CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydroxyzine
Accession: CHEBI:5818
browse the term
Definition: A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Synonyms: exact_synonym: 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol
related_synonym: Formula=C21H27ClN2O2; Hychotine; Hydroxine; Hydroxizine; Hydroxizinum; Hydroxycine; Hydroxyzin; InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2; InChIKey=ZQDWXGKKHFNSQK-UHFFFAOYSA-N; SMILES=OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1; hidroxizina; hydroxyzinum
xref: Beilstein:321392; CAS:68-88-2; DrugBank:DB00557; Drug_Central:1400; HMDB:HMDB0014697; KEGG:C07045; KEGG:D08054; LINCS:LSM-5103
xref_mesh: MESH:D006919
xref: PMID:15233966; PMID:19057127; PMID:19348661; Patent:US2899436; Reaxys:321392; VSDB:2977; Wikipedia:Hydroxyzine
G
Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
Hydroxyzine results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
G
Ace2
angiotensin converting enzyme 2
increases activity decreases expression
ISO
Hydroxyzine results in increased activity of ACE2 protein Hydroxyzine results in decreased expression of ACE2 mRNA
CTD
PMID:21859683 PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
G
Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Hydroxyzine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Hexb
hexosaminidase subunit beta
affects secretion
EXP
Hydroxyzine affects the secretion of HEXB protein
CTD
PMID:7655991
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
G
Hrh1
histamine receptor H 1
multiple interactions
ISO
Hydroxyzine binds to and results in decreased activity of HRH1 protein
CTD
PMID:2864258 PMID:19057127
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
G
Il1b
interleukin 1 beta
decreases expression
ISO
Hydroxyzine results in decreased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il24
interleukin 24
increases expression
ISO
Hydroxyzine results in increased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
G
Il4
interleukin 4
decreases expression
ISO
Hydroxyzine results in decreased expression of IL4 protein
CTD
PMID:19672097
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Hydroxyzine results in decreased activity of KCNH2 protein
CTD
PMID:19057127
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Hydroxyzine results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Hydroxyzine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Hydroxyzine results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all