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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:epinastine
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Accession:CHEBI:51032 term browser browse the term
Definition:A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Synonyms:exact_synonym: 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
 related_synonym: 3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine;   Formula=C16H15N3;   InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18);   InChIKey=WHWZLSFABNNENI-UHFFFAOYSA-N;   SMILES=NC1=NCC2N1c1ccccc1Cc1ccccc21;   epinastina;   epinastinum
 xref: Beilstein:3593307;   CAS:80012-43-7;   DrugBank:DB00751;   Drug_Central:1027;   KEGG:D07900
 xref_mesh: MESH:C053090
 xref: Patent:GB2071095;   Patent:US4313931;   Reaxys:3593307;   Wikipedia:Epinastine


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epinastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A affects transport EXP ABCB1A affects the transport of epinastine CTD PMID:15100174 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects transport EXP ABCB1B affects the transport of epinastine CTD PMID:15100174 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Hrh1 histamine receptor H1 multiple interactions ISO [epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] CTD PMID:12832840 PMID:19075512 NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257 		JBrowse link
G Ifng interferon gamma multiple interactions ISO epinastine inhibits the reaction [IL4 results in decreased expression of IFNG] CTD PMID:16534218 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il13 interleukin 13 decreases expression ISO epinastine results in decreased expression of IL13 mRNA; epinastine results in decreased expression of IL13 protein CTD PMID:16534218 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]
epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]		 CTD PMID:16534218 PMID:19075512 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 decreases expression ISO epinastine results in decreased expression of IL5 mRNA; epinastine results in decreased expression of IL5 protein CTD PMID:16534218 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il6 interleukin 6 decreases expression ISO epinastine results in decreased expression of IL6 mRNA; epinastine results in decreased expression of IL6 protein CTD PMID:16534218 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO epinastine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Ngf nerve growth factor decreases expression EXP epinastine results in decreased expression of NGF protein CTD PMID:19937255 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO epinastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      biological role 22166
        pharmacological role 19778
          antagonist 17515
            histamine antagonist 4871
              epinastine 11
                R-epinastine 0
                S-epinastine 0
                epinastine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      carbon group element atom 21909
                        carbon atom 21835
                          organic molecular entity 21835
                            organic molecule 21652
                              organic cyclic compound 21261
                                organic heterocyclic compound 20329
                                  organic heteropolycyclic compound 19619
                                    organic heterobicyclic compound 18182
                                      benzazepine 534
                                        epinastine 11
                                          R-epinastine 0
                                          S-epinastine 0
                                          epinastine hydrochloride 0
paths to the root