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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imidazolyl carboxylic acid
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Accession:CHEBI:38307 term browser browse the term
Definition:Any member of the class of imidazoles in which the imidazole ring is substituted by one (or more) carboxy group(s).
Synonyms:related_synonym: imidazolyl carboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:38466


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etomidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]; Etomidate promotes the reaction [ALB protein modified form results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25421967 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Etomidate CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418 JBrowse link
G Casp3 caspase 3 multiple interactions ISO Etomidate promotes the reaction [ALB protein modified form results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25421967 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases activity
multiple interactions
ISO Etomidate results in decreased activity of CYP11B1 protein
Etomidate inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]
CTD PMID:18651133 NCBI chr 7:106,808,559...106,814,048 JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:10049148 PMID:12939268 NCBI chr10:26,595,151...26,650,611 JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 multiple interactions
affects response to substance
ISO Etomidate binds to and results in increased activity of GABRA5 protein
GABRA5 protein affects the susceptibility to Etomidate
CTD PMID:16597725 NCBI chr 1:108,268,728...108,381,670 JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]] CTD PMID:10049148 NCBI chr14:36,068,725...36,548,946 JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions
ISO
EXP
GABRB2 protein affects the susceptibility to Etomidate
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:12490572 PMID:12939268 NCBI chr10:26,936,592...27,156,141 JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases response to substance
multiple interactions
ISO GABRB3 protein results in increased susceptibility to Etomidate
Etomidate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]
CTD PMID:9523823 PMID:21111751 NCBI chr 1:108,467,047...108,702,522 JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions ISO Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]] CTD PMID:10049148 NCBI chr  X:150,060,035...150,078,773 JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:10049148 PMID:12939268 NCBI chr10:26,376,805...26,463,680 JBrowse link
G Stx1a syntaxin 1A affects localization EXP Etomidate affects the localization of STX1A protein CTD PMID:29320738 NCBI chr12:21,641,971...21,670,022 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      chemical role 19254
        donor 18500
          Bronsted acid 18368
            oxoacid 18328
              carbon oxoacid 18201
                carboxylic acid 18195
                  aromatic carboxylic acid 11288
                    imidazolyl carboxylic acid 12
                      1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid + 12
                      1-methyl-5-imidazoleacetic acid 0
                      1-methyl-imidazole-2-carboxylic acid 0
                      1-methyl-imidazole-4-carboxylic acid 0
                      1-methylimidazol-4-ylacetic acid 0
                      3-(1H-imidazol-1-yl)propanoic acid 0
                      3-(imidazol-1-yl)lactic acid 0
                      3-(imidazol-1-yl)pyruvic acid 0
                      5-methyl-imidazole-2-carboxylic acid 0
                      5-methyl-imidazole-4-carboxylic acid 0
                      imidazol-1-ylacetic acid 0
                      imidazole-4-carboxylic acid + 0
                      zolasartan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  heteroarene 16514
                                    monocyclic heteroarene 13389
                                      azole 12569
                                        diazole 8248
                                          imidazoles 7680
                                            imidazolyl carboxylic acid 12
                                              1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid + 12
                                              1-methyl-5-imidazoleacetic acid 0
                                              1-methyl-imidazole-2-carboxylic acid 0
                                              1-methyl-imidazole-4-carboxylic acid 0
                                              1-methylimidazol-4-ylacetic acid 0
                                              3-(1H-imidazol-1-yl)propanoic acid 0
                                              3-(imidazol-1-yl)lactic acid 0
                                              3-(imidazol-1-yl)pyruvic acid 0
                                              5-methyl-imidazole-2-carboxylic acid 0
                                              5-methyl-imidazole-4-carboxylic acid 0
                                              imidazol-1-ylacetic acid 0
                                              imidazole-4-carboxylic acid + 0
                                              zolasartan 0
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