expression of DNAJA1 mRNA CTD PMID:36318118 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dnaja4 DnaJ heat shock protein family (Hsp40) member A4 decreases expression ISO Niclosamide results in decreased expression of DNAJA4 mRNA CTD PMID:36318118 NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207
JBrowse link
G Dnajc22 DnaJ heat shock protein family (Hsp40) member C22 increases expression ISO Niclosamide results in increased expression of DNAJC22 mRNA CTD PMID:36318118 NCBI chr 7:130,257,504...130,262,880
Ensembl chr 7:130,257,851...130,263,230
JBrowse link
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 decreases expression ISO Niclosamide results in decreased expression of DNAJC9 mRNA CTD PMID:36318118 NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118
JBrowse link
G Dock5 dedicator of cytokinesis 5 decreases expression ISO Niclosamide results in decreased expression of DOCK5 mRNA CTD PMID:36318118 NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649
JBrowse link
G Dqx1 DEAQ box RNA-dependent ATPase 1 increases expression ISO Niclosamide results in increased expression of DQX1 mRNA CTD PMID:36318118 NCBI chr 4:115,563,497...115,572,598
Ensembl chr 4:115,563,752...115,572,590
JBrowse link
G Drd4 dopamine receptor D4 increases expression ISO Niclosamide results in increased expression of DRD4 mRNA CTD PMID:36318118 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA] CTD PMID:27542212 NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog decreases expression ISO Niclosamide results in decreased expression of DTL mRNA CTD PMID:36318118 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Niclosamide results in increased expression of DUSP4 mRNA CTD PMID:36318118 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Niclosamide results in increased expression of DUSP8 mRNA CTD PMID:36318118 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
JBrowse link
G Dusp9 dual specificity phosphatase 9 increases expression ISO Niclosamide results in increased expression of DUSP9 mRNA CTD PMID:36318118 NCBI chr  X:151,351,897...151,355,822
Ensembl chr  X:151,351,897...151,355,821
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 increases expression ISO Niclosamide results in increased expression of DVL1 mRNA CTD PMID:22576131 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
multiple interactions
ISO
EXP
Niclosamide results in decreased expression of DVL2 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]
CTD PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression ISO Niclosamide results in increased expression of DVL3 mRNA CTD PMID:22576131 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
JBrowse link
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B increases expression ISO Niclosamide results in increased expression of DYRK1B mRNA CTD PMID:36318118 NCBI chr 1:83,479,168...83,497,011
Ensembl chr 1:83,479,147...83,487,169
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of E2F1 mRNA CTD PMID:29843133 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Niclosamide results in decreased expression of E2F2 mRNA CTD PMID:36318118 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G E2f7 E2F transcription factor 7 decreases expression ISO Niclosamide results in decreased expression of E2F7 mRNA CTD PMID:36318118 NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO Niclosamide results in decreased expression of E2F8 mRNA CTD PMID:28284560 PMID:36318118 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Eaf2 ELL associated factor 2 decreases expression ISO Niclosamide results in decreased expression of EAF2 mRNA CTD PMID:36318118 NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610
JBrowse link
G Ebf1 EBF transcription factor 1 decreases expression ISO Niclosamide results in decreased expression of EBF1 mRNA CTD PMID:27226553 NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665
JBrowse link
G Ebf4 EBF family member 4 increases expression ISO Niclosamide results in increased expression of EBF4 mRNA CTD PMID:36318118 NCBI chr 3:117,498,186...117,566,566
Ensembl chr 3:117,498,319...117,566,566
JBrowse link
G Echdc1 ethylmalonyl-CoA decarboxylase 1 decreases expression ISO Niclosamide results in decreased expression of ECHDC1 mRNA CTD PMID:22576131 NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319
JBrowse link
G Echdc2 enoyl CoA hydratase domain containing 2 decreases expression ISO Niclosamide results in decreased expression of ECHDC2 mRNA CTD PMID:36318118 NCBI chr 5:122,915,874...122,934,860
Ensembl chr 5:122,916,134...122,934,859
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 decreases expression ISO Niclosamide results in decreased expression of ECHS1 mRNA CTD PMID:22576131 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Efna1 ephrin A1 increases expression ISO Niclosamide results in increased expression of EFNA1 mRNA CTD PMID:36318118 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Efna3 ephrin A3 increases expression ISO Niclosamide results in increased expression of EFNA3 mRNA CTD PMID:36318118 NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
JBrowse link
G Efnb3 ephrin B3 increases expression ISO Niclosamide results in increased expression of EFNB3 mRNA CTD PMID:36318118 NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471
JBrowse link
G Egf epidermal growth factor decreases expression
multiple interactions
