Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:AP20187
go back to main search page
Accession:CHEBI:136847 term browser browse the term
Definition:A tertiary amino compound that is 2-(aminomethyl)-N,N-dimethylpropane-1,3-diamine in which the primary ammino groups have each been acylated by condensation with the carboxy group of 2-{3-[(1R)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy}acetic acid, the hydroxy groups of which have been esterified by condensation with the carboxy group of L-pipecolic acid, the nitrogen of which has been acylated by condensation with (2S)-2-(3,4,5-trimethoxyphenyl)butyric acid. It is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain.
Synonyms:exact_synonym: (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-({3-[2-(3-{(1R)-3-(3,4-dimethoxyphenyl)-1-[({(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidin-2-yl}carbonyl)oxy]propyl}phenoxy)acetamido]-2-[(dimethylamino)methyl]propyl}amino)-2-oxoethoxy]phenyl}propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
 related_synonym: AP 20187;   B/B Homodimerizer;   Formula=C82H107N5O20;   InChI=1S/C82H107N5O20/c1-15-61(57-43-71(98-9)77(102-13)72(44-57)99-10)79(90)86-37-19-17-27-63(86)81(92)106-65(33-29-52-31-35-67(94-5)69(39-52)96-7)55-23-21-25-59(41-55)104-50-75(88)83-47-54(49-85(3)4)48-84-76(89)51-105-60-26-22-24-56(42-60)66(34-30-53-32-36-68(95-6)70(40-53)97-8)107-82(93)64-28-18-20-38-87(64)80(91)62(16-2)58-45-73(100-11)78(103-14)74(46-58)101-12/h21-26,31-32,35-36,39-46,54,61-66H,15-20,27-30,33-34,37-38,47-51H2,1-14H3,(H,83,88)(H,84,89)/t61-,62-,63-,64-,65+,66+/m0/s1;   InChIKey=NSBGUMKAXUXKGI-BPNHAYRBSA-N;   SMILES=C(C(CNC(COC=1C=C(C=CC1)[C@@H](CCC2=CC(=C(C=C2)OC)OC)OC([C@H]3N(C([C@@H](CC)C4=CC(=C(C(=C4)OC)OC)OC)=O)CCCC3)=O)=O)CN(C)C)NC(COC=5C=C(C=CC5)[C@@H](CCC6=CC(=C(C=C6)OC)OC)OC([C@H]7N(C([C@@H](CC)C8=CC(=C(C(=C8)OC)OC)OC)=O)CCCC7)=O)=O
 xref: CAS:195514-80-8
 xref_mesh: MESH:C463061
 xref: PMID:17328681;   PMID:17962474;   PMID:24421317;   PMID:25928330;   PMID:27604214;   PMID:28173622;   PMID:28191782;   Patent:US6150527;   Patent:WO2012103279;   Reaxys:22811386;   Wikipedia:AP20187


show annotations for term's descendants           Sort by:
 
AP20187 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [AP20187 results in increased activity of INSR protein mutant form] which results in decreased expression of BCL2L1 mRNA CTD PMID:29330302 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Egr3 early growth response 3 multiple interactions ISO [AP20187 results in increased activity of IGF1R protein mutant form] which results in increased expression of EGR3 mRNA CTD PMID:29330302 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases activity ISO AP20187 results in increased activity of FGFR1 protein mutant form CTD PMID:12654294 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [AP20187 results in increased activity of INSR protein mutant form] which results in decreased expression of HK2 mRNA CTD PMID:29330302 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO [AP20187 results in increased activity of IGF1R protein mutant form] which results in increased expression of EGR3 mRNA CTD PMID:29330302 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Insr insulin receptor multiple interactions ISO [AP20187 results in increased activity of INSR protein mutant form] which results in decreased expression of BCL2L1 mRNA; [AP20187 results in increased activity of INSR protein mutant form] which results in decreased expression of HK2 mRNA; [AP20187 results in increased activity of INSR protein mutant form] which results in decreased expression of JUN mRNA CTD PMID:29330302 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [AP20187 results in increased activity of INSR protein mutant form] which results in decreased expression of JUN mRNA CTD PMID:29330302 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO AP20187 results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      chemical role 19255
        ligand 5809
          AP20187 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            inorganic hydride 17459
                              pnictogen hydride 17434
                                nitrogen hydride 17281
                                  azane 17016
                                    ammonia 17015
                                      organic amino compound 17014
                                        tertiary amino compound 8651
                                          AP20187 8
paths to the root