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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-aminoimidazole-4-carboxamide
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Accession:CHEBI:2030 term browser browse the term
Definition:An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.
Synonyms:related_synonym: 4-amino-1H-imidazole-5-carboxamide;   4-amino-5-carbamoylimidazole;   4-amino-5-imidazolecarboxamide;   5(4)-amino-4(5)-imidazolecarboxamide;   5-amino-4-imidazolecarboxyamide;   Formula=C4H6N4O;   InChI=1S/C4H6N4O/c5-3-2(4(6)9)7-1-8-3/h1H,5H2,(H2,6,9)(H,7,8);   InChIKey=DVNYTAVYBRSTGK-UHFFFAOYSA-N;   SMILES=NC(=O)c1nc[nH]c1N
 alt_id: CHEBI:20544
 xref: Drug_Central:1994;   HMDB:HMDB0003192;   KEGG:C04051
 xref_mesh: MESH:D000620
 xref: MetaCyc:CPD-3762;   PDBeChem:5AC;   PMID:12997251;   PMID:24402866;   Reaxys:3938



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5-aminoimidazole-4-carboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions
increases expression
EXP Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of ARG1 protein]
Aminoimidazole Carboxamide analog results in increased expression of ARG1 protein
CTD PMID:19853624 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
EXP Aminoimidazole Carboxamide analog results in increased expression of IL10 protein
Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; dorsomorphin inhibits the reaction [Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]
CTD PMID:19853624 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; dorsomorphin inhibits the reaction [Aminoimidazole Carboxamide promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] CTD PMID:19853624 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:19853624 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:19853624 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Aminoimidazole Carboxamide analog co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A protein; Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]; dorsomorphin inhibits the reaction [Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]] CTD PMID:19853624 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Aminoimidazole Carboxamide analog co-treated with Lipopolysaccharides] results in increased expression of RELA protein; Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein] CTD PMID:19853624 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Lipopolysaccharides co-treated with Aminoimidazole Carboxamide analog] results in increased expression of TGFB1 protein CTD PMID:19853624 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP [dorsomorphin co-treated with Aminoimidazole Carboxamide analog] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Aminoimidazole Carboxamide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Aminoimidazole Carboxamide analog results in increased expression of TNF protein
CTD PMID:19853624 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    chemical entity 19738
      atom 19738
        nonmetal atom 19678
          nitrogen atom 18877
            nitrogen molecular entity 18877
              organonitrogen compound 18712
                carboxamide 17497
                  monocarboxylic acid amide 15562
                    5-aminoimidazole-4-carboxamide 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        carboacyl group 17656
                                          univalent carboacyl group 17656
                                            carbamoyl group 17497
                                              carboxamide 17497
                                                monocarboxylic acid amide 15562
                                                  5-aminoimidazole-4-carboxamide 9
paths to the root