ISO Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein binds to EGFR protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Niclosamide inhibits the reaction [EGF protein binds to EGFR protein]; Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]
CTD PMID:30779072 PMID:38185387 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions
decreases phosphorylation
ISO Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein binds to EGFR protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Niclosamide inhibits the reaction [EGF protein binds to EGFR protein]
Niclosamide results in decreased phosphorylation of EGFR protein
CTD PMID:28284560 PMID:28426875 PMID:30779072 PMID:38185387 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
ISO Niclosamide results in increased expression of EGR1 mRNA
Niclosamide results in decreased expression of EGR1 mRNA
CTD PMID:28284560 PMID:36318118 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions
ISO Niclosamide results in increased expression of EIF2AK3 mRNA
ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein
CTD PMID:26917416 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Niclosamide results in increased phosphorylation of EIF2S1 protein CTD PMID:26917416 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 increases expression ISO Niclosamide results in increased expression of EIF4A2 mRNA CTD PMID:36318118 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
multiple interactions
decreases phosphorylation
ISO Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form
Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
Niclosamide results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:19771169 PMID:28284560 PMID:30258081 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Elf1 E74 like ETS transcription factor 1 increases expression ISO Niclosamide results in increased expression of ELF1 mRNA CTD PMID:36318118 NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
JBrowse link
G Elfn1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 increases expression ISO Niclosamide results in increased expression of ELFN1 mRNA CTD PMID:36318118 NCBI chr12:14,660,049...14,725,709
Ensembl chr12:14,660,083...14,724,580
JBrowse link
G Eml2 EMAP like 2 increases expression ISO Niclosamide results in increased expression of EML2 mRNA CTD PMID:36318118 NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341
JBrowse link
G Endod1 endonuclease domain containing 1 multiple interactions ISO Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA] CTD PMID:27542212 NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892
JBrowse link
G Eng endoglin increases expression ISO Niclosamide results in increased expression of ENG mRNA CTD PMID:36318118 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Eno2 enolase 2 increases expression ISO Niclosamide results in increased expression of ENO2 mRNA CTD PMID:22576131 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Eno3 enolase 3 decreases expression ISO Niclosamide results in decreased expression of ENO3 mRNA CTD PMID:22576131 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Niclosamide results in increased expression of EP300 mRNA CTD PMID:22576131 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:36318118 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epha8 Eph receptor A8 increases expression ISO Niclosamide results in increased expression of EPHA8 mRNA CTD PMID:36318118 NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399
JBrowse link
G Eps8l3 EPS8 like 3 increases expression ISO Niclosamide results in increased expression of EPS8L3 mRNA CTD PMID:28284560 NCBI chr 2:195,514,692...195,528,085
Ensembl chr 2:195,514,692...195,528,085
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase increases expression ISO Niclosamide results in increased expression of ETHE1 mRNA CTD PMID:36318118 NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
JBrowse link
G Eva1b eva-1 homolog B increases expression ISO Niclosamide results in increased expression of EVA1B mRNA CTD PMID:36318118 NCBI chr 5:138,427,088...138,429,602
Ensembl chr 5:138,427,151...138,432,433
JBrowse link
G Exo5 exonuclease 5 decreases expression ISO Niclosamide results in decreased expression of EXO5 mRNA CTD PMID:36318118 NCBI chr 5:134,494,440...134,497,757
Ensembl chr 5:134,493,829...134,497,772
JBrowse link
G Exog exo/endonuclease G decreases expression ISO Niclosamide results in decreased expression of EXOG mRNA CTD PMID:36318118 NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672
JBrowse link
G F10 coagulation factor X increases expression ISO Niclosamide results in increased expression of F10 mRNA CTD PMID:36318118 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F12 coagulation factor XII increases expression ISO Niclosamide results in increased expression of F12 mRNA CTD PMID:36318118 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G Fam131c family with sequence similarity 131, member C increases expression ISO Niclosamide results in increased expression of FAM131C mRNA CTD PMID:36318118 NCBI chr 5:153,674,459...153,690,791
Ensembl chr 5:153,671,772...153,690,800
JBrowse link
G Fam135b family with sequence similarity 135, member B increases expression ISO Niclosamide results in increased expression of FAM135B mRNA CTD PMID:36318118 NCBI chr 7:103,380,981...103,649,802
Ensembl chr 7:103,386,915...103,649,708
JBrowse link
G Fam13b family with sequence similarity 13, member B decreases expression ISO Niclosamide results in decreased expression of FAM13B mRNA CTD PMID:36318118 NCBI chr18:26,040,285...26,107,112
