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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:etomidate
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Accession:CHEBI:4910 term browser browse the term
Definition:The ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity.
Synonyms:exact_synonym: ethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate
 related_synonym: (+)-ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate;   (R)-(+)-1-(alpha-methylbenzyl)imidazole-5-carboxylic acid ethyl ester;   (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester;   3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester;   Formula=C14H16N2O2;   InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1;   InChIKey=NPUKDXXFDDZOKR-LLVKDONJSA-N;   R-(+)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate;   SMILES=CCOC(=O)c1cncn1[C@H](C)c1ccccc1;   etomidato;   etomidatum
 alt_id: CHEBI:129090
 xref: CAS:33125-97-2;   DrugBank:DB00292;   Drug_Central:1109;   KEGG:C07522;   KEGG:D00548;   LINCS:LSM-37126
 xref_mesh: MESH:D005045
 xref: PMID:12646036;   PMID:18348518;   Patent:DE2609573;   Patent:US3991072


show annotations for term's descendants           Sort by:
etomidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]; Etomidate promotes the reaction [ALB protein modified form results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25421967 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Etomidate CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Etomidate promotes the reaction [ALB protein modified form results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25421967 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP		 Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:10049148 PMID:12939268 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 multiple interactions
affects response to substance		 ISO Etomidate binds to and results in increased activity of GABRA5 protein
GABRA5 protein affects the susceptibility to Etomidate		 CTD PMID:16597725 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]] CTD PMID:10049148 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions		 ISO
EXP		 GABRB2 protein affects the susceptibility to Etomidate
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:12490572 PMID:12939268 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases response to substance
multiple interactions		 ISO GABRB3 protein results in increased susceptibility to Etomidate
Etomidate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]		 CTD PMID:9523823 PMID:21111751 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions ISO Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]] CTD PMID:10049148 NCBI chr  X:150,060,035...150,078,773
Ensembl chr  X:150,060,040...150,078,693 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP		 Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:10049148 PMID:12939268 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Stx1a syntaxin 1A affects localization EXP Etomidate affects the localization of STX1A protein CTD PMID:29320738 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          disinfectant 13880
            ethanol 8808
              ethyl ester 4136
                etomidate 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  heteroarene 17135
                                    monocyclic heteroarene 14869
                                      azole 14371
                                        diazole 10481
                                          imidazoles 9884
                                            imidazolyl carboxylic acid 11
                                              1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid 11
                                                etomidate 11
paths to the root