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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pramipexole
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Accession:CHEBI:8356 term browser browse the term
Definition:A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.
Synonyms:exact_synonym: (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
 related_synonym: 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-;   Formula=C10H17N3S;   InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1;   InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N;   SMILES=CCCN[C@H]1CCc2nc(N)sc2C1;   pramipexol;   pramipexolum
 xref: Beilstein:6479326;   CAS:104632-26-0;   DrugBank:DB00413;   Drug_Central:2233;   KEGG:D00559;   KEGG:D05575;   LINCS:LSM-5243
 xref_mesh: MESH:C061333
 xref: Patent:EP186087;   Patent:US4886812;   Wikipedia:Pramipexole
 cyclic_relationship: is_conjugate_base_of CHEBI:63218


show annotations for term's descendants           Sort by:
pramipexole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in increased activity of ACHE protein] CTD PMID:35868426 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions EXP Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of ATP5F1A protein] CTD PMID:35868426 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] CTD PMID:16362428 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP
ISO		 pramipexole binds to and results in increased activity of DRD2 protein CTD PMID:10728880 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO pramipexole binds to and results in increased activity of DRD3 protein CTD PMID:10728880 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] CTD PMID:16362428 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP pramipexole inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] CTD PMID:16362428 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Pramipexole results in increased expression of PPARGC1A protein CTD PMID:35868426 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D increases expression EXP [Pramipexole cotreated with exercise] increases expression of Ptprd protein in the striatum RGD PMID:37633178 RGD:401976430 NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions EXP Pramipexole inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of SDHB protein] CTD PMID:35868426 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      chemical role 19460
        antioxidant 16146
          radical scavenger 6626
            pramipexole 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        polyamine 9025
                                          diamine 8960
                                            pramipexole 10
paths to the root