Ensembl chr18:26,040,285...26,106,587
JBrowse link
G Fam221a family with sequence similarity 221, member A increases expression ISO Niclosamide results in increased expression of FAM221A mRNA CTD PMID:36318118 NCBI chr 4:78,337,296...78,358,918
Ensembl chr 4:78,337,296...78,358,909
JBrowse link
G Fam43a family with sequence similarity 43, member A increases expression ISO Niclosamide results in increased expression of FAM43A mRNA CTD PMID:36318118 NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401
JBrowse link
G Fam43b family with sequence similarity 43, member B increases expression ISO Niclosamide results in increased expression of FAM43B mRNA CTD PMID:36318118 NCBI chr 5:150,610,656...150,613,054
Ensembl chr 5:150,611,609...150,612,601
JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO Niclosamide results in decreased expression of FAM83D mRNA CTD PMID:28284560 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
JBrowse link
G Fancb FA complementation group B decreases expression ISO Niclosamide results in decreased expression of FANCB mRNA CTD PMID:36318118 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO
EXP
Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]
CTD PMID:28318631 PMID:33632240 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fastkd3 FAST kinase domains 3 decreases expression ISO Niclosamide results in decreased expression of FASTKD3 mRNA CTD PMID:36318118 NCBI chr 1:34,858,342...34,866,988
Ensembl chr 1:34,858,219...34,866,973
JBrowse link
G Fbxo2 F-box protein 2 increases expression ISO Niclosamide results in increased expression of FBXO2 mRNA CTD PMID:36318118 NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355
JBrowse link
G Fbxo48 F-box protein 48 increases expression ISO Niclosamide results in increased expression of FBXO48 mRNA CTD PMID:36318118 NCBI chr14:91,380,857...91,382,314
Ensembl chr14:91,380,857...91,382,314
JBrowse link
G Fcho1 FCH and mu domain containing endocytic adaptor 1 increases expression ISO Niclosamide results in increased expression of FCHO1 mRNA CTD PMID:36318118 NCBI chr16:18,413,452...18,430,795
Ensembl chr16:18,413,363...18,435,104
JBrowse link
G Fcrlb Fc receptor-like B increases expression ISO Niclosamide results in increased expression of FCRLB mRNA CTD PMID:36318118 NCBI chr13:83,148,685...83,157,157
Ensembl chr13:83,149,751...83,155,957
JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO Niclosamide results in decreased expression of FEN1 mRNA CTD PMID:36318118 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Fgd1 FYVE, RhoGEF and PH domain containing 1 increases expression ISO Niclosamide results in increased expression of FGD1 mRNA CTD PMID:36318118 NCBI chr  X:20,023,746...20,066,734
Ensembl chr  X:20,023,746...20,066,566
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein CTD PMID:25174399 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf19 fibroblast growth factor 19 increases expression ISO Niclosamide results in increased expression of FGF19 mRNA CTD PMID:36318118 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 increases expression ISO Niclosamide results in increased expression of FGFR4 mRNA CTD PMID:36318118 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Fignl1 fidgetin-like 1 decreases expression ISO Niclosamide results in decreased expression of FIGNL1 mRNA CTD PMID:36318118 NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions
decreases expression
ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
Niclosamide results in decreased expression of FKBP5 mRNA
CTD PMID:28500234 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 decreases expression ISO Niclosamide results in decreased expression of FLRT3 mRNA CTD PMID:36318118 NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841
JBrowse link
G Fmn1 formin 1 increases expression ISO Niclosamide results in increased expression of FMN1 mRNA CTD PMID:36318118 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]
CTD PMID:28318631 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fndc10 fibronectin type III domain containing 10 increases expression ISO Niclosamide results in increased expression of FNDC10 mRNA CTD PMID:36318118 NCBI chr 5:166,299,587...166,311,477
Ensembl chr 5:166,300,122...166,310,326
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Niclosamide results in increased expression of FNDC4 mRNA CTD PMID:36318118 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]
CTD PMID:26792726 PMID:28824321 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Niclosamide results in increased expression of FOSB mRNA CTD PMID:28284560 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Niclosamide results in increased expression of FOSL1 mRNA CTD PMID:22576131 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxl1 forkhead box L1 increases expression ISO Niclosamide results in increased expression of FOXL1 mRNA CTD PMID:36318118 NCBI chr19:49,197,269...49,200,682
Ensembl chr19:49,197,400...49,198,425
JBrowse link
G Foxm1 forkhead box M1 multiple interactions
decreases expression
ISO Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein] CTD PMID:27492973 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Foxo4 forkhead box O4 increases expression ISO Niclosamide results in increased expression of FOXO4 mRNA CTD PMID:36318118 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115
JBrowse link